|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Turnover rate and kinetic mechanism for the reaction of hydrodechlorination of 1, 1-dichlorotertrafluoroethane(CF3-CFCl2) over a polycrystalling Pd foil显示文摘 | Riberio F H Gerken C A Somorjai G A | 1997 | Catal Lett1997，45，： | 1 |
| 3 | Interferon alfa for chronic hepatitis B infection:increased efficacy of prolonged treatment 显示文摘 | JANSSEN H L GERKEN G CARRENO V | 1999 | Hepatology1999，30，2： | 1 |
| 4 | Early HBeAg loss during peginterferon alpha-2b therapy predicts HBsAg loss: results of a long-term follow-up study in chronic hepatitis B patients 显示文摘 | Buster EH Flink I-IJ Simsek H Heathcote FA Sharmila S Kitis GE Gerken G Buti M de Vries RA Verhey E Hansen BE Janssen HL | 2009 | Am J Gastroenterol2009，104，10： | 1 |
| 5 | HBV viral load within subpopulation of peripheral blood mononuclear cells in HBV infection using limiting dilution PCR 显示文摘 | Trippler M Meyer Z B K H Gerken G | 1999 | J Virol Methods1999，78，12： | 1 |
| 6 | Laccase isolation by foam fractionation New prospects of an old process显示文摘 | Linke D Zorn H Gerken B | 2007 | Enzyme MicrobTechnol2007，40，4： | 1 |
| 7 | Genetics of photosensitive epilepsy显示文摘 | Doose H Gerken H Hein-Volpel KF | 1969 | Neuropaediatrie1969，1，： | 1 |
| 8 | Long-term management and prognosis of autoimmune hepatitis (AIH):a single center experience显示文摘 | Kanzler S L(o)hr H Gerken G | 2001 | Z Gastroenterol2001，39，5： | 1 |
| 9 | Genetic evidence for functional interactions between TolC and AcrA proteins of a major antibiotic efflux pump of Escherichia coli显示文摘 | Gerken H Misra R | 2004 | Mol Microbio12004，54，3： | 1 |
| 10 | MzrA-EnvZ interactions in the periplasm influence the EnvZ/OmpR two-component regulon显示文摘 | Gerken H Misra R | | 0，，23： | 1 |
| 11 | Molecularmechanisms for photosynthetic carbon partitioning intostorage neutral lipids in Nannochloropsis oceanica undernitrogen-depletion conditions显示文摘 | JIA J HAN D X GERKEN H G | 2015 | Algal research2015，7，： | 1 |
| 12 | Laccase isolation by foam fractionation-new prospects and an old process 显示文摘 | Linke D Zorn H Gerken B | 2007 | Enzyme and Microbioi Technology2007，40，4： | 1 |
| 13 | Genetic evidence for functional interactions between TolC and AcrA proteins of a major antibiotic efflux pump of Escherichia coli显示文摘 | GERKEN H MISRA R | 2004 | Mol Microbiol2004，54，3： | 1 |
| 14 | Turnover rate and kinetic mechanism for the reaction of hydrodechlorination of 1,1-dichlorotetrafluoroethane ( CF3 -CFC12 ) over a polycrystalline Pd foil 显示文摘 | Ribeiro F H Gerken C A Somorjai G A | 1997 | Catal Lett1997，45，34： | 1 |
| 15 | Structure insensitivity and effect of sulfur in the reaction of hydrodechlofination of 1,1 -dichlorotetrafluoroethane ( CF3 -CFC12 ) over Pd catalysts 显示文摘 | Ribeiro F H Gerken C A Rupprechter G | 1998 | J Catal1998，176，2： | 1 |
| 16 | Jointless bridges -the knowns and the unknowns显示文摘 | Russell H G Gerken L J | 1994 | Concrete International1994，，4： | 1 |
| 17 | centrencephalic myoclon ic - astatic petit mal Clinical and genetic investigations显示文摘 | Doose H Gerken H Leonhardt R | 1970 | Neuro- pediatrie1970，2，： | 1 |
| 18 | Bile duct epithelia as largetcells in primary biliary cirrhosis and primary selerosing cholangitis显示文摘 | Dienes H P Lohse A W Gerken G | 1997 | Virchows Arch1997，431，2： | 1 |
| 19 | Low frequency of cytotoxic liver-infiltrating T lymphocytes specific for endogenous processed surface and core proteins in chronic hepatitis B显示文摘 | Lohr H F Gerken G Schlicht H J | 1993 | J Infect Dis1993，168，5： | 1 |
| 20 | Centrencephalic myoclonic-astatic petit real显示文摘 | Doose H Gerken H Leonhardt R | 1970 | Neoropediatrie1970，2，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员