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| 1 | Meta-analysis of laparoscopic vs open cholecystectomy in elderly patients显示文摘AIM:To investigate the comparative effect of laparoscopic and open cholecystectomy in elderly patients.METHODS:Laparoscopic cholecystectomy has induced a revolution in the treatment of gallbladder disease.Nevertheless,surgeons have been reluctant to implement the concepts of minimally invasive surgery in older patients.A systematic review of Medline was embarked on,up to June 2013.Studies which provided outcome data on patients aged 65 years or older,subjected to laparoscopic or open cholecystectomy were considered.Mortality,morbidity,cardiac and pulmonary complications were the outcome measures of treatment effect.The methodological quality of selected studies was appraised using valid assessment tools.Τhe random-effects model was applied to synthesize outcome data.RESULTS:Out of a total of 337 records,thirteen articles(2 randomized and 11 observational studies)reporting on the outcome of 101559 patients(48195in the laparoscopic and 53364 in the open treatment group,respectively)were identified.Odds ratios(OR)were constantly in favor of laparoscopic surgery,in terms of mortality(1.0%vs 4.4%,OR=0.24,95%CI:0.17-0.35,P<0.00001),morbidity(11.5%vs 21.3%,OR=0.44,95%CI:0.33-0.59,P<0.00001),cardiac(0.6%vs 1.2%,OR=0.55,95%CI:0.38-0.80,P=0.002)and respiratory complications(2.8%vs 5.0%,OR=0.55,95%CI:0.51-0.60,P<0.00001).Critical analysis of solid study data,demonstrated a trend towards improved outcomes for the laparoscopic concept,when adjusted for age and co-morbid diseases.CONCLUSION:Further high-quality evidence is necessary to draw definite conclusions,although bestavailable evidence supports the selective use of laparoscopy in this patient population. | Stavros A Antoniou George A Antoniou Oliver O Koch Rudolph Pointner Frank A Granderath | 2014 | World Journal of Gastroenterology2014，20，46： | 17 |
| 2 | 28例转移性肝癌腹腔镜肝切除术显示文摘目的总结转移性肝癌的腹腔镜肝切除术经验。方法对1999—2006年度布里斯班医院所实施的转移性肝癌腹腔镜肝切除术病人进行回顾性研究。结果经病理证实的28例转移性肝癌病人进行了腹腔镜肝切除,13例进行左肝外侧叶切除,9例进行了右半肝切除。其余6例行肝段或不规则切除。追踪随访12例由直结肠转移的转移性肝癌病人2年存活率和无瘤生存率分别为75%和67%。结论在严格选择过的恶性肿瘤病人中行腹腔镜肝切除术是安全可行的。对病人要有适当的分期.术者需具丰富的开腹肝切除术经验和腹腔镜操作技能。 | 吴志明 Nick O'Rourke Lan Shaw Les Nathanson Lan Martin George Fielding | 2009 | 中华肝胆外科杂志2009，15，12： | 8 |
| 3 | 缩短渗碳周期与强烈淬火相结合的节能热处理技术(英文)显示文摘在热处理行业,人们一直在探索降低生产成本、节约能源和减少环境污染的方法。汽车制造业在这方面将是大有作为的,其中包括:大幅度缩短渗碳时间,以节能和降低生产成本;开发新型淬火剂替代易燃、有毒的矿物油基淬火剂。采用非易燃的对环境友好的水基淬火剂进行强烈淬火(IQ)是达到这些目标的途径之一。此外,IQ还能使渗碳的扩散时间缩短50%或更多。本文论述了巴西圣保罗大学、巴西Combustol公司以及美国强烈淬火公司合作进行的采用一种强烈淬火工艺成功达到上述目标的研究成果。从长远看,这些成果对热处理工业将具有重要意义。 | Lauralice C.F.Canale Eduardo Merheb Joo C.Vendramim George E.Totten | 2007 | 热处理2007，22，2： | 4 |
| 4 | 手术中知晓事件的新分级标准显示文摘背景有外显记忆的手术中知晓事件的发生率仅为1/1000—2/1000。因其较罕见,为了更好的了解手术中知晓事件及其后遗效直,需要对大批量的研究数据进行统计。因此,对其进行标准描述和表达将很有价值。方法本研究创建了一种新的手术中知晓事件评估标准:0级:未发生手术中知晓;1级:仅存在听觉感知;2级:感知触觉(比如手术操作、气管插管);3级:感知痛觉;4级:感知麻痹(比如感到不能活动、说话或呼吸);5级:感知麻痹及痛觉。患者主述有恐惧、焦虑、窒息、末日感、濒死感及其他相关显性描述,另行附加“D”(distress[痛苦、悲伤])。本研究回顾了15项详细提供手术中知晓报告信息的研究。来自3个研究并创建了该项分级标准的5位麻醉医生,各自独立的评估了这些病例。另外20名相关人员(麻醉主治医生、麻醉住院医生、麻醉护士、医学生及其辅助工作人员),虽未参与该分级标准的创建,但也独立对手术中知晓事件进行了评估。用Flwiss’s κ系数评估观察者之间的一致性。结果对151例确认发生手术中知晓事件的成年病例进行数据分析。基础评估1~5级中,总体κ系数为0.851(95%可信区间CI0.847~0.856)。包括附加情感障碍“D”的评估中,总体κ系数为0.779(95%可信区间CI 0.776~0.783)。结论本研究创建了新的手术中知晓事件评估标准,在评估者间具有近乎完美的一致性,这将有助于手术中知晓事件的研究。 | George A. Mashour Roy K. Esaki Kevin K. Tremper David B. Glick Michael O'Connor Michael S. Avidan 潘鹏(译) 李文志(校) | 2009 | 麻醉与镇痛2009，，6： | 3 |
