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| 1 | Albert management of diabetes mellitus in surgical patients 显示文摘 | Jack SD George M | 2002 | Diabetes Spectrum2002，15，： | 1 |
| 2 | Improved quality of life for romiplostim-treated patients with chronic immune thrombocytopenic purpura:results from two randomized,placebo-controlled trials显示文摘 | George JN Mathias SD Go RS | | 0，，03： | 1 |
| 3 | Downregulation of the human heme oxygenase gene by glucocorticoids and identification of 56b regulatory elements 显示文摘 | Yan L George SD Nader GA | 1996 | Bioche and biophys Res1996，218，： | 1 |
| 4 | Human immunodeficiency vires type2 infection in the United States显示文摘 | O' Brien TR JR George SD Holmberg | 1992 | JAMA1992，267，： | 1 |
| 5 | Human immunodeficiency virus type 2 infection in the United States显示文摘 | O'Brien TR George J R Holmberg SD et a1 | 1992 | J Am Med Assoc1992，267，： | 1 |
| 6 | Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo 显示文摘 | George JC Nancy SD Michele D | 2003 | Am J Physiol Regul Integr Comp Physiol2003，84，5： | 1 |
| 7 | Improved quality of life for romiplostim-treated patients with chronic immune thrombocytopenic purpura:results from two randomized,placebo-controlled trials显示文摘 | George JN Mathias SD Go RS | 2009 | Br J Haematol2009，144，： | 1 |
| 8 | Improved quality of life for romiplostim-treated patients with chronic immune thrombocytopenic purpura: results from two randomized, placebo-controlled trials 显示文摘 | GEORGE JN MATHIAS SD GO RS | 2009 | Br J Haematol2009，144，3： | 1 |
| 9 | Humaninmmunodeficiency virus type2 fection in the United States显示文摘 | 0Breien TR George JR Holmberg SD | 1992 | J Am Med Aed Assoc1992，267，： | 1 |
| 10 | Umbilical cord blood-derlved mesenchymal stem cells consist of a unique population of progenitors co-expressing mesenchymal stem cell and neuronal markers capable of instantaneous neuronal differentiation 显示文摘 | MUNDACKAL SD GEORGE ER THULASI SD | 2012 | Stem Cell Res Ther2012，3，6： | 1 |
| 11 | Neutrophil and e- osinophil participation in atopic and vernal keratoconjunctivi- tis显示文摘 | Trocme SD Leiferman KM George T | 2003 | Curr Eye Res2003，26，6： | 1 |
| 12 | A comparison of themorphology,gas space anatomy and potential for internal aeration in Phragmites aus- tralis under variable and static water regimes 显示文摘 | White SD George G | 2002 | Aquat Bot2002，73，2： | 1 |
| 13 | High flotillin-2 expres- sion is associated with lymph node metastasis and Breslow depth in melanoma显示文摘 | Doherty SD Prieto VG George S | 2006 | Melanoma Res2006，16，5： | 1 |
| 14 | Albert management of diabetes mellitus in surgical patients显示文摘 | Jack SD George M | 2002 | Diabetes Spectrum2002，15，： | 1 |
| 15 | Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian显示文摘BACKGROUND Multiple genetic risk factors for Crohn’s disease(CD)have been identified.However,these observations are not consistent across different populations.The protein tyrosine phosphate non-receptor type 2(PTPN2)gene plays a role in various aspects of host defense including epithelial barrier function,autophagy,and innate and adaptive immune response.Two common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)have been associated with risk of CD in Western countries.AIM To evaluate the association of PTPN2 gene polymorphisms with risk of CD in Indian population.METHODS We conducted a prospective case-control study.Patients with CD were recruited,and their clinical and investigation details were noted.Controls were patients without organic gastrointestinal disease or other comorbid illnesses.Two common polymorphisms in the PTPN2 gene(rs2542151 and rs7234029)were assessed.DNA was extracted from peripheral blood samples of cases and controls and target DNA was amplified using specific sets of primers.The amplified fragments were digested with restriction enzymes and the presence of polymorphism was detected by restriction fragment length polymorphism.The frequency of alleles was determined.The frequencies of genotypes and alleles were compared between cases and controls to look for significant differences.RESULTS A total of 108 patients with CD(mean age 37.5±12.7 years,females 42.6%)and 100 controls(mean age 39.9±13.5 years,females 37%)were recruited.For the single nucleotide polymorphism(SNP)rs7234029,the overall frequency of G variant genotype(AG or GG)was noted to be significantly lower in the cases compared to controls(35.2%vs 50%,P=0.05).For the SNP rs2542151,the overall frequency of G variant genotype(GT or GG)was noted to be similar in cases compared to controls(43.6%vs 47%,P=0.73).There were no significant differences in minor allele(G)frequency for both polymorphisms between the cases and controls.Both the SNPs had no significant association with age of onset of illness,gender,disease location,disease behaviour,perianal disease,or extraintestinal manifestations of CD.CONCLUSION Unlike observation form the West,polymorphisms in the PTPN2 gene(rs7234029 and rs2542151)are not associated with an increased risk of developing CD in Indian patients. | Kaushik Chatterjee Amit Kumar Dutta Ashish Goel Rekha Aaron Vijayalekshmi Balakrishnan Ajith Thomas Anoop John Rajeeb Jaleel Deepu David Reuben Thomas Kurien SD Chowdhury Ebby George Simon AJ Joseph Prasanna Premkumar Anna B Pulimood | 2022 | World Journal of Gastrointestinal Pathophysiology2022，13，4： | 0 |
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