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| 1 | Potential implications of Helicobacter pylori-related neutrophil-activating protein显示文摘Helicobacter pylori (H.pylori) virulence factors promote the release of various chemoattractants/inflammatory mediators,including mainly the neutrophilattractant chemokine interleukin-8 and neutrophilactivating protein (NAP),involved in H.pylori-induced gastric pathologies.Co-administration of Chios mastic gum (CMG),which inhibits H.pylori NAP,with an H.pylori eradication regimen might add clinical benefits against H.pylori-related gastric pathologies,but possibly not CMG as main therapy.Although H.pylori NAP and other H.pylori-related cytotoxins [i.e.,vaculating cytotoxin (VacA)] appear to play a major role in generating and maintaining the H.pylori-associated gastric inflammatory response and H.pylori NAP is a promising vaccine candidate against H.pylori infection (H.pylori-I),concerns regarding its potential drawbacks,particularly neurogenic ones,due to possible crossmimicry,should be considered.Possible cross-mimicry between H.pylori NAP and/or bacterial aquaporin (AQP) and neural tissues may be associated with the anti-AQP-4 antibody-related neural damage in multiple sclerosis (MS)/neuromyelitis optica patients.Moreover,the sequence homology found between H.pylori VacA and human Na+/K+-ATPase A subunit suggests that antibodies to VacA involve ion channels in abaxonal Schwann cell plasmalemma resulting in demyelination in some patients.A series of factors have been implicated in inducing blood-brain barrier (BBB) disruption,including inflammatory mediators (e.g.,cytokines and chemokines induced by H.pylori-I) and oxidative stress.BBB disruption permits access of AQP4-specific antibodies and T lymphocytes to the central nervous system,thereby playing a major role in multiple sclerosis pathogenesis.Relative studies show a strong association between H.pylori-I and MS.H.pylori-I induces humoral and cellular immune responses that,owing to the sharing of homologous epitopes (molecular mimicry),cross-react with components of nerves,thereby contributing and perpetuating neural tissue damage.Finally,H.pylori NAP also plays a possible pathogenetic role in both gastric and colon oncogenesis. | Jannis Kountouras Christos Zavos Georgia Deretzi Emmanuel Gavalas Dimitrios Chatzopoulos Panagiotis Katsinelos Elena Tsiaousi Stergios Gagalis Stergios A Polyzos Ioannis Venizelos | 2012 | World Journal of Gastroenterology2012，18，5： | 5 |
| 2 | Comment on “Effect of biofilm formation by clinical isolates of Helicobacter pylori on the efflux-mediated resistance to commonly used antibiotics”显示文摘Attaran et al[1] have recently shown that decreased susceptibility of established Helicobacter pylori(H. pylori) biofilms to specific antibiotics,was associated with the overtly enhanced transcription of two efflux pump genes,hp1165 and hef A,involved in specific resistance to tetracycline and multiple antibiotics,respectively. Apart from antibiotic exposure,secretion of multiple antimicrobial peptides,such as human β-defensins(hβDs),by the gastric epithelium upon Hp challenge,may act as early triggering events that positively impact biofilm formation and thus,antibiotic resistance. In this regard,we undertook genomic transcriptional studies using Hp 26695 strain following exposure to sublethal,similar to those present in the gastric niche,concentrations of hβDs in an attempt to provide preliminary data regarding possible mechanisms of immune evasion and selective sensitivity of Hp. Our preliminary results indicate that hβD exposure ignites a rapid response that is largely due to the activation of several,possibly interconnected transcriptional regulatory networks – origons-that ultimately coordinate cellular processes needed to maintain homeostasis and successful adaptation of the bacterium in the gastric environment. In addition,we have shown that both antibiotic and hβD resistance are mediated by dedicated periplasmic transporters,including the aforementioned efflux pump genes hp1165 and hef A,involved in active export of antibiotics from the cell membrane and/or,as recently suggested,substrate sensing and signalling. Furthermore,itappears that sublethal doses of hβDs may enhance biofilm formation by the sustained expression of,mainly,quorum sensing-related genes. In conclusion,we provide additional data regarding the role of specific innate immune molecules in antibiotic cross-resistance mechanisms that may deepen our understanding in the context of the development of novel eradication regimens. | Evangelos I Kazakos Nick Dorrell Stergios A Polyzos Georgia Deretzi Jannis Kountouras | 2017 | World Journal of Gastroenterology2017，23，33： | 3 |
