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| 1 | Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C显示文摘AIM:To evaluate serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C virus(HCV)infection.METHODS:The study included 30 children with chronic HCV infection before receiving antiviral therapy.Chronic HCV infection was defined by positive anti-HCV,a positive polymerase chain reaction for HCV-RNA for more than 6 mo with absence of any associated liver disease.A second group of 30 age-and sex-matched healthy children served as controls.Serum C4a levels were measured by enzyme-linked immunosorbent assay.Liver fibrosis stage and inflammatory grade were assessed using Ishak scoring system.Serum C4a levels were compared according to different clinical,laboratory and histopathological parameters.Statistical significance for quantitative data was tested by MannWhitney U non-parametric tests.For qualitative data,significance between groups was tested by 2test.Correlation was tested by Spearman’s test.Results were considered significant if P value≤0.05.RESULTS:The age of the patients ranged from 3.5to 18 years and that of controls ranged from 4 to 17years.C4a mean levels were merely lower in patients(153.67±18.69 mg/L)than that in the controls(157.25±11.40 mg/L)with no statistical significance(P=0.378).It did not differ significantly in patients with elevated vs those with normal transaminases(152.25±16.62 vs 155.36±21.33;P=0.868)or with different HCV viremia(P=0.561).Furthermore,there was no statistical significant difference in serum levels between those with no/mild fibrosis and those with moderate fibrosis(154.65±20.59 vs 152.97±17.72;P=0.786)or minimal and mild activity(155.1±21.93 vs 152.99±17.43;P=0.809).Though statistically not significant,C4a was highest in fibrosis score 0(F0),decreasing in F1 and F2 to be the lowest in F3.When comparing significant fibrosis(Ishak score≥3)vs other stages,C4a was significantly lower in F3 compared to other fibrosis scores(143.55±2.33 mg/L vs 155.26±19.64 mg/L;P=0.047)and at a cutoff value of less than 144.01 mg/L,C4a could discriminate F3 with 76.9%sensitivity and75%specificity from other stages of fibrosis.CONCLUSION:Serum complement C4a did not correlate with any of transaminases,HCV viremia or with the histopathological scores.Although C4a decreased with higher stages of fibrosis,this change was not significant enough to predict individual stages of fibrosis.Yet,it could predict significant fibrosis with acceptable clinical performance. | Behairy E Behairy Ghada M El-Mashad Ragab S Abd-Elghany Enas M Ghoneim Mostafa M Sira | 2013 | World Journal of Hepatology2013，5，8： | 4 |
| 2 | Obstructive jaundice promotes intestinal-barrier dysfunction and bacterial translocation : experimental study 显示文摘 | Abdeldayem H Ghoneim E Refaei AA | 2007 | Hepatol Int2007，1，4： | 1 |
| 3 | Tuberculosis in Egyptian kidney trasplant recipients:study of clinical couse and outcome显示文摘 | el-Agroudy A E Refaie A F Moussa O M Ghoneim -M-A | 2003 | J Nephrol2003，16，3： | 1 |
| 4 | Delineation of paleolakes in the Sinai Peninsula, Egyt, using remote sensing and GIS显示文摘 | Gaber A Ghoneim E Khalaf F | 2008 | Arid Environments2008，73，2009： | 1 |
| 5 | Voltammetry and determination of metronidazole at a carbon fiber microdisk electrode 显示文摘 | Bartletta P N Ghoneim E EI-Hefnawy G | 2005 | Talanta2005，66，4： | 1 |
| 6 | Extracorporeal shock wave lithotripsy in impacted upper ureteral stones: a prospective randomized com- parison between stented and non-stented techniques 显示文摘 | Ghoneim I A EI-Ghoneimy M N E1-Naggar A E | 2010 | Urology2010，75，1： | 1 |
| 7 | Voltammetric and potentiometric studies of some sulpha drug-Schiff base compounds and their metal complexes显示文摘 | GHONEIM M M MABROUK E M HASSANEIN A M | 2007 | Central European Journal of Chemistry2007，5，3： | 1 |
| 8 | Simultaneous determination of Mn ( lI ), Cu ( I1 ) and Fe ( 111 ) as 2-(5'-bromo-2'-pyridylazo)-5-diethylaminophenol complexes by adsorptive cathodic stripping vohammetry at a carbon paste electrode 显示文摘 | Ghoneim E M | 2010 | Talanta2010，82，2： | 1 |
| 9 | Plasma soluble fibrin monomer complex is a useful predictor of disseminated intravascular coagulation in neonatal sepsis显示文摘 | SeIim T E Ghoneim H R Khashaba M T Rakha S A | 2005 | Haematologica2005，90，： | 1 |
| 10 | Adsorptive stripping voltammetrie quantification of the antipsyehotie drug elozapine in bulk form, pharmaceutical formulation and human serum at a mercury electrode 显示文摘 | Hammam E Tawfik A Ghoneim M M | 2004 | J Pharm Biomed Anal2004，36，1： | 1 |
| 11 | Characteristics and productivity of a sandy soil as influenced by soil conditioners in Saudi显示文摘 | SABRAH R E A GHONEIM M F EL-MAGID H M | 1993 | Abrbia J Arid Envron1993，，24： | 1 |
| 12 | Evolution of highly active enzymes by homology-independent recombination 显示文摘 | Griswold K E Kawarasaki Y Ghoneim N | 2005 | Proceedings of the National Academy of Sciences of the United States of America2005，102，10： | 1 |
| 13 | Speed of recovery and side-effect profile of sevoflurane sedation compared with midazolam 显示文摘 | IBRAHIM A E GHONEIM M M KHARASCH E D | 2001 | Anesthesiology2001，94，1： | 1 |
| 14 | (2002) Characterizing the flash flood hazards potential along the Red Sea Coast of Egypt 显示文摘 | Ghoneim E Amell N Foody G | 2002 | The Extremes of the Extremes: Extraordinary Floods2002，271，： | 1 |
| 15 | (2004) Predicting locations sensitive to flash flooding in an arid environment 显示文摘 | Foody G Ghoneim E Arnell N | 2004 | Journal of Hydrology2004，292，： | 1 |
| 16 | The incidence of awareness during anesthesia: a multicenter United States study 显示文摘 | Sebel P S Bowdle T A Ghoneim M M Rampil I J Padilla R E Gan T J | 2004 | Anesth Analg2004，99，： | 1 |
| 17 | Voltammetry and Determination of Metronidazole at a Carbon Fiber Microdisk Electrode显示文摘 | Bartlett P N Ghoneim E El-Hefnawy G | 2005 | Talanta2005，66，3： | 1 |
| 18 | Stability of spontaneous passive films on high strength Mo-containing stainless steels in aqueous solutions 显示文摘 | Heakal F E Ghoneim A A Fekry A M | 2007 | Journal of Applied Electrochemistry2007，37，： | 1 |
| 19 | Protective Effects of Curcumin Against Ischaemia/Reperfusion In sult in Rat Forebrain 显示文摘 | Ghoneim A I Abdel-Naim A B Khalifa A E | 2002 | PharmacolRes2002，46，3： | 1 |
| 20 | Voltammetric behavior and quantification of the sedative-hypnotic drug chlordiazepoxide in bulk form,pharmaceutical formulation and human serum at a mercury electrode显示文摘 | El-Hefnawey G B El-Hallag I S Ghoneim E M | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，34，： | 1 |
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