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| 1 | Spatiotemporal visualization for the global COVID-19 surveillance by balloon chart显示文摘Background:Considering the widespread of coronavirus disease 2019(COVID-19)pandemic in the world,it is important to understand the spatiotemporal development of the pandemic.In this study,we aimed to visualize time-associated alterations of COVID-19 in the context of continents and countries. | Ming-Fan Pang Zuo-Ru Liang Zhi-Da Cheng Xin-Ping Yang Jie-Wen Wu Ke Lyu Jing-Jing Xi Zhong-Jie Li Guo-Qing Shi Yan-Ping Zhang George FGao Xiao-Peng Qi Xiao-Ping Dong | 2021 | Infectious Diseases of Poverty2021，10，2： | 6 |
| 2 | Virtual reality forstroke rehabilitation 显示文摘 | Laver KE George S Thomas S et M | 2011 | Cochrane Database Syst Rev2011，，00： | 1 |
| 3 | Photodynamic Therapy for Distaland Lateral Subungual Toenail Onychomycosis Caused by Trichnphy-ton rubrum: Preliminary Results of a Single-centre Open Trial 显示文摘 | Eleni S Thalia KE George C | 2009 | AmAcad Dermatol2009，90，： | 1 |
| 4 | The Notch pathway in colorectal cancer 显示文摘 | Vinson KE George DC Fender AW | 2016 | Int J Cancer2016，138，8： | 1 |
| 5 | East Asian monsoon evolution and reconciliation of climate records from Japan and Greenland during the last deglaciation显示文摘 | Chuan-Chou Shen Akihiro Kano Masako Hori Ke Lin Tzu-Chien Chiu George S. Burr | 2010 | Quaternary Science Reviews2010，，23： | 1 |
| 6 | Genioglossus reflex inhibition to upper-airway negative-pressure stimuli during wakefulness and sleep in healthy males显示文摘 | Eckert DJ McEvoy RD George KE | 2007 | J Physiol2007，581，3： | 1 |
| 7 | Intra-host Ebola viral adaption during human infection显示文摘The onsite next generation sequencing(NGS)of Ebola virus(EBOV)genomes during the 2013–2016 Ebola epidemic in Western Africa provides an opportunity to trace the origin,transmission,and evolution of this virus.Herein,we have diagnosed a cohort of EBOV patients in Sierra Leone in 2015,during the late phase of the outbreak.The surviving EBOV patients had a recovery process characterized by decreasing viremia,fever,and biochemical parameters.EBOV genomes sequenced through the longitudinal blood samples of these patients showed dynamic intra-host substitutions of the virus during acute infection,including the previously described short stretches of 13 serial TNC mutations.Remarkably,within individual patients,samples collected during the early phase of infection possessed Ts at these nucleotide sites,whereas they were replaced by Cs in samples collected in the later phase,suggesting that these short stretches of TNC mutations could emerge independently.In addition,up to a total of 35 nucleotide sites spanning the EBOV genome were mutated coincidently.Our study showed the dynamic intra-host adaptation of EBOV during patient recovery and gave more insight into the complex EBOV-host interactions. | William JLiu Weifeng Shi Wuyang Zhu Cong Jin Shumei Zou Ji Wang Yuehua Ke Xiaofeng Li Mi Liu Tao Hu Hang Fan Yigang Tong Xiang Zhao Wenbin Chen Yuhui Zhao Di Liu Gary Wong Chengchao Chen Chunyu Geng Weiwei Xie Hui Jiang Idrissa Laybor Kamara Abdul Kamara Matt Lebby Brima Kargbo Xiangguo Qiu Yu Wang Xiaofeng Liang Mifang Liang Xiaoping Dong Guizhen Wu George F.Gao Yuelong Shu | 2019 | Biosafety and Health2019，1，1： | 1 |
| 8 | Effects of hypoxia on genioglossus and scalene reflex responses to brief pulses of negative upper-airway pressure during wakefulness and sleep in healthy men显示文摘 | Eckert DJ McEvoy RD George KE | 2008 | J Appl Physiol2008，104，5： | 1 |
| 9 | Primary Endpoint Results of a Phase II Study of Vascular Endothelial Growth Factor Trap-Eye in Wet Age-related Macular Degeneration显示文摘 | David M. Brown Jeffrey S. Heier Thomas Ciulla Matthew Benz Prema Abraham George Yancopoulos Neil Stahl Avner Ingerman Robert Vitti Alyson J. Berliner Ke Yang Quan Dong Nguyen | 2011 | Ophthalmology2011，，6： | 1 |
| 10 | Virtual reality for stroke rehabilitation显示文摘 | Laver KE George S Thomas S | 2011 | Cochrane Database Syst Rev2011，7，9： | 1 |
| 11 | Sex‐based differences in bleeding and long term adverse events after percutaneous coronary intervention for acute myocardial infarction: Three year results from the HORIZONS‐AMI trial显示文摘 | Jennifer Yu Roxana Mehran Liliana Grinfeld Ke Xu Eugenia Nikolsky Bruce R. Brodie Bernhard Witzenbichler Ran Kornowski George D. Dangas Alexandra J. Lansky Gregg W. Stone | 2015 | Cathet. Cardiovasc. Intervent2015，，： | 1 |
