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| 1 | Surveillance for early diagnosis of hepatocellular carcinoma: How best to do it?显示文摘Surveillance for hepatocellular carcinoma(HCC)is considered a standard of care for patients with chronic liver disease who are at risk of developing this malignancy.Several studies have shown that surveillance can improve the prognosis of patients diagnosed with HCC through an increased likelihood of application of curative or effective treatments.Repetition of liver ultrasonography(US)every 6 mo is the recommended surveillance program to detect early HCCs,and a positive US has to entrain a well-defined recall policy based on contrast-enhanced,dynamic radiological imaging or biopsy for the diagnosis of HCC.Although HCC fulfills the accepted criteria regarding cost-effective cancer screening and surveillance,the implementation of surveillance in clinical practice is defective and this has a negative impact on the cost-effectiveness of the procedure.Education of both physicians and patients is of paramount importance in order to improve the surveillance application and its benefits in patients at risk of HCC.The promotion of specific educational programs for practitioners,clinicians and patients is instrumental in order to expand the correct use of surveillance in clinical practice and eventually improve HCC prognosis. | Edoardo G Giannini Alessandro Cucchetti Virginia Erroi Francesca Garuti Federica Odaldi Franco Trevisani | 2013 | World Journal of Gastroenterology2013，19，47： | 10 |
| 2 | Hepatitis C virus-related lymphoproliferative disorders:An overview显示文摘Hepatitis C virus (HCV) is a global health problem affecting 3% of the world’s population (about 180 million) and a cause of both hepatic and extrahepatic diseases. B-cell lymphoproliferative disorders, whose prototype is mixed cryoglobulinemia, represent the most closely related as well as the most investigated HCV- related extrahepatic disorder. The association between extrahepatic (lymphoma) as well as hepatic malignancies (hepatocellular carcinoma) has justified the inclusion of HCV among human cancer viruses. HCV-associated manifestations also include porphyria cutanea tarda, lichen planus, nephropathies, thyreopathies, sicca syndrome, idiopathic pulmonary fibrosis, diabetes, chronic polyarthritis, sexual dysfunctions, cardiopathy/ atherosclerosis, and psychopathological disorders. A pathogenetic link between HCV virus and some lymphoproliferative disorders was confirmed by their responsiveness to antiviral therapy, which is now considered the first choice treatment. The aim of the present paper is to provide an overview of extrahepatic manifestations of HCV infection with particular attention to B-cell lymphoproliferative disorders. Available pathogenetic hypotheses and suggestions about the most appropriate, currently available, therapeutic approaches will also be discussed. | Anna Linda Zignego Carlo Giannini Clodoveo Ferri | 2007 | World Journal of Gastroenterology2007，13，17： | 5 |
| 3 | Radiomics in colorectal cancer patients显示文摘The main therapeutic options for colorectal cancer are surgical resection and adjuvant chemotherapy in non-metastatic disease.However,the evaluation of the overall adjuvant chemotherapy benefit in patients with a high risk of recurrence is challenging.Radiological images can represent a source of data that can be analyzed by using automated computer-based techniques,working on numerical information coded within Digital Imaging and Communications in Medicine files:This image numerical analysis has been named“radiomics”.Radiomics allows the extraction of quantitative features from radiological images,mainly invisible to the naked eye,that can be further analyzed by artificial intelligence algorithms.Radiomics is expanding in oncology to either understand tumor biology or for the development of imaging biomarkers for diagnosis,staging,and prognosis,prediction of treatment response and diseases monitoring and surveillance.Several efforts have been made to develop radiomics signatures for colorectal cancer patient using computed tomography(CT)images with different aims:The preoperative prediction of lymph node metastasis,detecting BRAF and RAS gene mutations.Moreover,the use of delta-radiomics allows the analysis of variations of the radiomics parameters extracted from CT scans performed at different timepoints.Most published studies concerning radiomics and magnetic resonance imaging(MRI)mainly focused on the response of advanced tumors that under-went neoadjuvant therapy.Nodes status is the main determinant of adjuvant chemotherapy.Therefore,several radiomics model based on MRI,especially