| 3 | Cooling for acute ischemic brain damage (cool aid):an open pilot study of induced hypothermia in acute ischemic stroke显示文摘 | Krieger D W De Georgia M A Abou-Chebl A | 2001 | Stroke2001，32，： | 1 |
| 4 | Fever is associated with third ventricular shift after intracerebral hemorrhage: pathophysiologic implications 显示文摘 | Deogaonkar A De Georgia M Bae C | 2005 | Neurol India2005，53，2： | 1 |
| 5 | Cooling for Acute Ischemic Brain Damage(COOL AID):a feasibility trial of en- dovascular cooling显示文摘 | De Georgia MA Krieger DW Abou-Chebl A | 2004 | Neurology2004，63，2： | 1 |
| 6 | Preventing transmission of blood-borne pathogens: a compelling argument for effective deviceselection strategies 显示文摘 | Culver J Georgia A | 1997 | Am-c-InFEct-Conpaol1997，25，5： | 1 |
| 7 | Multimodal monitoring in the neurelogical intensive card unit 显示文摘 | De Georgia MA Deogaonkar A | 2005 | Neurologist2005，11，1： | 1 |
| 8 | The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection显示文摘 | Sheldon P Stone Ben S Cooper Chris C Kibbler Barry D Cookson Jenny A Roberts Graham F Medley Georgia Duckworth Rosalind Lai Shah Ebrahim Erwin M Brown Phil J Wiffen Peter G Davey | 2007 | The Lancet Infectious Diseases2007，，4： | 1 |
| 9 | Cooling for Acute lschemic Brain Damage(COOL AID):an open pilot study of induced-hypothermia in acute ischemic stroke显示文摘 | Krieger DW De Georgia MA Abou-Chebl A | | 0，，： | 1 |
| 10 | Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis 显示文摘 | Andrea Cipriani Toshiaki A Furukawa Georgia Salanti | 2009 | Lancet2009，373，： | 1 |
| 11 | IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis显示文摘 | Malamut Georgia El Machhour Raja Montcuquet Nicolas Martin-Lannerée Séverine Dusanter-Fourt Isabelle Verkarre Virginie Mention Jean-Jacques Rahmi Gabriel Kiyono Hiroshi Butz Eric A Brousse Nicole Cellier Christophe Cerf-Bensussan Nadine Meres | 2010 | Journal of Clinical Investigation2010，，6： | 1 |
| 12 | Disturbances of Acquired Immunity in Hemodialysis Patients显示文摘 | Theodoros E Georgia A Vassilios Liakopoulos | 2007 | Seminars in Dialysis2007，20，： | 1 |
| 13 | Probiotic potential of Lactobacillus strains isolated from dairy products显示文摘 | Petros A Marakoudakisa Georgia zoumpoponloua | 2006 | International Dairy Journal2006，16，3： | 1 |
| 14 | Biohydrogen and meth- ane production from cheese whey in a two - stage anaerobic process 显示文摘 | Georgia A Katerina S Nikolaos V | 2008 | Industrial & Engineering Chemistry Research2008，47，15： | 1 |
| 15 | Cooling for acute isehemic brain damage ( COOL AID ) : a feasi- bility trial of endovaseular cooling 显示文摘 | De Georgia MA Krieger DW Abou-Chebl A | 2004 | Neurology2004，63，2： | 1 |
| 16 | Acupressure on the extra 1 acupoint: the effect on bispectral index, ser- um melatonin, plasma 15-endorphin, and stress 显示文摘 | Fassoulaki A Paraskeva A Georgia K | 2007 | Anesth Analg2007，104，2： | 1 |
| 17 | Comparative efficacy and acceptability of 12 new-generation anti- depressants : a multiple-treatments meta-analysis 显示文摘 | Andrea Cipriani Toshiaki A Furukawa Georgia Salanti | 2009 | The Lancet2009，373，9665： | 1 |
| 18 | SI alleles in broccoli显示文摘 | Georgia A V S Ockendon D J Gabrielson R L | 1982 | HortSci1982，17，5： | 1 |
| 19 | P27 regulates the transition of betacells from quiescence to proliferation 显示文摘 | GEORGIA S BHUSHAN A | 2006 | Diabetes2006，55，： | 1 |
| 20 | Cooling for acute ischemic brain damage (cool aid):an open pilot study of induced hypothermia in acute ischemic stroke显示文摘 | De Georgia MA Abou-Chebl A | 2001 | Stroke2001，32，： | 1 |
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