| 12 | Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells显示文摘AIM:To investigate the effect of aspirin on neuroendocrine tumor(NET)cell growth and signaling in vitro.METHODS:Human pancreatic BON1,bronchopulmonary NCI-H727 and midgut GOT1 neuroendocrine tumor cells were treated with different concentrations of aspirin(from 0.001 to 5 mmol/L),and the resulting effects on metabolic activity/cell proliferation were measured using cell proliferation assays and SYBR-DNAlabeling after 72,144 and 216 h of incubation.The effects of aspirin on the expression and phosphorylation of several critical proteins that are involved in the most common intracellular growth factor signaling pathways(especially Akt protein kinase B)and mammalian target of rapamycin(mTOR)were determined by Western blot analyses.Propidium iodide staining and flow cytometry were used to evaluate changes in cell cycle distribution and apoptosis.Statistical analysis was performed using a 2-tailed Student’s t-test to evaluate the proliferation assays and cell cycle analyses.The results are expressed as the mean±SD of 3 or 4 independently performed experiments.Statistical significance was set at P<0.05.RESULTS:Treatment with aspirin suppressed the viability/proliferation of BON1,NCI-H727 and GOT1 cells in a time-and dose-dependent manner.Significant effects were observed at starting doses of 0.5-1 mmol/L and peaked at 5 mmol/L.For instance,after treatment with 1 mmol/L aspirin for 144 h,the viability of pancreatic BON1 cells decreased to 66%±13%(P<0.05),the viability of bronchopulmonary NCI-H727 cells decreased to 53%±8%(P<0.01)and the viability of midgut GOT1 cells decreased to 89%±6%(P<0.01).These effects were associated with a decreased entry into the S phase,the induction of the cyclin-dependent kinase inhibitor p21 and reduced expression of cyclindependent kinase 4 and cyclin D3.Aspirin suppressed mTOR downstream signaling,evidenced by the reduced phosphorylation of the mTOR substrates 4E binding protein 1,serine/threonine kinase P70S6K and S6 ribosomal protein and inhibited glycogen synthase kinase3 activity.We observed the(compensatory)activation of tuberous sclerosis 2,the serine/threonine specific protein kinase AKT and extracellular signal-regulated kinases.CONCLUSION:Aspirin demonstrates promising anticancer properties for NETs in vitro.Further preclinical and clinical studies are needed. | Matilde Spampatti George Vlotides Gerald Spttl Julian Maurer Burkhard Gke Christoph J Auernhammer | 2014 | World Journal of Gastroenterology2014，20，29： | 1 |
| 13 | Use of polymeric plasticizers in polyvinyl chloride to reduce conventional plasticizer migration for critical applications显示文摘 | Sunny MC Ramesh P George KE | 2004 | J Elastomers Plastics2004，36，1： | 1 |
| 14 | Dynamic response of pile groups with different configurations 显示文摘 | George Gazetas Ke Fan Amr Kaynia | 1993 | Soil Dynamic and Earthquake Engineering1993，12，： | 1 |
| 15 | Virtual reality for stroke rehabilitation 显示文摘 | Laver KE George S Thomas S | 2011 | Cochrane Database Syst Rev2011，7，9： | 1 |
| 16 | Hypothermia is associated with improved outcomes in a porcine model of hemorrhagic shock显示文摘 | George ME Mulier KE Beilman GJ | 2010 | J Trauma2010，68，3： | 1 |
| 17 | Hypothermia is associated with improved outcomes in a porcine model of hemorrhagic shock 显示文摘 | George ME Mulier KE Beihnan GJ | 2010 | J Trauma2010，68，3： | 1 |
| 18 | Predictors and Implications of Stent Thrombosis in Non–ST-Segment Elevation Acute Coronary Syndromes: The ACUITY Trial显示文摘 | Tullio Palmerini George Dangas Roxana Mehran Adriano Caixeta Philippe Généreux Martin P. Fahy Ke Xu Ecaterina Cristea Alexandra J. Lansky Gregg W. Stone | 2011 | Circulation: Cardiovascular Interventions2011，，6： | 1 |
| 19 | Hypothermia is associated with improved outcomes in a porcine model of hemorrhagic shock显示文摘 | George ME Mulier KE Beilman GJ | 2010 | J Trauma2010，68，3： | 1 |
| 20 | Standards for the diagnosis of chronic pancreatitis and for the evaluation of treatment显示文摘 | Paul Georg Lankisch ?ke Andrén-Sandberg | 1993 | International Journal of Pancreatology1993，，3： | 1 |
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