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| 1 | Growing locations: Industry location in a model of endogenous growth显示文摘 | Philippe Martin Gianmarco I.P. Ottaviano | 1999 | European Economic Review1999，，2： | 7 |
| 2 | Non-surgical treatment of hilar cholangiocarcinoma显示文摘Cancer of the biliary confluence also known as hilar cholangiocarcinoma(HC)or Klatskin tumor,is a rare type of neoplastic disease constituting approximately 40%-60%of intrahepatic malignancies,and 2% of all cancers.The prognosis is extremely poor and the majority of Klatskin tumors are deemed unresectable upon diagnosis.Most patients with unresectable bile duct cancer die within the first year after diagnosis,due to hepatic failure,and/or infectious complications secondary to biliary obstruction.Curative treatments include surgical resection and liver transplantation in highly selected patients.Nevertheless,very few patients are eligible for surgery or transplant at the time of diagnosis.For patients with unresectable HC,radiotherapy,chemotherapy,photodynamic therapy,and liver-directed minimally invasive procedures such as percutaneous image-guided ablation and intra-arterial chemoembolization are recommended treatment options.This review focuses on currently available treatment options for unresectable HC and discusses future perspectives that could optimize outcomes. | Riccardo Inchingolo Fabrizio Acquafredda Valentina Ferraro Letizia Laera Gianmarco Surico Alessia Surgo Alba Fiorentino Stefania Marini Nicola de'Angelis Riccardo Memeo Stavros Spiliopoulos | 2021 | World Journal of Gastrointestinal Oncology2021，13，11： | 5 |
| 3 | Clinical characteristics and prognostic impact of atrial fibrillation in patients with chronic heart failure显示文摘AIM To assess the prevalence, clinical characteristics and independent prognostic impact of atrial fibrillation(AF) in chronic heart failure(CHF) patients, and the potential protective effect of disease-modifying medications, particularly beta-blockers(BB). METHODS We retrospectively reviewed the charts of patients referred to our center since January 2004, and collected all clinical information available at their first visit. We assessed mortality to the end of June 2015. We compared patients with and without AF, and assessed the association between AF and all-cause mortality by multivariate Cox regression and Kaplan-Meyer analysis, particularly accounting for ongoing treatment with BB.RESULTS A total of 903 patients were evaluated(mean age 68 ± 12 years, 73% male). Prevalence of AF was 19%, ranging from 10% to 28% in patients ≤ 60 and ≥ 77 years, respectively. Besides the older age, patients with AF had more symptoms(New York Heart Association II-III 60% vs 44%), lower prevalence of dyslipidemia(23% vs 37%), coronary artery disease(28% vs 52%) and left bundle branch block(9% vs 16%). On the contrary, they more frequently presented with an idiopathic etiology(50% vs 24%), a history of valve surgery(13% vs 4%) and received overall more devices implantation(31% vs 21%). The use of disease-modifying medications(i.e., BB and ACE inhibitors/angiotensin receptor blockers) was lower in patients with AF(72% vs 80% and 71% vs 79%, respectively), who on the contrary were more frequently treated with symptomatic and antiarrhythmic drugs including diuretics(87% vs 69%) and digoxin(51% vs 11%). At a mean follow-up of about 5 years, all-cause mortality was significantly higher in patients with AF as compared to those in sinus rhythm(SR)(45% vs 34%, P value < 0.05 for all previous comparisons). However, in a multivariate analysis including the main significant predictors of allcause mortality, the univariate relationship between AF and death(HR = 1.49, 95%CI: 1.15-1.92) became not statistically significant(HR = 0.98, 95%CI: 0.73-1.32). Nonetheless, patients with AF not receiving BB treatment were found to have the worst prognosis, followed by patients with SR not receiving BB therapy and patients with AF receiving BB therapy, who both had similarly worse survival when compared to patients with SR receiving BB therapy.CONCLUSION AF was highly prevalent and associated with older age, worse clinical presentation and underutilization of disease-modifying medications such as BB in a population of elderly patients with CHF. AF had no independent impact on mortality, but the underutilization of BB in this group of patients was associated to a worse long-term prognosis. | Lorenzo Gigli Pietro Ameri Gianmarco Secco Gabriele De Blasi Roberta Miceli Alessandra Lorenzoni Francesco Torre Francesco Chiarella Claudio Brunelli Marco Canepa | 2016 | World Journal of Cardiology2016，8，11： | 4 |
