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| 1 | Duck egg drop syndrome virus:an emerging Tembusu-related flavivirus in China显示文摘Duck egg drop syndrome virus(DEDSV) is a newly emerging pathogenic flavivirus isolated from ducks in China.DEDSV infection mainly results in severe egg drop syndrome in domestic poultry,which leads to huge economic losses.Thus,the discovery of ways and means to combat DEDSV is urgent.Since 2010,a remarkable amount of progress concerning DEDSV research has been achieved.Here,we review current knowledge on the epidemiology,symptomatology,and pathology of DEDSV.A detailed dissection of the viral genome and polyprotein sequences,comparative analysis of viral antigenicity and the corresponding potential immunity against the virus are also summarized.Current findings indicate that DEDSV should be a distinct species from Tembusu virus.Moreover,the adaption of DEDSV in wildlife and its high homology to pathogenic flaviviruses(e.g.,West Nile virus,Japanese encephalitis virus,and dengue virus),illustrate its reemergence and potential to become a zoonotic pathogen that should not be overlooked.Detailed insight into the antigenicity and corresponding immunity against the virus is of clear significance for the development of vaccines and antiviral drugs specific for DEDSV. | LIU PeiPei LU Hao LI Shuang WU Ying George Fu GAO SU JingLiang | 2013 | Science China(Life Sciences)2013，56，8： | 28 |
| 2 | Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods:Association with particle constituents显示文摘Epidemiological studies have demonstrated the exacerbation of respiratory diseases following sandstorm-derived particulate matter(PM) exposure.The presence of anthropogenic and biological agents on the sandstorm PM and the escalation of PM < 2.5 μm(PM2.5)pollution in China have led to serious concerns regarding the health effects of PM2.5during Asian sandstorms.We investigated how changes in PM2.5composition,as the weather transitioned towards a sandstorm,affected human airway epithelial cells.Six PM2.5samples covering two sandstorm events and their respective background and transition periods were collected in Baotou,an industrial city near the Gobi Desert in China.PM samples from all three periods had mild cytotoxicity in human bronchial epithelial cell line BEAS-2B,which was positively correlated with the contents of polycyclic aromatic hydrocarbons and several metals.All PM samples potently increased the release of interleukin-6(IL-6) and interleukin-8(IL-8).Endotoxin in all samples contributed significantly to the IL-6 response,with only a minor effect on IL-8.Cr was positively correlated with both IL-6 and IL-8 release,while Si was only associated with the increase of IL-6.Our study suggests that local agricultural and industrial surroundings in addition to the sandstorm play important roles in the respiratory effects of sandstorm-derived PM. | Bin Wang Ning Li Furong Deng Nicholas Buglak George Park Shu Su Aiguo Ren Guofeng Shen Shu Tao Xinbiao Guo | 2016 | Journal of Environmental Sciences2016，28，9： | 9 |
| 3 | Resistin mediates the hepatic stellate cell phenotype显示文摘AIM: To describe the role of resistin in liver fibrosis. METHODS: For the in vivo animal study, Sprague Dawley rats were subjected to bile duct ligation (BDL) for 4 wk. Rat liver, adipose tissue (epididymal fat) and serum were analyzed for resistin expression. For the in vitro experiment, rat primary hepatic stellate cells (HSCs) and Kupffer cells (KCs) were used. HSCs were exposed to recombinant resistin, and collagenⅠ, transforming growth factor β1, α smooth muscle actin, tissue inhibitor of metalloproteinase 1 and connective tissue growth factor expression were analyzed. Resistin gene and protein expression was quantified as was the expression of pro-inflammatory cytokines including tumor necrosis factor α (TNFα), interleukin (IL)-1, IL-6, IL-8 and monocyte chemotactic protein-1 (MCP-1). The effects of resistin on HSC proliferation, migration and apoptosis were determined. The effects of resistin on KCs were also investigated. RESULTS: Following BDL, rat epididymal fat and serum rather than liver showed higher resistin expression compared to control rats. In liver, resistin was expressed in quiescent HSCs and KCs. Resistin treatment resulted in enhancement of TNFα , IL-6 , IL-8 and MCP-1 gene expression and increased IL-6 and MCP-1 protein in HSCs. Resistin activated HSC phospho-MAPK/p38, and p38 inhibition diminished IL-6 and MCP-1 expression. Furthermore, resistin facilitated HSC proliferation and migration, but decreased apoptosis which was via an IL-6 and MCP-1 mechanism. Finally, resistin-induced transforming growth factor β1 from KCs enhanced HSC collagenⅠexpression. CONCLUSION: Resistin directly and indirectly modulates HSC behavior towards a more pro-fibrogenic phenotype. | Zhi-Xia Dong Lin Su Joanne Brymora Claire Bird Qing Xie Jacob George Jian-Hua Wang | 2013 | World Journal of Gastroenterology2013，19，28： | 4 |
