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| 1 | Rhabdomyolysis after midazolam administration in a cirrhotic patient treated with atorvastatin显示文摘The administration of statins in patients with liver disease is not an absolute contraindication. Hepatotoxicity is a rare and often dose-related event and in the literature there are only a few described cases of fatal rhab-domyolysis in patients with chronic liver disease after statin administration. During treatment with 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors,the factors responsible for myopathy may either be related to the patient,or due to interactions with other medications that are metabolic substrates of the same isozymes and therefore able to increase blood statin concentration. The most important side effects consist of increased transaminase levels,abdominal pain or muscle weakness,increased serum levels of creatine kinase and rhabdomyolysis. In this article we report a case of fatal rhabdomyolysis with acute renal failure after gastric endoscopy,where midazolam was used as a sedation agent in a patient with chronic liver disease treated with a high dose of atorvastatin. Therefore,we suggest paying particular attention to the potential risks of associating atorvastatin and midazolam in patients with chronic liver disease who need to undergo gastric endoscopy. | Antonietta Gigante Gianluca Di Lazzaro Giraldi Maria Ludovica Gasperini Biagio Barbano Marta Liberatori Liborio Sardo Francesca Di Mario Antonella Giorgi Filippo Rossi-Fanelli Antonio Amoroso | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 6 |
| 2 | Transphyseal separation of the distal humerus in newborns显示文摘 | Cosimo Gigante Sunil Gurpur Kini Carlo Origo Andrea Volpin | 2017 | Chinese Journal of Traumatology2017，20，3： | 6 |
| 3 | Patients with hematological malignancies and serological signs of prior resolved hepatitis B显示文摘Hepatitis B virus (HBV) infection affects a large part of the world population. Within the different virological HBV categories that have been identified, patients with occult HBV infection represent a peculiar group. These individuals harbor a replication competent virus, inhibited in its replicative function. Accordingly, cases of reactivations have been observed in immunosuppressed individuals who lose immunological control over the infection. Patients with hematological malignancies (HM) are treated with intense myeloand immunosuppres-sive chemotherapy regimens which favor HBV reactivation. This event can have severe consequences, such as hepatitis flare, hepatic failure and even death. In addition, it can lead to delays or interruptions of curative treatments, resulting in a decreased disease free and overall survival. In this review, we will examine the event of HBV reactivation in patients with signs of resolved HBV infection undergoing treatment for HM and propose possible management strategies. | Massimo Marignani Elia Gigante Paola Begini Alfredo Marzano Michela di Fonzo Ilaria Deli Sara Gallina Maria Christina Cox Gianfranco Delle Fave | 2012 | World Journal of Gastrointestinal Oncology2012，4，3： | 3 |
| 4 | Coronal plane deformity around the knee in the skeletally immature population:A review of principles of evaluation and treatment显示文摘Coronal plane deformity around the knee,also known as genu varum or genu valgum,is a common finding in clinical practice for pediatricians and orthopedists.These deformities can be physiological or pathological.If untreated,pathological deformities can lead to abnormal joint loading and a consequent risk of premature osteoarthritis.The aim of this review is to provide a framework for the diagnosis and management of genu varum and genu valgum in skeletally immature patients. | Valentino Coppa Mario Marinelli Roberto Procaccini Danya Falcioni Luca Farinelli Antonio Gigante | 2022 | World Journal of Orthopedics2022，13，5： | 2 |
| 5 | Identification and characterization of Trichoderma species aggressive to Pleurotus in Italy显示文摘In the late 1980’s the deve lop ment of a severe epidemic of green mold caused by Trichoderma spp. was not ed in the commercial production of Agaricus bisporus (champignon) in the U nited Kingdom, North America, Spain and Holland, which caused extensive economic losses. The parasitic fungi isolated from the edible mushroom belonged to four biotypes, Th1, Th2, Th3 and Th4 of T. harzianum. However, among these biotypes, only Th2 (since c lassified as T. aggressivum f. europaeum) and Th4 (T. aggressivum f. aggressivum) were identified as the fungi causing problems in Agaricus production. In general, mushroom compost hosts both aggressive and innocuous is olates of Trichoderma, which are not morphologically distinguishable. Abo ut four years ago, a problem with green mold became apparent in the production o f Pleurotus ostreatus in Northern Italy, which eventually developed to a c risis situation in the South two years later and threatened to seriously comprom ise the Pleurotus market. This