| 4 | The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 Protein Forms an SCF Ubiquitin Ligase and Regulates Hypocotyl Elongation显示文摘由 ubiquitin proteasome 系统(不间断电源) 的蛋白质周转的规定是在优核质的主要 posttranslational 机制。UPS,的关键部件之一 COP9 signalosome (CSN ) ,调整 cullinring E3 ubiquitin ligases。在植物, CSN 参予多样的细胞、发展的进程,从到房间周期控制的轻发信号。在这个工作,我们孤立新植物特定的交往 CSN F 盒子蛋白质,我们它给 CFK1 (COP9 交往 F 盒子 KELCH 1 ) 取名。我们证明在 Arabidopsis thaliana, CFK1 是功能的 ubiquitin ligase 建筑群的一个部件。我们也证明那 CFK1 稳定性被 CSN 并且由 proteasome 依赖的解朊作用调整,并且那盏灯在胚轴导致 CFK1 抄本的累积。CFK1 的分析击倒,异种,和 overexpressing 幼苗显示 CFK1 由增加支持胚轴延伸房间尺寸。CSN 层次的减小提高弄空 CFK1 的幼苗的短胚轴显型,当 CSN 活动的完全的损失压制 CFK1-overexpressing 幼苗的长胚轴的显型时。我们建议那 CFK1 (并且它由 CSN 的规定) 细胞的机制的一个新奇部件正在控制胚轴延伸。 | Anna Franciosini Benedetta Lombardi Silvia lafrate Valeria.Pecce Giovanni Mele Leonardo Lupacchini Gianmarco Rinaldi Youichi Kondou Giuliana Gusmaroli Shiori Aki Tomohiko Tsuge Xing-Wang Deng Minami Matsui Paola Vittorioso Paolo Costantin Giovanna Serino | 2013 | Molecular Plant2013，6，5： | 3 |
| 5 | Global Income Divergence, Trade, and Industrialization: The Geography of Growth Take-Offs显示文摘 | Richard E. Baldwin Philippe Martin Gianmarco I. P. Ottaviano | 2001 | Journal of Economic Growth2001，，1： | 3 |
| 6 | Global Income Divergence, Trade, and Industrialization: The Geography of Growth Take-Offs显示文摘 | Richard E. Baldwin Philippe Martin Gianmarco I. P. Ottaviano | | Journal of Economic Growth0，，： | 2 |
| 7 | Monopolistic competition, trade, and endogenous spatial fluctuations显示文摘 | Gianmarco I.P. Ottaviano | 2001 | Regional Science and Urban Economics2001，，1： | 2 |
| 8 | Beyond the joint: Subclinical atherosclerosis in rheumatoid arthritis显示文摘Rheumatoid arthritis is a chronic autoimmune inflammatory disease associated with increased cardiovascular risk and higher mortality in respect to general population.Beyond joint disease,inflammation is the major determinant of accelerated atherosclerosis observed in rheumatoid arthritis.We review the relationship between inflammation,atherosclerosis and cardiovascular risk in rheumatoid arthritis,focusing on the assessment of subclinical atherosclerosis by functional and morphological methods.These tools include flow mediated dilatation,carotid intima-media thickness,ankle/brachial index,coronary calcium content,pulse wave analysis and serum biomarker of subclinical atherosclerosis. | Antongiulio Scarno Fabio Massimo Perrotta Francesca Cardini Alessia Carboni Gianmarco Annibali Ennio Lubrano Antonio Spadaro | 2014 | World Journal of Orthopedics2014，5，3： | 2 |
| 9 | Global Income Divergence, Trade and Industrialization: The Geograpby of Growth Take - offs显示文摘 | Richard Baldwin Philippe Martin Gianmarco Ottaviano | 1998 | Journal of Economic Growth1998，6，1： | 1 |
| 10 | 显示文摘 | Mazzotti Marco Zenoni Gianmarco | 2002 | AIChE Journal2002，48，1： | 1 |
| 11 | Growing Locations: Industry, Location in a Model of Endogenous Growth显示文摘 | Philippe Martin Ottaviano Gianmarco | 1999 | European Eco- nomic Review1999，43，2： | 1 |
| 12 | Comparison of Rebound Tonometer and Goldmann Handheld Applanation Tonometer in Congenital Glaucoma显示文摘 | Jose M. Martinez-de-la-Casa Julian Garcia-Feijoo Federico Saenz-Frances Gianmarco Vizzeri Ana Fernandez-Vidal Carmen Mendez-Hernandez Julian Garcia-Sanchez | 2009 | Journal of Glaucoma2009，，1： | 1 |
| 13 | The influence of vehicle front-end design on pedestrian ground impact显示文摘 | GIANMARCO Crocetta SIMONE Piantini MARCO Pierini | 2015 | Accident Analysis and Prevention2015，79，： | 1 |
| 14 | Cataract sur-gery and glaucoma current opinion in ophthalmology显示文摘 | VIZZERI GIANMARCO WEINREB | | 0，，01： | 1 |
| 15 | Agglomeration and Trade Revisited 显示文摘 | Ottaviano Gianmarco Tabuehi Takatoshi Thisse Jaques - Francois | 2002 | International Economic Review2002，，3： | 1 |
| 16 | Chapter 58 Agglomeration and economic geography显示文摘 | Gianmarco Ottaviano | 2004 | Handbook of Regional and Urban Economics2004，，： | 1 |
| 17 | An early warning system for detecting GSM-R wireless interference in the high-speed railway infrastructure显示文摘 | Gianmarco Baldinia Igor Nai Fovinoa Marcelo Maseraa | 2010 | International Journal of Critical Infrastructure Protection2010，3，34： | 1 |
| 18 | Global Income Divergence, Trade, and Industrialization: The Geography of Growth Take-Offs显示文摘 | Richard E. Baldwin Philippe Martin Gianmarco I. P. Ottaviano | 2001 | Journal of Economic Growth2001，，1： | 1 |
| 19 | Monopolistic Competition, Trade, and Endogenous Spatial Fluctuations显示文摘 | Ottaviano Gianmarco | 2001 | Regional Science and Urban Economics2001，，2： | 1 |
| 20 | Global Income Divergence, Trade, and Industrialization: The Geography of Growth Take-Offs显示文摘 | Richard E. Baldwin Philippe Martin Gianmarco I. P. Ottaviano | 2001 | Journal of Economic Growth2001，，1： | 1 |
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