on T2-weighted images and ADC maps,for the preoperative prediction of nodes metastasis in rectal cancer has been developed.Current studies mostly focused on the applications of radiomics in positron emission tomogra-phy/CT for the prediction of survival after curative surgical resection and assessment of response following neoadjuvant chemoradiotherapy.Since colorectal liver metastases develop in about 25%of patients with colorectal carcinoma,the main diagnostic tasks of radiomics should be the detection of synchronous and metachronous lesions.Radiomics could be an additional tool in clinical setting,especially in identifying patients with high-risk disease.Nevertheless,radiomics has numerous shortcomings that make daily use extremely difficult.Further studies are needed to assess performance of radiomics in stratifying patients with high-risk disease. | Riccardo Inchingolo Cesare Maino Roberto Cannella Federica Vernuccio Francesco Cortese Michele Dezio Antonio Rosario Pisani Teresa Giandola Marco Gatti Valentina Giannini Davide Ippolito Riccardo Faletti | 2023 | World Journal of Gastroenterology2023，29，19： | 4 |
| 4 | Application of the platelet count/spleen diameter ratio to rule out the presence of oesophageal varices in patients with cirrhosis: A validation study based on follow-up显示文摘 | E.G. Giannini F. Botta P. Borro P. Dulbecco E. Testa C. Mansi V. Savarino R. Testa | 2005 | Digestive and Liver Disease2005，，10： | 3 |
| 5 | Giant colonic diverticulum,clinical presentation,diagnosis and treatment: Systematic review of 166 cases显示文摘AIM: To investigate the clinical presentation,diagnosis,and treatment of giant colonic diverticulum(GCD,by means of a complete and updated literature review).GCD is a rare manifestation of diverticular disease of the colon.Less than 200 studies on GCD were published in the literature,predominantly case reports or small patient series.METHODS: A systematic review of the literature was performed using the Embase and PubM ed databases toidentify all the GCD studies.The following MESH search headings were used: 'giant colonic diverticulum'; 'giant sigmoid diverticulum'.The 'related articles' function was used to broaden the search,and all of the abstracts,studies,and citations were reviewed by two authors.The following outcomes were of interest: the disease and patient characteristics,study design,indications for surgery,type of operation,and postoperative outcomes.Additionally,a subgroup analysis of cases treated in the last 5 years was performed to show the current trends in the treatment of GCD.A GCD case in an elderly patient treated in our department by a sigmoidectomy with primary anastomosis and a diverting ileostomy is presented as a typical example of the disease.RESULTS: In total,166 GCD cases in 138 studies were identified in the literature.The most common clinical presentation was abdominal pain,which occurred in 69% of the cases.Among the physical signs,an abdominal mass was detected in 48% of the cases,whereas 20% of the patients presented with fever and 14% with abdominal tenderness.Diagnosis is based predominantly on abdominal computed tomography.The most frequent treatment was colic resection with en-bloc resection of the diverticulum,performed in 57.2% of cases,whereas Hartmann's procedure was followed in 11.4% of the cases and a diverticulectomy in 10.2%.An analysis of sixteen cases reported in the last 5 years showed that the majority of patients were treated with sigmoidectomy and en-bloc resection of the diverticulum; the postoperative mortality was null,morbidity was very low(1 patient was hospitalized in the intensive care unit for postoperative hypotension),and the patients were discharged 4-14 d after surgery.CONCLUSION: Giant colonic diverticulum is a rare manifestation of diverticular diseases.Surgical treatment,consisting predominantly of colonic resection with en bloc resection of the diverticulum,is thepreferred option for GCD and guarantees excellent results. | Giuseppe Nigri Niccolò Petrucciani Giulia Giannini Paolo Aurello Paolo Magistri Marcello Gasparrini Giovanni Ramacciato | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 6 | Peripheral blood cytopaenia limiting initiation of treatment in chronic hepatitis C patients otherwise eligible for antiviral therapy显示文摘 | Edoardo G. Giannini Simona Marenco Valentina Fazio Giulia Pieri Vincenzo Savarino Antonino Picciotto | 2012 | Liver Int2012，，7： | 2 |
| 7 | Survival benefit of liver resection for patients with hepatocellular carcinoma across different Barcelona Clinic Liver Cancer stages: a multicentre study显示文摘 | Alessandro Vitale Patrizia Burra Anna Chiara Frigo Franco Trevisani Fabio Farinati Gaya Spolverato Michael Volk Edoardo G. Giannini Francesca Ciccarese Fabio Piscaglia Gian Lodovico Rapaccini Mariella Di Marco Eugenio Caturelli Marco Zoli Franco Borzio Gi | 2014 | Journal of Hepatology2014，，： | 2 |
