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| 1 | New findings showing how DNA methylation influences diseases显示文摘In 1975, Holliday and Pugh as well as Riggs independently hypothesized that DNA methylation in eukaryotes could act as a hereditary regulation mechanism that influences gene expression and cell differentiation. Interest in the study of epigenetic processes has been inspired by their reversibility as well as their potentially preventable or treatable consequences. Recently, we have begun to understand that the features of DNA methylation are not the same for all cells.Major differences have been found between differentiated cells and stem cells.Methylation influences various pathologies, and it is very important to improve the understanding of the pathogenic mechanisms. Epigenetic modifications may take place throughout life and have been related to cancer, brain aging, memory disturbances, changes in synaptic plasticity, and neurodegenerative diseases,such as Parkinson's disease and Huntington's disease. DNA methylation also has a very important role in tumor biology. Many oncogenes are activated by mutations in carcinogenesis. However, many genes with tumor-suppressor functions are 'silenced' by the methylation of CpG sites in some of their regions.Moreover, the role of epigenetic alterations has been demonstrated in neurological diseases. In neuronal precursors, many genes associated with development and differentiation are silenced by CpG methylation. In addition,recent studies show that DNA methylation can also influence diseases that do not appear to be related to the environment, such as IgA nephropathy, thus affecting,the expression of some genes involved in the T-cell receptor signaling. In conclusion, DNA methylation provides a whole series of fundamental information for the cell to regulate gene expression, including how and when the genes are read, and it does not depend on the DNA sequence. | Fabio Sallustio Loreto Gesualdo Anna Gallone | 2019 | World Journal of Biological Chemistry2019，10，1： | 2 |
| 2 | Dialysate and replacement fluid composition for CRRT显示文摘 | AUCELLA F DI PAOLO S GESUALDO L | 2007 | Contrib Neph- rol2007，156，： | 1 |
| 3 | MCP-1 and EGF renal expression and urine excretion in human congenital obstructive nephropathy显示文摘 | Grandaliano G Gesualdo L Bartoli F | | 0，，： | 1 |
| 4 | Postconditioning is an effective strategy to reduce renal ischemia /reperfusion injury 显示文摘 | Serviddio G Romano AD Gesualdo L | 2008 | Nephrol Dial Transplant2008，23，5： | 1 |
| 5 | The Italian experi- ence of the national registry of renal biopsies显示文摘 | Gesualdo L Di PAM Morrone LF | 2004 | Kidney Int2004，66，3： | 1 |
| 6 | Pathogenetic mechanisms of diabetic nephropathy显示文摘 | Schena FP Gesualdo L | | 0，，1： | 1 |
| 7 | Prospective randomized controlled multicenter trial on steroids plus ramipril in proteinuric IgA nephropathy显示文摘 | MANNO C GESUALDO L d' ALTRI C | 2001 | J Nephrol2001，14，4： | 1 |
| 8 | Non- linear positional formulation for space truss analysis 显示文摘 | Greco M Gesualdo F A R Venturini W S | 2006 | Finite Elements in Analysis and Design2006，42，： | 1 |
| 9 | A pathophysiological view of the long non - coding RNA world显示文摘 | Di Gesualdo F Capaceioli S Lulli M | 2014 | Oneotarget2014，5，10： | 1 |
| 10 | Update on pregnancy in chronic kidney disease显示文摘 | Castellano G Losappio V Gesualdo L | | 0，，04： | 1 |
| 11 | A novel cardiac bio- marker: ST2: a review显示文摘 | Ciccone MM Cortese F Gesualdo M | 2013 | Molecules2013，18，15： | 1 |
| 12 | High glucuse concentration induces the overexpression of transfotruing growth factor-beta through the activation of platelet-derived growth factor loop in human mesangial cells 显示文摘 | Di Paolo S Gesualdo L Ranieri E | 1996 | Am J Pathology1996，149，6： | 1 |
| 13 | Pathogenetic mechanisms of diabetic nephropathy 显示文摘 | Schena FP Gesualdo L | 2005 | JAM Soc Nephrol2005，16，11： | 1 |
| 14 | Postcondi- tioning is an effective strategy to reduce renal ischaemia/ reperfusion injury 显示文摘 | Serviddio G Romano A D Gesualdo L | 2008 | Nephrol Dial Transplant2008，23，5： | 1 |
| 15 | Epidemiology of primary glomerulonephritis in the elderly:Report from the Italian Registry of Renal Biopsy 显示文摘 | Vendemia F Gesualdo L Schena FP et Al | 2001 | J Nephrol2001，14，5： | 1 |
| 16 | Isolation and characterization of four type-1 ribosome-inactivating proteins, with polynucleotide:adenosine glycosidase activity, from leaves of Phytolacca dioica L.显示文摘 | Antimo Di Maro Paola Valbonesi Andrea Bolognesi Fiorenzo Stirpe Paolo De Luca Gesualdo Siniscalco Gigliano Luciano Gaudio Pasquale Delli Bovi Pasquale Ferranti Antonio Malorni Augusto Parente | 1999 | Planta1999，，1： | 1 |
| 17 | A pathophysiological viewof the long non-coding RNA world 显示文摘 | Di Gesualdo F Capaeeioli S Lulli M | 2014 | Oncotarget2014，5，10： | 1 |
| 18 | A pathophysiological view of the long non-coding RNA world显示文摘 | Di Gesualdo F Capaccioli S Lulli M | 2014 | Oncotarget2014，5，10： | 1 |
| 19 | Monocyte chemotactic peptide-1 expression in acute and chronic human nephritides: a pathogenetic role in interstitial monocytes recruitment 显示文摘 | Grandaliano G Gesualdo L Ranieri E | 1996 | J Am Soc Nephrol1996，7，： | 1 |
| 20 | A Novel Cardiac Bio-Marker:ST2:A review显示文摘 | Ciccone MM Cortese F Gesualdo M | 2013 | Molecules2013，18，15： | 1 |
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