| 5 | Gastric per-oral endoscopic myotomy: Current status and future directions显示文摘Gastroparesis, or symptomatic delayed gastric emptying in the absence of mechanical obstruction, is a challenging and increasingly identified syndrome. Medical options are limited and the only medication approved by the Food and Drug Administration for treatment of gastroparesis is metoclopramide, although other agents are frequently used off label. With this caveat, first-line treatments for gastroparesis include dietary modifications, antiemetics and promotility agents, although these therapies are limited by suboptimal efficacy and significant medication side effects. Treatment of patients that fail first-line treatments represents a significant therapeutic challenge. Recent advances in endoscopic techniques have led to the development of a promising novel endoscopic therapy for gastroparesis via endoscopic pyloromyotomy, also referred to as gastric per-oral endoscopic myotomy or per-oral endoscopic pyloromyotomy. The aim of this article is to review the technical aspects of the per-oral endoscopic myotomy procedure for the treatment of gastroparesis, provide an overview of the currently published literature, and outline potential next directions for the field. | Alexander Podboy Joo Ha Hwang Linda A Nguyen Patricia Garcia Thomas A Zikos Afrin Kamal George Triadafilopoulos John O Clarke | 2019 | World Journal of Gastroenterology2019，25，21： | 3 |
| 6 | Reslizumab in children and adolescents with eosinophilic esophagitis: Results of a double-blind, randomized, placebo-controlled trial显示文摘 | Jonathan M. Spergel Marc E. Rothenberg Margaret H. Collins Glenn T. Furuta Jonathan E. Markowitz George Fuchs Molly A. O’Gorman Juan Pablo Abonia James Young Timothy Henkel H. Jeffrey Wilkins Chris A. Liacouras | 2012 | The Journal of Allergy and Clinical Immunology2012，，： | 3 |
| 7 | Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis显示文摘 | Helen M. Parker Nathan A. Johnson Catriona A. Burdon Jeffrey S. Cohn Helen T. O’Connor Jacob George | 2011 | Journal of Hepatology2011，，4： | 3 |
| 8 | Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth显示文摘 | Michael S O’Reilly Thomas Boehm Yuen Shing Naomi Fukai George Vasios William S Lane Evelyn Flynn James R Birkhead Bjorn R Olsen Judah Folkman | 1997 | Cell1997，，2： | 3 |
| 9 | Omentum facilitates liver regeneration显示文摘AIM:To investigate the mechanism of liver regeneration induced by fusing the omentum to a small traumatic injury created in the liver. We studied three groups of rats. In one group the rats were omentectomized; in another group the omentum was left in situ and was not activated,and in the third group the omentum was activated by polydextran particles. METHODS:We pre-activated the omentum by injecting polydextran particles and then made a small wedge wound in the rat liver to allow the omentum to fuse to the wound. We monitored the regeneration of the liver by determining the ratio of liver weight/body weight,by histological evaluation (including immune staining for cytokeratin-19,an oval cell marker),and by testing for developmental gene activation using reverse transcription polymerase chain reaction (RT-PCR). RESULTS:There was no liver regeneration in the omentectomized rats,nor was there significant regeneration when the omentum was not activated,even though in this instance the omentum had fusedwith the liver. In contrast,the liver in the rats with the activated omentum expanded to a size 50% greater than the original,and there was histologically an interlying tissue between the wounded liver and the activated omentum in which bile ducts,containing cytokeratin-19 positive oval cells,extended from the wound edge. In this interlying tissue,oval cells were abundant and appeared