|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Muscle force and fatigue in patients with sepsis and multiorgan failure显示文摘 | Eikermaim M Koch G Gerwig M | 2006 | Care Med2006，32，2： | 1 |
| 2 | Vitamin D receptor initiation codon polymorphism, bone density and inflammatory activity of patients with ankyiosing spnndylitis显示文摘 | Barbara M Uwe L Gerwig F | 2003 | Osteoporos Int2003，14，12： | 1 |
| 3 | Muscleforce and fatigue in patients with sepsis and multiorganfailure显示文摘 | EIKERMANN M KOCH G GERWIG M | 2006 | Intensive Care Med2006，32，2： | 1 |
| 4 | Structural basis for ligand and substrate recognition by torovirus hemagglutinin esterases显示文摘 | LANGEREIS M A ZENG Q GERWIG GJ | 2009 | Proc Natl Acad Sci USA2009，106，15： | 1 |
| 5 | Cognitive functions in pa- tients with MR-defined chronic focal cerebellar lesions 显示文摘 | Richter S Gerwig M Asian B | 2007 | Journal of neurology2007，254，： | 1 |
| 6 | Amplitude changes of unconditioned eyeblink responses in patients with cerebellar lesions显示文摘 | Gerwig M Dimitrova A Maschke M | 2004 | Exp Brain Res2004，155，3： | 1 |
| 7 | The IBM eServer z990 Floating-Point Unit显示文摘 | Gerwig G Wetter H Schwarz E M | 2004 | IBM Journal of Research and Development2004，48，34： | 1 |
| 8 | Eyeblink conditioning in patients with hereditary ataxia:a one-year follow-up study显示文摘 | Timmann D Gerwig M Frings M | 2005 | Exp Brain Res2005，162，： | 1 |
| 9 | The IBM Eserver z990 Floating-point Unit 显示文摘 | Gerwig G Wetter H Schwarz E M | 2004 | IBM Journal of Research and Development2004，48，34： | 1 |
| 10 | Elevated levels of high-sensitivity C-reactive protein are associated with mild cognitive impairment and its subtypes: results of a population-based case-control study显示文摘 | Dlugaj M Gerwig M Wege N | 2012 | J Alzheimers Dis2012，28，3： | 1 |
| 11 | Muscle force and fatiguein patients with sepsis and multiorgan failure显示文摘 | Eikermann M Koch G’Gerwig M | 2006 | Intensive CareMed2006，32，： | 1 |
| 12 | Adult post-infectious thalamic encephalitis: acute onset and benign course显示文摘 | Gerwig M Kastrup O Wanke I | 2004 | European J Neurol2004，11，： | 1 |
| 13 | Posterior reversible encephalopathy syndrome (PRES):electroencephalographic findings and seizure patterns显示文摘 | Kastrup O Gerwig M Frings M | | 0，，07： | 1 |
| 14 | Pallidal deep brainstimulation relieves camptocormia in primary dystonia显示文摘 | Hagenacker T Gerwig M Gasser T | 2013 | J Neurol2013，260，： | 1 |
| 15 | Muscle force and fatigue in patients with sepsis and muhiorgan failure 显示文摘 | Eikermann M Koch G Gerwig M | 2006 | Intensive Care Med2006，32，2： | 1 |
| 16 | Learning of Sensory Sequences in Cerebellar Patients 显示文摘 | Frings M Raoul Boenisch Marcus Gerwig | 2004 | Learning and Memory2004，11，3： | 1 |
| 17 | Hepatocyte cytoskeleton during ischemia and reperfusion -influence of ANP-mediated p38 MAPK activation显示文摘AIM: To determine functional consequences of this activation, whereby we focused on a potential regulation of the hepatocyte cytoskeleton during ischemia and reperfusion.METHODS: For in vivo experiments, animals received ANP (5 μg/kg) intravenously. In a different experimental setting, isolated rat livers were perfused with KH-buffer ±ANP (200 nmol/L)±SB203580 (2 μmol/L). Liverswere then kept under ischemic conditions for 24 h, and either transplanted or reperfused. Actin, Hsp27, and phosphorylated Hsp27 were determined by Western blotting, p38 MAPK activity by in vitro phosphorylation assay. F-actin distribution was determined by confocal microscopy.RESULTS: We first confirmed that ANP preconditioning leads to an activation of p38 MAPK and observedalterations of the cytoskeleton in hepatocytes of ANPpreconditioned organs. ANP induced an increase of hepatic F-actin after ischemia, which could be prevented by the p38 MAPK inhibitor SB203580 but had no effect on bile flow. After ischemia untreated livers showed a translocation of Hsp27 towards the cytoskeleton and an increase in total Hsp27, whereas ANP preconditioning prohibited translocation but caused an augmentation of Hsp27 phosphorylation. This effect is also mediated via p38 MAPK, since it was abrogated by the p38 MAPK inhibitor SB203580.CONCLUSION: This study reveals that ANP-mediated p38 MAPK activation leads to changes in hepatocyte cytoskeleton involving an elevation of phosphorylated Hsp27 and thereby for the first time shows functional consequences of ANP-induced hepatic p38 MAPK activation. | Melanie Keller Alexander L Gerbes Stefanie Kulhanek-Heinze Tobias Gerwig Uwe Grützner Nico van Rooijen Angelika M Vollmar Alexandra K Kiemer | 2005 | World Journal of Gastroenterology2005，11，47： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员