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| 1 | Rubber band ligation for 750 cases of symptomatic hemorrhoids out of 2200 cases显示文摘AIM: To study the results for the treatment of symptomatic hemorrhoids using rubber band ligation (RBL) method. METHODS: A retrospective study for 750 patients who came to the colorectal unit from June, 1998 to September, 2006, data was retrieved from archived fi les. RBL was performed using the Mc Gown applicator on an outpatient basis. The patients were asked to return to out-patient clinic for follow up at 2 wk, 1 mo, 6 mo and through telephone call every 6 mo for 2 years). RESULTS: After RBL, 696 patients (92.8%) were cured with no difference in outcome for second or third degree hemorrhoids (P = 0.31). Symptomatic recurrence was detected in 11.04% after 2 years. A total of 52 patients (6.93%) had 77 complications from RBL which required no hospitalization. Complications were pain, rectal bleeding and vaso-vagal symptoms(4.13%, 4.13% and 1.33% of patients, respectively). At 1 mo there were a significant improvement in mean SF-36 scores over baseline in five items, while after 2 years there were improvement in all items over baseline, but not significant. No significant manometeric changes after band ligation. CONCLUSION: RBL is a simple, safe and effective method for treating symptomatic second and third degree hemorrhoids as an out patient procedure with signifi cant improvement in quality of life. RBL doesn't alter ano-rectal functions. | Ayman M El Nakeeb Amir A Fikry Waleed H Omar Elyamani M Fouda Tito A El Metwally Hosam E Ghazy Sabry A Badr Mohmed Y Abu Elkhar Salih M Elawady Hisham H Abd Elmoniam Waiel W Khafagy Mosaad M Morshed Ramadan E El Lithy Mohamed E Farid | 2008 | World Journal of Gastroenterology2008，14，42： | 24 |
| 2 | Potential mechanisms of hepatitis B virus induced liver injury显示文摘Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma.The histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers.The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components.The viral and cellular factors that contribute to liver injury are discussed in this article.Liver injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and maintenance.The consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of nutrients.The identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury. | Mohd Suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，35： | 12 |
| 3 | Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells显示文摘AIM: To explore the approaches exerted by mesenchymal stem cells(MSCs) to improve Parkinson's disease(PD) pathophysiology.METHODS: MSCs were harvested from bone marrowof femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group(1) was control, Groups(2) and(3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group(2) was left untreated, while Group(3) was treated with single intravenous dose of bone marrow derived MSCs(BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1(TGF-β1), monocyte chemoattractant protein-1(MCP-1) and brain derived neurotrophic factor(BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase(TH) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. Histopathological investigation of brain tissues was also done.RESULTS: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1(489.7 ± 13.0 vs 691.2 ± 8.0, P < 0.05) and MCP-1(89.6 ± 2.0 vs 112.1 ± 1.9, P < 0.05) levels associated with significant increase in serum BDNF(3663 ± 17.8 vs 2905 ± 72.9, P < 0.05) and brain DA(874 ± 15.0 vs 599 ± 9.8, P < 0.05) levels as well as brain TH(1.18 ± 0.004 vs 0.54 ± 0.009, P < 0.05) and nestin(1.29 ± 0.005 vs 0.67 ± 0.006, P < 0.05) genes expression levels. In addition to, producing insignificant increase in the number of positive cells for survivin(293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histological structure of the striatum as a result of treatment with BM-MSCs. CONCLUSION: The current study sheds light on the therapeutic potential of BM-MSCs against PD pathophysiology via multi-mechanistic actions. | Hanaa H Ahmed Ahmed M Salem Hazem M Atta Emad F Eskandar Abdel Razik H Farrag Mohamed A Ghazy Neveen A Salem Hadeer A Aglan | 2016 | World Journal of Stem Cells2016，8，3： | 9 |
| 4 | Xanthanolides from Xanthium spinosum 显示文摘 | Omar A A Elrashidy E M Ghazy N A | 1984 | Phytochemistry1984，23，4： | 1 |
| 5 | Monolithic high-speed CMOS-photoreceiver显示文摘 | H Zimmermann T Heide A Ghazi | 1999 | IEEE Photonics Technology Letters1999，11，2： | 1 |
| 6 | 显示文摘 | Shan A Y Ghazi T I M Rashid S A | 2010 | Appl Catal a Gen2010，389，12： | 1 |
| 7 | Kinetic study of jatropha biolubricant from transesterification of jatropha curcas oil with trimethylolpropane: Effects of temperature显示文摘 | Gunam Resul M F M Mohd Ghazi T I Idris A | 2012 | Industrial Crops andProduets2012，38，： | 1 |
| 8 | Numerical Simula tion of the Influence of Fabric's Motion on Protective Clothing Performance During Flash Fire Exposure 显示文摘 | GHAZY A BERGSTROM D J | 2013 | Heat and Mass Transfer2013，49，6： | 1 |
| 9 | Risk factors ofosteoporosis in healthy Moroccan men 显示文摘 | El Maghraoui A Ghazi M Gassim S | 2010 | BMC MusculoskeletDisord2010，，148： | 1 |
| 10 | Drought stress and VA mycorrhizal fungi effects on growth and nutrient up take of two wheat genotypes differing in drought resistance 显示文摘 | AL-Karaki Ghazi N AL-Raddad A | 1997 | Crop Research(Hisar)1997，13，2： | 1 |
| 11 | The effect of silicone gel bleed on capsular contracture:a generational study显示文摘 | Moyer HR Ghazi BH Losken A | | 0，，4： | 1 |
| 12 | Knock in spark ignition hydrogen engines显示文摘 | Hailin L Ghazi A K | 2004 | International Journal of Hydrogen Energy2004，29，8： | 1 |
| 13 | Determination of rare earth elements in fluid inclusions by inductive coupled plasma-mass spectrometry显示文摘 | Ghazi A M Vanko D A Roedder E | 1993 | Geochem Cosmochim Acta1993，57，： | 1 |
| 14 | Indirect spectrometric determination of small amounts of selenium (%) and arsenic (&) by simple extraction using flotation columns显示文摘 | Mostafa G A Ghazy S E | 2001 | Anal Sci2001，17，： | 1 |
| 15 | A question of clinical reliability:observed versus EuroSCORE-predicted mortality after aortic valve replacement显示文摘 | Ghazy T Kappert U Ouda A | | 0，，1： | 1 |
| 16 | Design and implementation of a wearable healthcare monitoring system显示文摘 | Sagahyroon A Raddy H Ghazy A | 2009 | Int J Electron Healthe2009，5，1： | 1 |
| 17 | Immobilisation of titanium dioxide onto supporting materials in heterogeneous photocatalysis:a review显示文摘 | Shan A Y Ghazi T I M Rashid S A | 2010 | Applied Catalysis A:General2010，389，1： | 1 |
| 18 | Maternal morbidity in e-mergency versus elective caesarean section at a tertiary care hospi-tal显示文摘 | Ghazi A Karim F Hussain AM | 2012 | J Ayub Med Coll Abbottabad2012，24，1： | 1 |
| 19 | Diabetic thermal hyperalgesia: role of TRPV1 and CB1 receptors of periaqueduetal gray 显示文摘 | Mohammadi-Farani A Sahebgbarani M Sepehrizadeh Z Jaberi E Ghazi Khansari M | 2010 | Brain Res2010，1328，： | 1 |
| 20 | CLIVAR/GCOS/WMO workshop on indices and indicators for climate extremes:workshop summary显示文摘 | KARL T R NICHOLLS N GHAZI A | 1999 | Climatic Change1999，42，： | 1 |
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