to proliferate to form new liver tissue. In rats pre-treated with drugs that inhibited hepatocyte growth,liver proliferation was ongoing,indicating that regeneration of the liver was the result of oval cell expansion. CONCLUSION:Activated omentum facilitates liver regeneration following injury by a mechanism that depends largely on oval cell proliferation. | Ashok K Singh Nishit Pancholi Jilpa Patel Natalia O Litbarg Krishnamurthy P Gudehithlu Perianna Sethupathi Mark Kraus George Dunea Jose AL Arruda | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 10 | Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles显示文摘 | Liam O’Mahony Jane McCarthy Peter Kelly George Hurley Fangyi Luo Kersang Chen Gerald C. O’Sullivan Barry Kiely J. Kevin Collins Fergus Shanahan Eamonn M.M. Quigley | 2005 | Gastroenterology2005，，3： | 2 |
| 11 | Mechanisms of biofilm resistance to antimicrobial agents显示文摘 | Thien-Fah C Mah George A O’Toole | 2001 | Trends in Microbiology2001，，1： | 2 |
| 12 | Metafrontier frameworks for the study of firm-level efficiencies and technology ratios显示文摘 | Christopher J. O’Donnell D. S. Prasada Rao George E. Battese | 2008 | Empirical Economics2008，，2： | 2 |
| 13 | Lessons from look-back in acute liver failure? A single centre experience of 3300 patients显示文摘 | William Bernal Anna Hyyrylainen Amit Gera Vinod K. Audimoolam Mark J.W. McPhail Georg Auzinger Mohammed Rela Nigel Heaton John G. O’Grady Julia Wendon Roger Williams | 2013 | Journal of Hepatology2013，，1： | 2 |
| 14 | A Metafrontier Production Function for Estimation of Technical Efficiencies and Technology Gaps for Firms Operating Under Different Technologies显示文摘 | George E. Battese D. S. Prasada Rao Christopher J. O’Donnell | 2004 | Journal of Productivity Analysis2004，，1： | 2 |
| 15 | Metafrontier frameworks for the study of firm-level efficiencies and technology ratios显示文摘 | Christopher J. O'Donnell D. S. Prasada Rao George E. Battese | 2008 | Empirical Economics2008，，2： | 2 |
| 16 | 体外评估自酸蚀粘结剂的釉质封闭能力显示文摘目的:尽管有报道自酸蚀釉质粘合剂存在粘结不足的缺陷.自酸蚀粘结剂的应用在不断扩大.有些临床医师选择单独酸蚀釉质以弥补其缺陷。本研究目的是评估3种自酸蚀粘结剂在热疲劳后,酸蚀对釉质封闭的影响。材料与方法:取30颗牛切牙,在每颗牙上预备两个箱状洞型,分别用Adper Prompt L-Pop(3MESPE)、Clearfil SE Bond(Kuraray America)和iBond(Heraeus Kulzer)这三种自酸蚀粘结剂中的一种处理窝洞。其中部分先用磷酸酸蚀釉质,另一部分直接涂布自酸蚀粘结剂,然后用FiltekZ250(3MESPE)充填洞型。然后取一半的充填体置于1500个热循环中使之疲劳,再用50%硝酸氨银来检验材料的边缘封闭能力。银离子渗透按O~4分级.材料界面通过黑点探测器在发散区域扫描电镜(FESEM)下分析。用非参数统计计算出一个95%的可信区间。结果:Clearfil SE Bond的釉质微渗漏显著低于另两个自酸蚀粘结剂。对置于热循环后的标本,酸蚀能显著降低所有自酸蚀粘结剂的银离子渗透。对没有经过热循环的标本,酸蚀只能减少iBond的银离子渗透。在FESEM下.银离子沉淀可被发现位于Adper Prompt L-Pop和iBond的粘结层中.而Clearfil SE Bond处理后的10个标本中只有2个表现出银离子沿釉质粘结界面渗透。结论:标本在热循环疲劳状态.磷酸酸蚀能提高3种自酸蚀粘结剂的釉质边缘封闭能力。 | Jorge Perdigǎo Paulo Monteiro George Gomes 李珍(译) | 2009 | 中国口腔医学继续教育杂志2009，，4： | 2 |
| 17 | Ischemic Stroke Subtypes: A Population-Based Study of Functional Outcome, Survival, and Recurrence显示文摘 | George W. Petty Robert D. Brown Jack P. Whisnant JoRean D. Sicks W. Michael O’Fallon David O. Wiebers | 2000 | Stroke: Journal of the American Heart Association2000，，5： | 2 |
| 18 | Fluorescence kinetics of aqueous solutions of tetracycline and its complexes with Mg^3+ and Ca^2+ 显示文摘 | SIEGFRIED S MATTHIAS O S GEORG B | 2003 | Photochem Photobiol Sci2003，2，11： | 1 |
| 19 | Effects of tungsten substitution on the transport properties and mechanism of fast oxide-ion conduction in La2 Mo2 O9 显示文摘 | Georges S Bohnke O Goutenoire F | 2006 | Solid State Ionies2006，177，： | 1 |
| 20 | Predictors of extubation failure in patients with chronic obstructive pulmonary disease显示文摘 | Robriquet L Georges H Leroy O | 2006 | J Crit Care2006，21，2： | 1 |
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