| 4 | Validation of Non-invasive Fibrosis Scores for Predicting Advanced Fibrosis in Metabolic-associated Fatty Liver Disease显示文摘Background and Aims:Metabolic-associated fatty liver disease(MAFLD)is a newly proposed terminology from 2020;yet,the applicability of conventional noninvasive fi-brosis models is still unknown for it.We aimed to evaluate the performance of conventional noninvasive fibrosis scores in MAFLD.Methods:The NHANES 2017-2018 datasets were used to compare the performances of different non-invasive fibrosis scores in MAFLD,including the aspartate aminotransferase(AST)to platelet ratio index(APRI),body mass index(BMI)-AST/alanine aminotransferase(ALT)ratio and diabetes score(BARD),fibrosis-4 index(FIB-4),and NAFLD fibrosis score(NFS).Moreover,Asian patients with biopsy-proven MAFLD were enrolled to further validate the findings.Results:A total of 2,622 participants in the Na-tional Health and Nutrition Examination Survey(NHANES)cohort and 293 patients with MAFLD in the Asian cohort were included.Patients in the Asian cohort had a lower BMI and higher liver enzymes(p<0.001).The area under the receiver operating characteristic curve(AUROC)of NFS was the largest in the NHANES cohort and Asian cohorts(0.679 and 0.699,respectively).The AUROC of NFS was followed by APRI,FIB-4,and BARD in the NHANES cohort(0.616,0.601,and 0.589,respectively).In the Asian cohort,the AUROC of APRI,FIB-4,and BARD for predicting advanced fibrosis were 0.625,0.683,and 0.615,respectively.The performance of FIB-4 was better in the Asian cohort than that in the NHANES cohort.Conclusions:NFS is better for predicting advanced fibrosis in MAFLD.FIB-4 can be an al-ternative choice for MAFLD with high liver enzymes when NFS is unavailable.Novel efficient noninvasive fibrosis scor-ing systems are highly required for patients with MAFLD. | Xiaoning Chen George Boon-Bee Goh Jiaofeng Huang Yinlian Wu Mingfang Wang Rahul Kumar Su Lin Yueyong Zhu | 2022 | Journal of Clinical and Translational Hepatology2022，10，4： | 4 |
| 5 | Development of Human in vitro Brain-blood Barrier Model from Induced Pluripotent Stem Cell-derived Endothelial Cells to Predict the in vivo Permeability of Drugs显示文摘An in vitro blood-brain barrier(BBB) model is critical for enabling rapid screening of the BBB permeability of the drugs targeting on the central nervous system.Though many models have been developed, their reproducibility and renewability remain a challenge. Furthermore, drug transport data from many of the models do not correlate well with the data for in vivo BBB drug transport.Induced-pluripotent stem cell(i PSC) technology provides reproducible cell resources for in vitro BBB modeling.Here, we generated a human in vitro BBB model by differentiating the human i PSC(hi PSC) line GM25256 into brain endothelial-type cells. The model displayed BBB characteristics including tight junction proteins(ZO-1,claudin-5, and occludin) and endothelial markers(von Willebrand factor and Ulex), as well as high transendothelial electrical resistance(TEER)(1560 X.cm2±230 X.cm2) and c-GTPase activity. Co-culture with primary rat astrocytes significantly increased the TEER of the model(2970 X.cm2 to 4185 X.cm2). RNAseq analysis confirmed the expression of key BBB-related genes in the hi PSC-derived endothelial cells in comparison with primary human brain microvascular endothelial cells,including P-glycoprotein(Pgp) and breast cancer resistant protein(BCRP). Drug transport assays for nine CNS compounds showed that the permeability of non-Pgp/BCRP and Pgp/BCRP substrates across the model was strongly correlated with rodent in situ brain perfusion data for these compounds(R2= 0.982 and R2= 0.9973,respectively), demonstrating the functionality of the drug transporters in the model. Thus, this model may be used to rapidly screen CNS compounds, to predict the in vivo BBB permeability of these compounds and to study the biology of the BBB. | Yuan Li Xueying Sun Houfu Liu Liang Huang Guofeng Meng Yu Ding Wenji Su Jiaqi Lu Sophie Gong Georg C.Terstappen Ru Zhang Wandong Zhang | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 6 | Serological Investigation of Laboratory-Confirmed and Suspected Ebola Virus Disease Patients During the Late Phase of the Ebola Outbreak in Sierra Leone显示文摘This study aimed to investigate the serological characteristics of Ebola virus(EBOV) infection during the late phase of the Ebola outbreak in Sierra