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| 1 | 面向21世纪的卒中新定义:美国心脏病学会和美国卒中学会声明显示文摘尽管脑血管病有着全球性影响且对其病理生理学的认识有了很多进步,但是'卒中'这一术语在临床实践、临床研究或公共卫生评估中的定义却不一致。传统的定义依据于临床,却没有考虑到科学技术的进步。美国心脏协会(AHA)和美国卒中协会(ASA)卒中分会组织了写作小组,为21世纪卒中新定义撰写专家共识性声明。中枢神经系统(CNS)梗死,指由缺血所导致的脑、脊髓或视网膜的细胞死亡,是基于持续性损害的神经病理学、神经影像学和(或)临床证据。CNS梗死表现为一个临床谱:缺血性卒中特指伴有明显症状的CNS梗死,而静息性梗死根据定义指未引起已知的症状的梗死。卒中也还包括脑出血和蛛网膜下腔出血。新定义的卒中结合了临床和组织学标准,可被用于实践、研究和公共卫生评估。 | 俞羚 董荃 宋叶平 江静雯 李卉 刘亮贤 苏爱萍 李焰生 Sacco RL Kasner SE Broderick JP Caplan LR Connors JJ Culebras A Elkind MS George MG Hamdan AD Higashida RT Hoh BL Janis LS Kase CS Kleindorfer DO Lee JM Moseley ME Peterson ED Turan TN Valderrama AL Vinters HV | 2013 | 神经病学与神经康复学杂志2013，10，2： | 188 |
| 2 | Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion显示文摘Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion.Macrophage colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely understood.Here,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)fragments.Increased levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory responses.Moreover,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis model.The FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein expression.Moreover,targeting the MNK1/2 pathway diminished arthritic bone erosion.These results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion. | Se Hwan Mun Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun Park-Min | 2021 | Bone Research2021，9，4： | 2 |
| 3 | Nitric oxide synthase in atherosclerosis and vascular injury: insights from experimental genetherapy显示文摘 | CHANNON KM QIAN H GEORGE SE | 2000 | Arterioscler Thromb Vasc Biol2000，20，8： | 1 |
| 4 | Human Rhinoviruses显示文摘 | Jacobs SE Lamson DM St George K | 2013 | Clin Microbiol Rev2013，26，1： | 1 |
| 5 | Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells显示文摘 | Philipp Saiko Geraldine Graser Benedikt Giessrigl Marie-Thérèse Steinmann Heike Schuster Andreas Lackner Michael Grusch Georg Krupitza Walter Jaeger Venkateswarlu Somepalli Trimurtulu Golakoti Monika Fritzer-Szekeres Thomas Szekeres | 2013 | Investigational New Drugs2013，，5： | 1 |
| 6 | The disinfection by-products dichloro-,dibromo-,and bromochloroacetic acid impact intestinal and metabolism in fisher 344 rats upon exposure in drinking water显示文摘 | Nelson GM Swank AE | 2000 | Toxicological Science2000，56，： | 1 |
| 7 | Humoral and cellular immune responses to Ad2/CFTR-2显示文摘 | Kaplan JM St George JA Pennington SE | 2001 | Gene Ther2001，3，2： | 1 |
| 8 | Petroleum charge history in the Lunnan Low Uplift, Tarim Basin, China – Evidence from oil-bearing fluid inclusions显示文摘 | Se Gong Simon C. George Herbert Volk Keyu Liu Ping’an Peng | 2007 | Organic Geochemistry2007，，8： | 1 |
| 9 | Nitric oxide synthase in atherosclerosis and vascular injury显示文摘 | Channon KM Qian HS George SE | 2000 | Arterioscler Thromb Vasc Biol2000，20，： | 1 |
| 10 | Potentiation of GeneTransfer to the Mouse Lung by Complexes of Adenovirus Vector andPolycations Improves Therapeutic Potential 显示文摘 | Kaplan JM Pennington SE George J | 1998 | Hum Gene Ther1998，9，10： | 1 |
| 11 | Severe hypophosphatemia in a patient with acute pancreatitis显示文摘 | Evagelos R George A Moses SE | 2000 | Journal of the Pancreas2000，1，4： | 1 |
| 12 | Isolation and characterization of Urbain, a 20-hydroxyecdysone-inducible gene expressed during morphogenesis of Bombyx mori wing imaginal discs显示文摘 | Marie Thérèse Besson Pascal Chareyre Gilbert Deléage Jocelyne Demont Brigitte Quennedey Annie Courrent Jacques Fourche Georges Bosquet | 1996 | Roux’s Archives of Developmental Biology (-)1996，，7： | 1 |
| 13 | Improving neural network training solutions using regularisation显示文摘 | Seán Mc Loone George Irwin | 2001 | Neurocomputing2001，，1： | 1 |
| 14 | Innovative fluorescence spectroscopic techniques for rapidly characterising oil inclusions显示文摘 | Liu Keyu George SC Lu Xuesong Gong Se Tian Hua Gui Lili | 2014 | Organic Geochemistry2014，72，： | 1 |
| 15 | Humoral and cellular immune responses to Ad2/CFTR-2显示文摘 | St George JA Pennington SE | 1996 | Gene Ther1996，3，2： | 1 |
| 16 | Human rhi- novimses显示文摘 | Jacobs SE Lamson DM St George K | 2013 | Clin Microbiol Rev2013，26，1： | 1 |
| 17 | Acid phosphatase localization in seedling tissues of the palms, Phoenix dactylifera and Washingtonia filifera, and its relevance to controls of germination显示文摘 | Darleen AD Stillman JI George SE 1989 | 1989 | Canadian Journal ofBotany1989，67，： | 1 |
| 18 | The effect of ICER on screening methods involving CRE-mediated reporter gene expression显示文摘 | Kemp DM George SE Kent TC | 2002 | J Biomol Screen2002，7，2： | 1 |
| 19 | Role of gastrointestiinal mucosa and microflora in the bioactivation of dietary and environmental mutagens and carcinogens 显示文摘 | Chadwick RW George SE Claxton LD | 1992 | Dru Metabolism Rev1992，24，： | 1 |
| 20 | Nitric oxide synthase in atherosclerosis and vascular injury:insights from experimental gene therapy显示文摘 | Qian H George SE | 2000 | Arterioscler Thromb Vasc Biol2000，20，8： | 1 |
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