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| 1 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 2 | SOAR Telescope :4 meter high performance mount performance results显示文摘 | WARNER C M VICTOR K GERMAN S | 2004 | Proceeding of SPIE2004，5495，： | 1 |
| 3 | Kinetics of liquid sintering 显示文摘 | German RM Farooq S Kipphut C M | 1988 | Materials Science & Engineering A1988，88，105106： | 1 |
| 4 | Insights into subunit interactions within the insect olfactory receptor complex using fret 显示文摘 | German PF van der Poel S Carraher C | 2013 | Insect Biochem Mol Biol2013，43，2： | 1 |
| 5 | Where Are the Undiscovered Hydrothermal Vents on Oceanic Spreading Ridges? 显示文摘 | Beaulieu S E Baker E T German C R | 2015 | Deep Sea Research Part II: Topical Studies in Oceanography2015，121，： | 1 |
| 6 | The effect of contiguity on growth kinetics in liquid-phase sintering显示文摘 | YANG S C MANI S S GERMAN R M | 1990 | JOM1990，42，4： | 1 |
| 7 | Executive functioning,memory,and learning in phenylketonuria显示文摘 | Channon S German E Cassina C | 2004 | Neuropsychology2004，18，4： | 1 |
| 8 | SOAR telescope 4 meter high performance mount performance results 显示文摘 | Warner C M Victor K German S | 2004 | SPIE2004，5495，： | 1 |
| 9 | Gravity and configurational energy induced microstructural changes in liquid phase sintering 显示文摘 | Kipphut C M Bose A Farooq S German R M | 1988 | Metallurgical Transactions A1988，19，： | 1 |
| 10 | Com distillers dried grains with sohibles in growing-finishing swine rations显示文摘 | Wahlstrom R C German C S Libal G W | 1970 | J Anita Sci1970，30，： | 1 |
| 11 | Executive functioning,memory,and learning in phenylketonuria显示文摘 | Channon S German E Cassina C Lee P | 2004 | Neuropsychology2004，18，4： | 1 |
| 12 | Kinetics of Liquid Sintering显示文摘 | German R M Farooq S Kipphut C M | 1988 | Materials Science and Engineering1988，，1： | 1 |
| 13 | Expression and cell localization of brain-derived neurotrophic factor and TrkB during zebrafish retinal development显示文摘 | Germanà A Sánchez-Ramos C Guerrera MC Calavia MG Navarro M Zichichi R | | 0，，3： | 1 |
| 14 | Risks of re-straints in head injury显示文摘 | Burton L. C German P. S Rovner B. W | | 0，，： | 1 |
| 15 | Distributions of dissolved manganese and fluorescent dissolved organic matter in the Columbia River estuary and plume as determined by in situ measurement 显示文摘 | Klinkhammer G P Chin C S Wilson C Rudnicki M D German C R | 1997 | Mar Chem1997，56，12： | 1 |
| 16 | Multidrug-and ex tensively drug-resistant tuberculosis, Germany显示文摘 | Eker B Ortmann j Migliori GB Sotgiu G Mueuerlein R Centis R Hoffmann H Kirslen D Schaberg T Ruesch-Gerdes S Lange C German TBNET Group | 2008 | Emerg In fect Dis2008，14，11： | 1 |
| 17 | Same day diagnostic service for new cases of heamaturia-a district general hospital experience显示文摘 | Hasan S T German K Derry C D | 1994 | Br J Urol1994，73，： | 1 |
| 18 | Development of new W-Ni-Mn heavy alloy显示文摘 | Bose A Yang S C German R M | 1991 | Advanced in Powder Metallurgy1991，6，6： | 1 |
| 19 | Hydrothermal plume particle fluxes at 13°N on the East Pacific Rise显示文摘 | German C R Colley S Palmer M R | 2002 | Deep Sea Research I2002，49，： | 1 |
| 20 | Effectof retinoic acid on glucokinase activity and gene expression and insulinsecretion in primary culture of pancreatic islets显示文摘 | Valladares G C German M S Matschinsky F M | 1999 | Endocrinology1999，140，： | 1 |
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