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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Novel, anionic, ao- tiviral septapeptidcs from mosquito cells also protect monkey cells against dengue virus显示文摘 | Lausulttfipong C Kanthong N Fh'gel T W | 2013 | Antiviral Res2013，98，3： | 1 |
| 3 | 显示文摘 | NILSSON C VIBERG P SP(E)GEL P JOERNTEN-KARLSSON M PETERSSON P NILSSON S | 2006 | Anal Chem2006，78，17： | 1 |
| 4 | Properties of collagen from skins cod(Gadus morhua) and hake(Merluccius Merluccius) and their modification by the coenhancers magnesium sulphate, glycerol and transglutaminase 显示文摘 | Fernandez-Diaz M D Montero P Gomez-Guillen M C Gel | 2001 | Food Chemistry2001，，74： | 1 |
| 5 | Administered mesenchymal stem cells enhance recovery from ischemia/reperfusion - induced acute renal faiIure in rats 显示文摘 | Lange C T~gel F Ittrich H | 2005 | Kidney Int2005，68，4： | 1 |
| 6 | influence of composition of gels on their color and study of their stability during storage 显示文摘 | Calvo C Salvador A Use of natural colorants in food gels | 2000 | Food Hydrocolloids2000，14，5： | 1 |
| 7 | Oncological quality and preliminary long-term results in laparoscopic colorectal surgery显示文摘 | Seheidbach H Schneider C Hügel O | 2003 | Surg Endosc2003，17，6： | 1 |
| 8 | Preparati of novel hyperbranche electrolytes显示文摘 | Wu C Wu F characteristics based gel polymer Chilean Chemical Bai Y | 2009 | Journal on and d PEU- of the Society2009，54，3： | 1 |
| 9 | Protective effects of carvedilol in murine model with the coxsackievirus B3-induced viral myocarditis 显示文摘 | LI Y C GEL S REN J H | 2008 | J Cardiovasc Pharmacol2008，51，： | 1 |
| 10 | Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway显示文摘 | Chen Y Gels C Sommer C | 2008 | J Neurosci2008，28，22： | 1 |
| 11 | Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3- only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway 显示文摘 | Reimertz C K~gel D Rami A | 2003 | J Cell Biol2003，162，4： | 1 |
| 12 | Inhibition of propionate degradation by acetate in methanogenie fluldized bed reactors 显示文摘 | LGM Gorris JMA van Deursen C van der Drift G D Vo- gels | 1989 | Bioteehnolgy Let- ters1989，11，1： | 1 |
| 13 | Oncological quality and preliminary long-term results in laparoscopic colorectal surgery显示文摘 | Scheidbach H Schneider C Hügel O | 2003 | Surg Endosc2003，17，6： | 1 |
| 14 | Electrically tunable quantum anomalous Hall effect in graphene decorated by 5d transition-metal adatoms 显示文摘 | Zhang H Lazo C Blügel S Heinze S Mokrousov Y | 2012 | Phys Rev Lett2012，108，05： | 1 |
| 15 | Optical limiting of short laser pulses显示文摘 | Liu J C Wang C K Gel' mukhanov F | 2007 | Phys Rev A2007，76，05： | 1 |
| 16 | Oncological quality and preliminary long-term results in laparoscopic colorectal surgery显示文摘 | Scheidbach H Schneider C Hügel O | 2003 | Surg Endosc2003，17，6： | 1 |
| 17 | Optimizationby simulated annealing显示文摘 | KIRKPATRIC S GEL ATT C D VECCHI M P | 1983 | Science1983，220，： | 1 |
| 18 | Electron field emission from diamond and other carbon materials after H2, 02, and Cs Ireatment 显示文摘 | GElS M W TWICHELL J C | 1995 | Appl Phys Lett1995，67，9： | 1 |
| 19 | At what level (and in whom) we trust trust across multiple organizational levels显示文摘 | Fulmer C A and Gel{and M J | 2012 | Journal of Man- agement2012，38，4： | 1 |
| 20 | Short Communication:Stability of a Recombinant Plasmid Cartying a-Amylase Gene in Bacillus subtilis显示文摘 | GUERAKAN G C BAYONDORLOA OE GEL Z B | 1997 | World Journal of Microbiology and Biotechnology1997，14，： | 1 |
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