Leone. In total, 877 blood samples from 694 suspected Ebola virus disease(EVD) cases assessed from March to December 2015, were analyzed via real-time reverse transcription polymerase chain reaction(RT-PCR) for viral RNA and enzyme-linked immunosorbent assay(ELISA) and Luminex to detect antibodies against EBOV. Viral load and EBOV-specific IgM/IgG titers displayed a declining trend during March to December 2015. Viral RNA load decreased rapidly at earlier stages after disease onset, while EBOV-specific IgM and IgG still persisted in 58.1%(18/31) and 93.5%(29/31) of the confirmed EVD patients and in 3.8%(25/663) and 17.8%(118/663) of the RNA-negative suspected patients in the later phase, respectively. Dynamic analysis of longitudinally collected samples from eight EVD patients revealed typically reversed trends of declining viral load and increasing IgM and/or IgG titers in response to the EBOV infection.The present results indicate that certain populations of Sierra Leone developed immunity to an EBOV infection in the late phase of the outbreak, providing novel insights into the risk assessment of EBOV infections among human populations. | Yang Liu YuLan Sun Wei Wu AQian Li XianDa Yang Shuo Zhang Chuan Li QiuDong Su ShaoJian Cai DaPeng Sun HaiYang Hu Zhe Zhang XiuXu Yang Idrissa Kamara Sheku Koroma Gerald Bangura Alie Tia Abdul Kamara Matt Lebby Brima Kargbo Jiandong Li Shiwen Wang XiaoPing Dong YueLong Shu WenBo Xu George F. Gao GuiZhen Wu DeXin Li William J. Liu MiFang Liang | 2018 | Virologica Sinica2018，33，4： | 2 |
| 7 | An analysis of urban development and its environmental impact on the Tampa Bay watershed显示文摘 | George Xian Mike Crane Junshan Su | 2006 | Journal of Environmental Management2006，，4： | 2 |
| 8 | Intra-project externality and layout variables in residential condominium appraisals 显示文摘 | Han Su S-H Michelle Chu George H L Ko W | 1998 | Journal of Real Estate Research1998，15，2： | 1 |
| 9 | Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data显示文摘 | Monique Maas Patty J Nelemans Vincenzo Valentini Prajnan Das Claus R?del Li-Jen Kuo Felipe A Calvo Julio García-Aguilar Rob Glynne-Jones Karin Haustermans Mohammed Mohiuddin Salvatore Pucciarelli William Small Javier Suárez George Theodoropoulos Sebastian | 2010 | Lancet Oncology2010，，9： | 1 |
| 10 | Long-term outcome in patients with a pathological complete response after chemoradiation for rectal cancer: a pooled analysis of individual patient data显示文摘 | Monique Maas Patty J Nelemans Vincenzo Valentini Prajnan Das Claus R?del Li-Jen Kuo Felipe A Calvo Julio García-Aguilar Rob Glynne-Jones Karin Haustermans Mohammed Mohiuddin Salvatore Pucciarelli William Small Javier Suárez George Theodoropoulos Sebastian | 2010 | Lancet Oncology2010，，9： | 1 |
| 11 | Absence of Integrin avb3 Enhances Vascular Leak in Mice by Inhibiting Endothelial Cortical Actin Formation显示文摘 | George Su Amha Atakilit | 2012 | Res Cri Care Med2012，185，： | 1 |
| 12 | Diaphragmatic rupture: A complication of violent cough显示文摘 | George L Rehman SU Khan FA | 2000 | Chest2000，117，4： | 1 |
| 13 | Global Transformations of Nonlinear Systems显示文摘 | Hunt L R Renjeng Su George Meyer | 1983 | IEEE Transactions on Automatic Control1983，28，1： | 1 |
| 14 | Effeets of phosphodiester- ase inhibitors on contraction induced by endothelin-1 of isolated human prostatic tissue 显示文摘 | George T Kedia SU Merab K | 2009 | Urology2009，73，6： | 1 |
| 15 | 双管反激式拓扑应对未来开关电源设计挑战显示文摘双管反激拓扑介绍
由于对环境问题的关注持续增加,这些年来高效率、低待机功耗的电源设计一直引人注目。近年来,业界使用软开关和谐振转换拓扑来应对高效率的挑战。然而,未来的低功耗、低成本和易于设计及制造方面的要求给日前的谐振拓扑带来巨大挑战。本文旨在介绍新的双开关管准谐振反激式转换器拓扑的工作原理和优点,并且使用一个90W的电源设计进行演示。 | George Lin Chris Su | 2012 | 今日电子2012，，10： | 1 |
| 16 | Contactless Growth of ZnSe Single Crystals by Physical Vapor Transport显示文摘 | Su C H George M A Palosz W | 2000 | Journal of Crystal Growth2000，213，34： | 1 |
| 17 | Housekeeping gene variability in normal and cancerous colorectal, pancreatic, esophageal, gastric and hepatic tissues显示文摘 | Claudia Rubie Katja Kempf Joachim Hans Tiefen Su Bettina Tilton Thomas Georg Brigitte Brittner Bianca Ludwig Martin Schilling | 2004 | Molecular and Cellular Probes2004，，2： | 1 |
| 18 | Inhibition ofautophagic turnover in β-cells by fatty acids and glucoseleads to apoptotic cell death显示文摘 | Mir SU George NM Zahoor L | 2015 | J Biol Chem2015，290，10： | 1 |
| 19 | Diaphragmatic rupture:a complication of violent cough显示文摘 | George L R ehman SU Khan FA | 2000 | Chest2000，117，： | 1 |
| 20 | Impaired Hepatocyte Regeneration in Toll-Like Receptor 4 Mutant Mice显示文摘 | Grace L. Su Stewart C. Wang Alireza Aminlari George L. Tipoe Lars Steinstraesser Amin Nanji | 2004 | Digestive Diseases and Sciences2004，，5： | 1 |
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