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| 1 | Idarubicin vs doxorubicin in transarterial chemoembolization of intermediate stage hepatocellular carcinoma显示文摘BACKGROUND Liver cancer is the fifth most common cancer and the second cause of cancerrelated deaths worldwide.Transarterial chemoembolization(TACE)is the best treatment of intermediate hepatocellular carcinoma(HCC).Doxorubicin is the most commonly used drug despite a low level of evidence.AIM To compare the objective response rate of idarubicin-based TACE(Ida-TACE)against doxorubicin-based TACE(Dox-TACE)in intermediate stage HCC.METHODS Between January 2012 and December 2014,all patients treated with TACE at our academic hospital were screened.Inclusion criteria were patients with Child-Pugh score A or B,a performance status below or equal to 1,and no prior TACE.Either lipiodol TACE or drug-eluting beads TACE could be performed with 10 mg of idarubicin or 50 mg of doxorubicin.Each patient treated with idarubicin was matched with two doxorubicin-treated patients.The TACE response was assessed by independent radiologists according to the mRECIST criteria.RESULTS Sixty patients were treated with doxorubicin and thirty with idarubicin.There were 93%and 87%of cirrhotic patients and 87%and 70%of Child-Pugh A in the doxorubicin and idarubicin groups,respectively.The median number of HCC per patient was two in both groups with 31%and 26%of single nodules in doxorubicin and idarubicin groups,respectively.Objective response rate after first TACE was 76.7%and 73.3%(P=0.797)with 41.7%and 40.0%complete response in doxorubicin and idarubicin groups,respectively.Progression-free survival was 7.7 mo in both groups,and liver transplant-free survival was 24.9 mo and 21.9 mo in doxorubicin and idarubicin groups,respectively.Safety profiles were similar in both groups,with grade 3-4 adverse events in 35%of Dox-TACE and 43%of Ida-TACEs.CONCLUSION Ida-TACE and Dox-TACE showed comparable results in terms of efficacy and safety.Ida-TACE may represent an interesting alternative to Dox-TACE in the management of patients with intermediate stage HCC. | Gael Stephane Roth Yann Teyssier Melodie Abousalihac Arnaud Seigneurin Julien Ghelfi Christian Sengel Thomas Decaens | 2020 | World Journal of Gastroenterology2020，26，3： | 3 |
| 2 | All-optical regeneration and demultiplexing for 160-gb/s transmission systems using a NOLM-hased three-stage scheme显示文摘 | BOGONI A GHELFI P SCAFFARDI M | 2004 | IEEE Journal of Selected Topics in Quantum Electronics2004，10，1： | 1 |
| 3 | Value Sharing and Food System Dynamics for Milk,Tomato and Cereals Food Chains显示文摘 | Aldo Bertazzoli Rino Ghelfi Sergio Rivaroli | | 0，，04： | 1 |
| 4 | Sus- tained exposure to the DNA demethylating agent, 2' -deoxy -S-azacytidine, leads to apoptotic cell death in chronic my- el, old leukemia by promting differentiation, senescence, and autophagy显示文摘 | Schnekenburger M Grandjenette C Ghelfi J | 2011 | Biochem Pharmacol2011，81，3： | 1 |
| 5 | PM-induced cardiac oxidative stress and dysfunction are mediated by autonomic stimulation显示文摘 | Rhoden CR Wellenius GA Ghelfi E Lawrence J GonzálezFlecha B | 2005 | Biochim Biophys Acta2005，1725，： | 1 |
| 6 | Comparisons of C-reactive protein and white biood cell count with differential in neonates at risk for septicaemia显示文摘 | Berger C Uehlinger J Ghelfi D | | 0，，02： | 1 |
| 7 | Photonie gen eration and independent steering of multiple RF sig nals for software defined radars显示文摘 | Ghelfi P Laghezza F Scotti F | 2013 | Optics Express2013，21，22： | 1 |
| 8 | Comparison of c-reactiveprotein and white blood cell cotnt with differential in neonates atrisk for septicaemia显示文摘 | Berger C Uehlinger J Ghelfi D | 1995 | Eur J Pediatr1995，154，2： | 1 |
| 9 | Endothelial cell-fatty acid binding protein 4 promotes angiogenesis : role of stem cell factor/c- kit pathway 显示文摘 | Elmasri H Ghelfi E Yu CW | 2012 | Angiogenesis2012，15，3： | 1 |
| 10 | Fatty acid binding pro- tein 4 is expressed in distinct endothelial and non-endothelial cell populations in glioblastoma 显示文摘 | Catahepe O Arikan MC Ghelfi E | 2012 | Neuropathol Appl Neurobiol2012，38，5： | 1 |
| 11 | Comparison of C-reactive protein and white blood cell count with differential in neonates at risk for septicaemia显示文摘 | BERGER C UEHLINGER J GHELFI D | 1995 | Eur J Pediatr1995，154，2： | 1 |
| 12 | PM-induced cardiac oxidative stress and dysfunction are mediated by autonomic stimulation 显示文摘 | RHODEN C R WELLENNIUS G A GHELFI E | 2005 | Biochim Biophys Acta2005，1725，3： | 1 |
| 13 | Photonic generationof phase-modulated RF signals for pulse compressiontechViiques in coherent radars 显示文摘 | Ghelfi P Scotti F Laghezza F | 2012 | Journal of LightwaveTechnology2012，30，11： | 1 |
| 14 | Cardiac oxidative stress and dysfunction by fine concentrated ambient particles (CAPs) are mediated by angiotensin -II 显示文摘 | Ghelfi E Wellenius GA Lawrence J | 2010 | Inhal Toxicol2010，22，11： | 1 |
| 15 | PM- induced areciac oxidative stress and dysfunction are mediated by autonomic stimulation显示文摘 | RHODEN C R WELLENIUS G A GHELFI E | 2005 | Biochim Biophys Acta2005，1725，3： | 1 |
| 16 | Cardiac oxidative stress and electrophysiological changesin rats exposed to concentrated ambient particles aremediated by TRP-dependent pulmonary reflexes显示文摘 | GHELFI E RHODEN C R WELLENIUS G A | 2008 | Toxicol Sci2008，102，2： | 1 |
| 17 | Comparisonof C-reactive protein and white blood cell count with differential inneonates at risk for septicaemia显示文摘 | Berger C Uehlinger J Ghelfi D Blau N Fanconi S | 1995 | Eur J Pediatr1995，154，2： | 1 |
| 18 | Fatty Acid Binding Protein 4 Deficiency Protects against Oxygen-Induced Retinopathy in Mice显示文摘 | Saint-Geniez M Ghelfi E Liang X L | 2014 | PLo S ONE2014，9，96： | 1 |
| 19 | Photonic ge- neration of phase-modulated RF signals for pulse com- pression techniques in coherent radars显示文摘 | GHELFI P SCOTTI F LAGHEZZA F | 2012 | Journal of Light- wave Technology2012，30，11： | 1 |
| 20 | Probiotic properties of Lactobacillus rhamnosus and Lactobacillus paracasei isolated from human faeces 显示文摘 | Verdenelli M C Ghelfi F Silvi S | 2009 | European Journal of Nutri- tion2009，48，6： | 1 |
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