| 8 | Eltrombopag Increases Platelet Numbers in Thrombocytopenic Patients With HCV Infection and Cirrhosis, Allowing for Effective Antiviral Therapy显示文摘 | Nezam H. Afdhal Geoffrey M. Dusheiko Edoardo G. Giannini Pei–Jer Chen Kwang–Hyub Han Aftab Mohsin Maribel Rodriguez–Torres Sorin Rugina Igor Bakulin Eric Lawitz Mitchell L. Shiffman Ghias–Un–Nabi Tayyab Fred Poordad Yasser Mostafa Kamel Andres Brainsky Ja | 2014 | Gastroenterology2014，，2： | 2 |
| 9 | Post-synthesis phase and shape evolution of CsPbBr3 colloidal nanocrystals: The role of ligands显示文摘The surface chemistry of colloidal cesium lead bromide (CsPbBr3) nanocrystals is decisive in determining the stability and the final morphology of this class of materials,characterized by ionic structure and a high defect tolerance factor.Here,the high sensitivity of purified colloidal nanocubes of CsPbBr3 to diverse environmental condition (solvent dilution,ageing,ligands post synthetic treatment) in ambient atmosphere is investigated by means of a comprehensive morphological (electron microscopy),structural (θ/2θ X-ray diffraction (XRD) and grazing incidence wide angle scattering (GIWAXS)),and spectroscopic chemical (1H nuclear magnetic resonance (NMR),nuclear Overhauser effect spectroscopy (NOESY),absorption and emission spectroscopy) characterization.The aging and solvent dilution contribute to modify the nanocrystal morphology,due to a modification of the ligand dynamic.Moreover,we establish the ability of aliphatic carboxylic acids and aikyl amines ligands to induce,even in a post preparative process at room temperature,structural,morphological and spectroscopic variations.Upon post synthesis alkyl amine addition,in particular of oleyl amine and octyl amine,the highly green emitting CsPbBr3 nanocubes effectively tum into one-dimensional (1 D) thin tetragonal nanowires or lead halide deficient rhombohedral zero-dimensional (0D) Cs4PbBr6 structures with a complete loss of fluorescence.The addition of an alkyl carboxylic acid,as oleic and nonanoic acid,produces the transformation of nanocubes into still emitting orthorombic two-dimensional (2D) nanoplates.The acid/base equilibrium between the native and added ligands,the edsorbed/free ligands dynamic in solution and the ligand solubility in non-polar solvent contribute to render CsPbBr3 particularly sensitive to environmental and processing conditions and,therefore prone to undergo to structural,morphological and,hence spectroscopic,transformations. | Elisabetta Fanizza Francesca Cascella Davide Altamura Cinzia Giannini Annamaria Panniello Leonardo Triggiani Francesca Panzarea Nicoletta Depalo Roberto Grisorio Gian Paolo Suranna Angela Agostiano M.Lucia Curri Marinella Striccoli | 2019 | Nano Research2019，12，5： | 2 |
| 10 | Hepatitis C virus RNA localization in human carotid plaques显示文摘 | Maria Boddi Rosanna Abbate Benedetta Chellini Betti Giusti Carlo Giannini Giovanni Pratesi Luciana Rossi Carlo Pratesi Gian Franco Gensini Laura Paperetti Anna Linda Zignego | 2009 | Journal of Clinical Virology2009，，1： | 2 |
| 11 | Antiproliferative and Proapoptotic Activity of Sunitinib on Endothelial and Anaplastic Thyroid Cancer Cells via Inhibition of Akt and ERK1/2 Phosphorylation and by Down-Regulation of Cyclin-D1显示文摘 | Teresa Di Desidero Anna Fioravanti Paola Orlandi Bastianina Canu Riccardo Giannini Nicla Borrelli Shan Man Ping Xu Gabriella Fontanini Fulvio Basolo Robert S. Kerbel Giulio Francia Romano Danesi Guido Bocci | 2013 | The Journal of Clinical Endocrinology & Metabolism2013，，9： | 2 |
| 12 | Liver metastases:The role of magnetic resonance imaging显示文摘The liver is one of the organs most commonly involved in metastatic disease,especially due to its unique vascularization.It’s well known that liver metastases represent the most common hepatic malignant tumors.From a practical point of view,it’s of utmost importance to evaluate the presence of liver metastases when staging oncologic patients,to select the best treatment possible,and finally to predict the overall prognosis.In the past few years,imaging techniques have gained a central role in identifying liver metastases,thanks to ultrasonography,contrast-enhanced computed tomography(CT),and magnetic resonance imaging(MRI).All these techniques,especially CT and MRI,can be considered the noninvasive reference standard techniques for the assessment of liver involvement by metastases.On the other hand,the liver can be affected by different focal