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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy显示文摘 | Koc 0 N Gerson S L Cooper B W | 2000 | J Clin Oncol2000，18，2： | 1 |
| 3 | Optimization of storage conditions for cocaine and benzoylecgonine in urine: a review显示文摘 | Hippenstiel M J Gerson B | 1994 | J Anal Toxicol1994，18，2： | 1 |
| 4 | Suicide risk in placebo-controlled studies of major depression显示文摘 | Storosum JG van Zwieten B J van den Brink W Gersons BPR Broekman AW | 2001 | Am J Psychiatry2001，158，： | 1 |
| 5 | Guidelines for the di- agnosis and management of gastroesophageal reflux dis- ease 显示文摘 | Katz P O Gerson L B Vela M F | 2013 | Am J Gastroenterol2013，108，3： | 1 |
| 6 | Chemical colitis显示文摘 | SHEIBANI S GERSON L B | 2008 | J Clin Gastroenterol2008，42，2： | 1 |
| 7 | Guidelines for the diagnosis and management of gastroesophageal re- flux disease显示文摘 | KATZ P O GERSON L B VELA M F | 2013 | Am J Gastroenterol2013，108，： | 1 |
| 8 | The role of copper,molybdenum,selenium in nutrition health显示文摘 | Can S Gerson B Subramaniam S | 1998 | Clin Lab Med1998，18，4： | 1 |
| 9 | Genetic variation of piper- idine alkaloids in Pinus ponderosa: a common garden study 显示文摘 | Gerson E A Kelsey R G St Clair J B | 2009 | Annals of Botany2009，3，103： | 1 |
| 10 | Mechanical properties and morphology of NBR with different clays 显示文摘 | De Sousa Fabiula D B Mantovani Gerson L Seuracchio Carlos H | 2011 | Polymer Testing2011，30，8： | 1 |
| 11 | CD133+ cells contribute to radioresistance via altered regulation of DNA repair genes in human lung cancer cells 显示文摘 | Desai A Webb B Gerson SL | 2014 | Radiother Oncol2014，110，3： | 1 |
| 12 | The role of copper, molybdenum,selenium in nutrition health显示文摘 | Can S Gerson B Subramaniam S | 1998 | Clin Lab Med1998，18，4： | 1 |
| 13 | Cyclosporine显示文摘 | Gerson B | 1985 | Clin Immunoassay1985，8，3： | 1 |
| 14 | A mixed integer disjunctive model for transmission network expansion显示文摘 | Laura B Gerson C O Mario P | 2001 | IEEE Transactions on Power Systems2001，16，3： | 1 |
| 15 | Rapid hematopoietie recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy 显示文摘 | Koc O N Gerson S L Cooper B W | 2000 | J Clin Oncol2000，18，： | 1 |
| 16 | Galvanic corrosion of laser weldments of AA6061 aluminium alloy显示文摘 | Mujibur Rahman A B M Kumar S Gerson A R | 2007 | Corrosion Science2007，49，12： | 1 |
| 17 | The influence of occupational debriefing on post-traumatic stress symptomatology in traumatized police officers显示文摘 | Carlier I V Voerman A E Gersons B P | 2000 | Br J Med Psychol2000，73，1： | 1 |
| 18 | Adult bone marrow stem cell for cells and gene therapies: implications for greater use显示文摘 | Ballas C B Zielske S P Gerson S L | 2002 | J Cell Biochem Suppl2002，38，： | 1 |
| 19 | A greedy randomized adaptive search procedure for transmission expansion planning显示文摘 | Silvio B Gerson C de O Joao L de A | 2001 | IEEE Transaction on Power Systems2001，16，2： | 1 |
| 20 | Rapid hematopoietic recovery after eoinfusion of autologous- blood stem cells and cultureexpanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy显示文摘 | Koc O Gerson S Cooper B | 2000 | J Clin Oncol2000，18，： | 1 |
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