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| 1 | Diabetes mellitus increases the prevalence of anemia in patients with chronic kidney disease:A nested case-control study显示文摘AIM: To compare anemia prevalence between matched chronic kidney disease(CKD) patients with and without diabetes mellitus(DM) and to assess factors associated with anemia development.METHODS: This is a nested case-control study of 184 type-2 diabetic and 184 non-diabetic CKD patients from a prospectively assembled database of a Nephrology outpatient clinic, matched for gender, age and estimated glomerular filtration rate(eG FR). Prevalence of anemia(hemoglobin: Men: < 13 g/dL, women: < 12 g/dL and/or use of recombinant erythropoietin) was examined in comparison, in the total population and by CKD Stage. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with anemia.RESULTS: The total prevalence of anemia was higher in diabetics(47.8% vs 33.2%, P = 0.004). Accordingly, prevalence was higher in diabetics in CKD Stage 3(53.5% vs 33.1%, P < 0.001) and particularly in Stage 3a(60.4% vs 26.4%, P < 0.001), whereas it was nonsignificantly higher in Stage 4(61.3% vs 48.4%; P = 0.307). Serum ferritin was higher in diabetics in total and in CKD stages, while serum iron was similar between groups. In multivariate analyses, DM(OR = 2.206, 95%CI: 1.196-4.069), CKD Stages 3a, 3b, 4(Stage 4: OR = 12.169, 95%CI: 3.783-39.147) and serum iron(OR = 0.976, 95%CI: 0.968-0.985 per mg/d L increase) were independently associated with anemia.CONCLUSION: Prevalence of anemia progressively increases with advancing stages of CKD and is higher in diabetic than matched non-diabetic CKD patients and diabetes is independently associated with anemia occurrence. Detection and treatment of anemia in diabetic CKD patients should be performed earlier than non-diabetic counterparts. | Charalampos Loutradis Alexandra Skodra Panagiotis Georgianos Panagiota Tolika Dimitris Alexandrou Afroditi Avdelidou Pantelis A Sarafdis | 2016 | World Journal of Nephrology2016，5，4： | 9 |
| 2 | Oral magnesium supplementation reduces ambulatory blood pressure in patients with mild hypertension显示文摘 | Hatzistavri LS Sarafidis PA Georgianos PI | 2009 | Am J Hypertens2009，22，10： | 1 |
| 3 | Low-dose atorvastatin reduces ambulatory blood pressure in patients with mild hypertension and hypercholesterolaemia: a double-blind, randomized,placebo-controlled study 显示文摘 | KANAKI A I SARAFIDIS P A 'GEORGIANOS P I | 2012 | J Hum Hypertens2012，26，10： | 1 |
| 4 | Effect of thiazolidinediones on albuminuria and proteinuria in diabetes:a meta-analysis显示文摘 | Sarafidis PA Stafylas PC Georgianos PI | | 0，，： | 1 |
| 5 | Effects of lowdose atorvastatin on arterial stiffness and central aortic pressure augmentation in patients with hypertension and hypercholesterolemia显示文摘 | Kanaki AI Sarafidis PA Georgianos PI | 2013 | Am J Hypertens2013，26，5： | 1 |
| 6 | Effects of low-dose atorvastatin on arterial stiffness and central aortic pressure augmentation in patients with hypertension and hyper- cholesterolemia显示文摘 | Kanaki AI Sarafidis PA Georgianos PI | 2013 | Am J Hyperten2013，26，5： | 1 |
| 7 | Beneficial effects of oral magnesium supplementation on insulin sensitivity and serum lipid profile 显示文摘 | Hadjistavri LS Sarafidis PA Georgianos PI Tziolas IM Aroditis CP Hitoglou-Makedou A Zebekakis PE Pikilidou MI Lasaridis AN | 2010 | Medieal Science Monitor: International Medical Journal Of Experimental And Clinical Research2010，16，6： | 1 |
| 8 | Resistant hyperten- sion its identification and epidemiology显示文摘 | Sarafidis PA Georgianos P Bakris GL | 2013 | Nat Rev Nephrol2013，9，1： | 1 |
| 9 | Effect of thiazolidinediones on albuminuria and proteinuria in diabetes:a meta-analysis显示文摘 | Sarafidis P A Stafylas P C Georgianos P l | 2010 | Am J Kidney Dis2010，55，5： | 1 |
| 10 | Low - dose atorvastatin reduces ambulatory blood pressure in patients with mild hypertension and hypercholesterolaemia , a double - blind, randomized, placebo - controlled study 显示文摘 | Kanaki AI Sarafidis PA Georgianos PI et at | 2012 | J Hum Hypertension2012，26，： | 1 |
| 11 | Effects of low-dose atorvastatin on arterial stiffness and central aortic pressure augmentation in patients with hypertension and hyper - cholesterolemia 显示文摘 | Kanaki AI Sarafidis PA Georgianos PI | 2013 | Am J Hypertens2013，26，5： | 1 |
| 12 | Effect of thiazolidinediones on albuminuria and proteinuria in diabetes: a meta-analysis 显示文摘 | Sarafidis P A Stafylas P C Georgianos P I | 2010 | Am J Kidney Dis2010，55，5： | 1 |
| 13 | Intractable hypertension--its identification and epidemiology显示文摘 | Sarafidis PA1 Georgianos P Bakris G L | 2013 | Nat Rev Nephrol2013，9，1： | 1 |
| 14 | PPAR-gamma agonism for cardiovascular and renal protection显示文摘 | Sarafidis PA Georgianos PI Lasaridis AN | 2011 | Cardio- vasc Ther2011，29，6： | 1 |
| 15 | Effects of low-dose atorv- astatin on arterial stiffness and central aortic pressure augmentation in patients with hypertension and hypercholesterolemia 显示文摘 | Kanaki AI Sarafidis PA Georgianos PI | 2013 | Am J Hyper- tens2013，62，5： | 1 |
| 16 | Low-dose atorvastatin reduces ambulatory blood pressure in patients with mild hypertension and hypercholesterolaemia:a double-blind,randomized,placebo-controlled study显示文摘 | Kanaki AI Sarafidis PA Georgianos PI | 2012 | J Hum Hypertens2012，26，10： | 1 |
| 17 | Beneficial effects of oral magnesium supplementation on insulin sensitivity and serum lipid profile显示文摘 | Hadjistavri LS Sarafidis PA Georgianos PI | | 0，，： | 1 |
| 18 | Effects of low-dose ator- vastatin on arterial stiffness and central aortic pressure augmenta- tion in patients with hypertension and bypercholesterolemia 显示文摘 | Kanaki A Sarafidis P Georgianos P | 2013 | American journal of hypertension2013，5，： | 1 |
| 19 | Effect of thiazo- lidinediones on albuminuria and proteinuria in diabetes: a meta-a- nalysis显示文摘 | Sarafidis P A Stafylas P C Georgianos P I | 2010 | Am J Kidney Dis2010，55，5： | 1 |
| 20 | Low-dose atorvastatin reduces ambulatory blood pressure in patients with mild hypertension and hypercholesterolaemia : a double-blind, randomized, placebo-con- trolled study显示文摘 | Kanaki AI Sarafidis PA Georgianos PI | 2012 | J Hum Hypertens2012，26，10： | 1 |
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