lesions,sometimes benign,and sometimes malignant.On these bases,radiologists should face the differential diagnosis between benign and secondary lesions to correctly allocate patients to the best management.Considering the above-mentioned principles,it’s extremely important to underline and refresh the broad spectrum of liver metastases features that can occur in everyday clinical practice.This review aims to summarize the most common imaging features of liver metastases,with a special focus on typical and atypical appearance,by using MRI. | Cesare Maino Federica Vernuccio Roberto Cannella Francesco Cortese Paolo NiccolòFranco Clara Gaetani Valentina Giannini Riccardo Inchingolo Davide Ippolito Arianna Defeudis Giulia Pilato Davide Tore Riccardo Faletti Marco Gatti | 2023 | World Journal of Gastroenterology2023，29，36： | 2 |
| 13 | Barcelona Clinic Liver Cancer staging and transplant survival benefit for patients with hepatocellular carcinoma: a multicentre, cohort study显示文摘 | Alessandro Vitale Rafael Ramirez Morales Giacomo Zanus Fabio Farinati Patrizia Burra Paolo Angeli Anna Chiara Frigo Paolo Del Poggio Gianludovico Rapaccini Maria Anna Di Nolfo Luisa Benvegnù Marco Zoli Franco Borzio Edoardo Giovanni Giannini Eugenio Catur | 2011 | Lancet Oncology2011，，7： | 2 |
| 14 | On the cyclic behaviour of new pier-to-deck connections for short-medium span composite I-girder bridges显示文摘Short-medium span steeleconcrete composite I-girder bridges are becoming more and more popular, because of the reduced construction time and costs. The light weight renders them particularly suitable also is seismic areas, even though this advantage has not been yet adequately investigated. In fact, in case of seismic loading, significant tensile forces might be exhibited at the bottom flange of the steel girder, especially when monolithic connection between deck and pier is adopted, and the connection, conceived for sustaining prevailing hogging bending moments, could experience an excessive damage.With this aim, the cyclic behaviour of new pier-to-deck joints involving the use of concrete cross-beams(CCB) has been recently analysed within the European project(SEQBRI). This paper deals with the results of a wide experimental investigation of these new joints,performed with the aim of characterizing their hysteretic behaviour. Three different typologies were tested: one designed according to the German standard DIN-FB-104, generally utilized for gravity loads only, and other two types proposed for bridges located in low(VAR-1) and medium(VAR-2) seismicity. A series of displacement-imposed cyclic tests highlighted a good seismic behaviour of all the tested solutions. In particular, the DIN-FB-104 VAR C and VAR-2 displayed a similar global behaviour in terms of maximum force and displacement, but with a more pronounced crack development and buckling of steel girders of the first solution. The VAR-2 also avoids possible pull-out phenomena in the CCB thanks to the beneficial action of pre-stressing bars.A damage analysis of the proposed connections was finally performed in view of the application of the performance-based earthquake engineering methodology and the quantification the seismic performance of this bridge typology, which was among the aims of SEQBRI project. | Fabrizio Paolacci Renato Giannini Silvia Alessandri Daniele Corritore | 2018 | Journal of Traffic and Transportation Engineering(English Edition)2018，5，6： | 2 |
| 15 | Influence of the mucosal epithelium microenvironment on langerhans,cells:implications for the development of squamous intraepithelia lesions of the cervix显示文摘 | Giannini SL Hubert P Doyen J | 2002 | Int J Cancer2002，97，5： | 1 |
| 16 | Lower limb compartment syndrome associated with Lloyd-Davies/lithotomy position in colorectal surgery显示文摘 | Pecora RA Giannini CG | 2004 | Hepatogastroenterology2004，51，55： | 1 |
| 17 | Intermittent high glucose concentrations reduce neuronal precursor survival by altering the IGF system:the involvement of the neuroprotective factor DHCR24(Seladin-1)显示文摘 | Giannini S Benvenuti S Luciani P | 2008 | J Endocrinol2008，198，3： | 1 |
| 18 | Etanercept in children with polyarticular juvenile rheumatoid arthritis 显示文摘 | Lovell D J Giannini EH ReiffA | 2000 | New Engl J Med2000，342，11： | 1 |
| 19 | Dargemont CDirect association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha显示文摘 | Weil R Sirma H Giannini C | 1999 | Mol Cell Biol1999，19，9： | 1 |
| 20 | Morphology and thickness of the diffusion of resin through demineralized or unconditioned dentinal matrix显示文摘 | Arrais CA Giannini M | 2002 | Pesqui Odontol Bras2002，16，2： | 1 |
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