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| 1 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 2 | Synthesis and Crystal Structure of Supramolecular Adducts of Macrocyclic Cavitand Cucurbituril with Chromium(III) and Nickel(II) Aqua Complexes显示文摘 | SAMSONENKO D G GERASKO O A MITKINA T V | 2003 | Russian Journal of Coordination Chemistry2003，29，3： | 1 |
| 3 | Middle lobe syndrome: an extraordinary presentation of endobronchial tuberculosis 显示文摘 | Garg T Gera K Shah A | 2015 | Pneumonol Alergol Pol2015，83，5： | 1 |
| 4 | Effect of iron supplementation on mental and motor development in children: systematic review of randomized controlled trials显示文摘 | SACHDEV H GERA T NESTEL P | 2005 | Public Health Nutr2005，8，： | 1 |
| 5 | Strategies for circulation evaluation of aircraft wake vortex measured by lidar 显示文摘 | Holzapfel F Gera T Kopp F | 2003 | Journal of Atmospheric and Oceanic Technology2003，20，8： | 1 |
| 6 | Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials显示文摘 | Sachdev H Gera T Nestel P | 2005 | Public Health Nutr2005，8，2： | 1 |
| 7 | Effect of iron supplementation of mental and motor development in children: systematic review randomized controlled !rials显示文摘 | Sachdev H Gera T Nestel P | 2005 | Pub Health Nutr2005，8，： | 1 |
| 8 | Multiple micronutri- ent supplementation for improving cognitive performance in children: Systematic review of randomized controlled trials 显示文摘 | EILANDER A GERA T SACHDEV HS | 2010 | Am J Clin Nu- tr2010，91，1： | 1 |
| 9 | Determination of the frequencies of re- storer and maintainer-alleles involved inCMS1 and CMS2 in German chive vari- eties 显示文摘 | ENGELKE T GERA D TATLIOGLU T | 2004 | Plant Breeding2004，123，1： | 1 |
| 10 | Effect of iro supplementation of mental and motor development in children:systematic review randomized controlled controlled trials显示文摘 | Sachdev H Gera T Nestel P | 2005 | Pub Health Nutr2005，8，： | 1 |
| 11 | Effect of iron supplementation on mental and motor development in children:systematic review of randomized controlled trials显示文摘 | SACHDEV H GERA T NESTEL P | 2005 | Public Health Nutr2005，8，2： | 1 |
| 12 | Efficient genetic transformation of Lilium longiflorum and Ornithogalum dubium by particle acceleration followed by prolonged selection in liquid medium显示文摘 | COHEN A LIPSKY A ARAZI T ION A STAV R SANDLER ZIV D PINTEA C BARG R SALTS Y SHABTAI S GABA V GERA A | 2004 | Acta Horticulturae2004，651，2： | 1 |
| 13 | Effect of iron supplementation on mental and motor development in children:systematic review of randomized controlled trials显示文摘 | Sachdev H Gera T Nestel P | 2005 | Public Health Nutr2005，8，2： | 1 |
| 14 | Multiple micronu trient supplementation for improving cognitive performance in children: systematic review of randomized controlled trials 显示文摘 | Eilander A Gera T Sachdev HS | 2010 | Am J Clin Nutr2010，91，11： | 1 |
| 15 | Effect of combining multiple micronutrients with iron supplementation on Hb response in children:systematic review of randomized controlled trials显示文摘 | Gera T Sachdev HP Nestel P | | 0，，06： | 1 |
| 16 | Determination of the frequencies of restorer-and maintainer-alleles involved in CMS1 and CMS2 in German chive varieties显示文摘 | Engelke T Gera D Tatlioglu T | 2004 | Plant Breeding2004，123，1： | 1 |
| 17 | The phosphoenolpy-vate phosphor- transferase system in group A Streptococcus acts to reduce strep- tolysin S activity and lesion severity during soft tissue infection显示文摘 | Gera K Le T Jamin R | 2014 | Infect Immun2014，82，3： | 1 |
| 18 | Estima- tion of radioactive contamination of soils from the 'Balapan' and the experimental field' technical areas of the Semipalatinsk nuclear test site显示文摘 | Belykh E Evseeva T Geras'kin S | 2012 | J Environ Radioact2012，109，： | 1 |
| 19 | Assessment of soil degradation in areas of nuclear explosions at the Semipalatinsk nuclear test site显示文摘 | Evseeva T I Geras'kin S A Majstrenko T A | 2011 | Biophys2011，56，4： | 1 |
| 20 | Hydrodynamics of particle segregation in fluidized beds显示文摘 | Gera D Syamlal M O' Brien T J | 2004 | International Journal of Muhiphase Flow2004，30，41： | 1 |
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