| 1 | Efficacy of rituximab in gastric diffuse large B cell lymphoma patients显示文摘AIM:To evaluate retrospectively the efficacy of rituximab plus chemotherapy in gastric diffuse large B cell lymphoma(DLBCL).METHODS:Sixty patients(median age:58 years)with histologically confirmed gastric DLBCL treated at four Italian institutions between 2000 and 2007,were included in this analysis.Patients were selected by stage (Ⅰ-Ⅳ,Lugano staging system),European Cooperative Oncology Group performance status(0-2)and treatment strategies.Treatment strategies were chemotherapy alone(group A,n=30)[scheduled as cyclophosphamide,doxorubicin,vincristine and prednisone (CHOP)and CHOP-like],and chemotherapy combined with rituximab(group B,n=30).The primary end point of the study was complete response(CR)rate;the secondary end points were disease-free survival (DFS)at 5 years and overall survival(OS).RESULTS:Median follow-up was 62 mo(range:31102 mo).We observed a significant difference between the two groups(A vs B)in terms of CR[76.6%(23/30) vs 100%,P=0.04)and DFS at 5 years[73.3%(22/30) vs 100%,P=0.03).To date,19 group A(63.3%) patients are alive and 11 have died,while all group B patients are alive.No significant differences in toxicity were observed between the two groups.CONCLUSION:Rituximab in combination with chemotherapy improves CR rate,DFS and OS.Further prospective trials are needed to confirm our results. | Davide Leopardo Giuseppe Di Lorenzo Amalia De Renzo Piera Federico Serena Luponio Carlo Buonerba Elide Matano Gerardina Merola Martina Imbimbo Enzo Montesarchio Antonio Rea Maria Carmela Merola Sabino De Placido Giovannella Palmieri | 2010 | World Journal of Gastroenterology2010，16，20： | 19 |
| 5 | In situ grazing-incidence small-angle X-ray scattering observation of block-copolymer templated formation of magnetic nanodot arrays and their magnetic properties显示文摘bit-patterned 媒介(BPM ) 的制造为硬盘驱动器的新类型是关键的。为 BPM 的生产的方法的发展很快正在进行。常规平版印刷术活动范围关于侧面的分辨率的限制,和新线路被需要。在这研究,我们主要在蚀刻持续时间的 Ar +-ion 上集中于尺寸的依赖和磁性的 nanodots 的形状,用象面具的硅石点。二维(2D ) 磁性的 nanostructures 的数组作为模板用充满硅石的 diblock 共聚物微粒被创造。在以后进 2D 的微粒自己组装六角形的数组,聚合物壳被移开,并且 SiO 2 核心被利用把形态学转变成一(公司 / 磅) 经由离子在正常下面蚀刻的 2-multilayer 发生。准备步的数字被使尽可能低简化 nanostructure 数组的形成。在 situ 放牧发生高分辨率散布的小角度的 X 光检查(GISAXS ) 调查在蚀刻监视并且控制制造进程的 Ar +-ion 期间被执行。在里面 situ 调查提供蚀刻的条件怎么能为进一步的前 situ 实验被改进的信息。GISAXS 模式与模拟相比。我们观察到点在形状变化从对圆柱在蚀刻的过程期间圆锥形。磁性的行为被利用磁电机眼的克尔效果学习。公司 / 磅点展出取决于他们的尺寸, interparticle 距离,和蚀刻的时间的不同磁性的行为。他们与对这部电影垂直的磁化的容易的轴显示出强磁性。coercivity 的系统的依赖准时地,尺寸被观察。 | Andreas Meyer Norbert Franz Hans Peter Oepen Jan Perlich Gerardina Carbone Till Hartmut Metzger | 2017 | Nano Research2017，10，2： | 1 |
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