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| 1 | Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses显示文摘一个鸟起源的 H7N9 流行性感冒病毒的流行病最近出现在中国,感染 45 死于的 134 个病人。这是怀有 N9 serotype neuraminidase (NA ) 的一个流行性感冒病毒被知道了感染人的第一次。H7N9 病毒是分叉的并且至少二不同 NA 和红血球凝聚素() 分别地,被发现了从临床孤立。这些病毒的原型是 A/Anhui/1/2013 和 A/Shanghai/1/2013。当 A/Shanghai/1/2013 NA 有能授与 NA 禁止者 oseltamivir 抵抗的 R294K 替换,从这二个病毒的 NA 是不同的。Oseltamivir 迄今为止由于它的力量和高 bioavailability 是最通常使用的反流行性感冒药。在这研究,我们证明 R294K 替换用基于蛋白质、基于病毒的试金与极端 oseltamivir 抵抗(超过 100 000 褶层) 导致 multidrug 抵抗。为禁止者抵抗决定分子的基础,我们从 A/Anhui/1/2013 N9 (包含 R294 ) 和 A/Shanghai/1/2013 N9 (包含 K294 ) 解决了 NA 的高分辨率的水晶结构。在为 oseltamivir 绑定的相反的 E276 符合构造的 R294K 替换结果,并且因而禁止者羧化物相互作用的损失,它损害所有古典 NA ligands/inhibitors 的绑定。而且,我们与更低的病毒的健康一起在减少的 NA 催化效率发现那 R294K 替换结果。这帮助解释 K294 为什么主要在 oseltamivir 处理并且不在主导的人感染的病毒的选择压力下面在 H7N9 感染的临床的情况中被发现了。这暗示 oseltamivir 能高效地仍然在 H7N9 感染的处理被使用。 | YanWu #x0002A YuhaiBi #x0002A Christopher JVavricka #x0002A XiaomanSun YanfangZhang FengGao MinZhao HaixiaXiao ChengfengQin JianhuaHe WenjunLiu JinghuaYan JianxunQi George FGao | 2013 | Cell Research2013，，12： | 15 |
| 2 | Regula- tory T cells and IL-10 levels are reduced in patients with vulnerable coronary plaques 显示文摘 | George J Sehwartzenberg S Medvedovsky 1) | 2012 | Atheroselerosis2012，222，2： | 1 |
| 3 | Innovation for inclusive growth: Towards a theoretical framework and a research agenda显示文摘 | George G McGahan A M Prabhu 1 | 2012 | Journal of management studies2012，49，4： | 1 |
| 4 | Type 1 diabetes: recent developments 显示文摘 | DEVASENAN DEVENDRA EDWIN LIU GEORGE S EISENBARTH Type 1 | 2004 | BMJ2004，328，： | 1 |
| 5 | Novel low loss, low permittivity glass-ceramic composites for LTCC applications C 显示文摘 | George S Sebastian M :1' Raman S | 2011 | International journal of applied ceramic technology2011，，1： | 1 |
| 6 | Hepatotoxicity of commonly used drugs: nonsteroidal anti-inflammatory drugs, antihyperte nsives, antidiabetic agents, anticonvulsants, lipid-lowering agents, psychotropic drugs 显示文摘 | Chitturi S George 1 | 2002 | Seminars in liver disease2002，22，2： | 1 |
| 7 | Utility of single luteinizing hormone determination 3 h after depot leuprolide in monitoring therapy of gonadotropin-dependent precocious puberty 显示文摘 | Acharya SV Gopal RA George 1 | 2009 | Pituitary2009，12，4： | 1 |
| 8 | A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients 显示文摘 | Bagshaw SM George C Dinu 1 | 2008 | Nephrol Dial Transplant2008，23，4： | 1 |
| 9 | Adsorption equilibrium of binary proteins to Q Sepharose FF显示文摘Simultaneous and sequential adsorptions of bovine serum albumin(BSA) and bovine hemoglobin(bHb) was investigated on anion ion-exchange media Q Sepharose FF in batch adsorption experiments to elucidate the mechanism of multi-component protein adsorption.BSA is always preferential adsorbed with bHb inhibited in binary adsorption.Influence on binary adsorption of factors such as pH,salt concentration,initial concentration ratios of proteins and the adsorption sequence are determined.Three models have been tested and compared to describe the competitive binary adsorption of BSA and bHb in all conditions studied.Among the extended Langmuir model gives the best predict of adsorption of the stronger adsorbed protein when its adsorption is not very strong in simultaneous adsorption,the Statistical thermodynamic(ST) model gives the best description of weaker adsorbed protein in simultaneous adsorption,the Steric mass-action(SMA) model is most appropriate multi-component model considering all different conditions for both proteins. | LIANG Juan~(1,2),FIEG Georg~2,LUO Xing~2,SHI Qinghong~1,SUN Yan~1 (1 Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of Ministry of Education, School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China 2 Institute of Process and Plant Engineering,Hamburg University of Technology,Schwarzenbergstrasse 95,21073 Hamburg,Germany) | 2011 | 化工进展2011，30，S2： | 0 |
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