study was initiated to: isolate and identif y the aggressive fungi, then morphologically, physiologically and genetically characterize the isolates, dete rmine the source and phases of infection, and study methods of control. Samples were obtained from different phases of compost preparation at the locality of a major producer and supplier of compost to the mushroom industry in Southern Ital y, and microbial counts were conducted. Although the presence of Trichoderma was detected in the initial stages of composting, this value was reduced to zero from the phase of pasteurization to seeding with Pleurotus. Trichoderma infestations were noted in the packaged Pleurotus bales at various time s during the incubation phase (7-15 days after seeding) and after shipping to th e mushroom greenhouses, where the pathogen infestations greatly reduced the qual ity and quantity of the mushroom yield, as well as the number of potential harvest cycles. Preliminary r esults from the morphological and genetic characterization of Trichoderma isolates parasitic to Pleurotus indicated that they are different from bot h T. aggressivum forms parasitic to Agaricus, and the majority of the isolates probably belong to the species T. harzianum. In vitr o confrontation plates were performed with 26 isolates of aggressive Trich oderma obtained from compost, three Trichoderma isolates used in biolog ical control and 12 varieties of Pleurotus. No inhibitory effect was obse rved between any of the Trichoderma isolates with Pleurotus, althou gh some growth inhibition was caused by the biocontrol isolates of Trichoderm a on some of the aggressive isolates. The temperature optimum for Pleurotus growth was at 28 ℃, whereas Trichoderma grew well at a wider range (20- 28 ℃), and exceeded the growth rate of Pleurotus by three times at 25 ℃. T he pH optimum for the growth of Pleurotus was alkaline (pH 8-9) whereas Trichoderma preferred acidic-neutral pH (5-7) . Various commercial fungicides used in agriculture (procloraz, thiabendazole, dichloran, benomyl, p r opiconazole, thiofanatomethyl) were tested against the aggressive and biocontro l isolates of Trichoderma, as well as the different varieties of Pleuro tus to determine dose response curves and combinations that would inhibit spo re germination, mycelial growth and subsequent sporulation. Both procloraz and thiabendazole, which are pesticides allowed in e dible mushroom production, were found to control the growth of the aggressive Trichoderma isolates and did not have a negative effect on Pleurotus. | Woo S L Di Benedetto P Senatore M Abadi K Gigante S Soriente I Ferraioli S Scala F Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 6 | Synthesis and antiviral evaluation of benzimidazoles,quinoxalines and indoles from dehydroabietic acid显示文摘 | Fonseca T Gigante B Marques M M | 2004 | Bioorganic Med Chem2004，12，1： | 1 |
| 7 | A general algorithm for multi-dimensional Cauchy principal value integral in the boundary element methods显示文摘 | Gigante A | 1990 | Tran ASME J Appl Mech1990，57，： | 1 |
| 8 | Systemic lupus erythemato-sus and renal involvement:which role of citokines expression显示文摘 | Gigante A Amoroso D Ferri F | 2006 | Eur Rev Med Pharmacol Sci2006，10，5： | 1 |
| 9 | Antimicrobial activity of resin acid derivatives显示文摘 | Savluchinske-Feio S Curto M J M Gigante B | 2006 | Ap- pl Microbiol Biotechnol2006，72，3： | 1 |
| 10 | Catechols from abietic acid-synthesis and evaluation as bioactive compounds显示文摘 | GIGANTE B SANTOS C SILVA A M | 2003 | Bioorganic and Medicinal Chemistry2003，11，8： | 1 |
| 11 | Musculoskele- tal manifestations in pediatric acute leukemia 显示文摘 | Sinigaglia R Gigante C Bisinella G | 2008 | J Pediatr Or- thop2008，28，： | 1 |
| 12 | Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid 显示文摘 | FONSECA T GIGANTE B MARQUES M M | 2004 | Bioorganic & Medicinal Chemistry2004，12，1： | 1 |
| 13 | CD2AP mu- tations are associated with sporadic nephritic syndrome and focal segmental glomerulosclerosis显示文摘 | Gigante M Pontrelli P Montemumo E | 2009 | Nephrol Dial Trans- plant2009，24，6： | 1 |
| 14 | Structure and function of pla- centa growth factor 显示文摘 | De Falco S Gigante B Persico MG | 2002 | Trends Cardiovasc Med2002，12，6： | 1 |
| 15 | On the activi ty of ehiral chromium salen complexes eovalently bound to solid silicates for the enantioselective epoxide ring opening显示文摘 | Baleiz? o C Gigante B Sabater M J | 2002 | Applied Catalysis A : General2002，228，： | 1 |
| 16 | Size at bigh,weight gain in infancy and childhood,and adult diabetes risk in five low-or middle-income country birth cohorts显示文摘 | NORRIS SA OSMOND C GIGANTE D | | 0，，01： | 1 |
| 17 | Physical activity change during adolescence:as ystematic review and a pooled analysis显示文摘 | Dumith SC Gigante DP Domingues MR | | 0，，03： | 1 |
| 18 | Antimicrobial activity of resin acid derivatives显示文摘 | Savluchinske-Feio S Curto M J M Gigante B | 2006 | Applied Microbiology and Bio- technology2006，72，3： | 1 |
| 19 | Clinical features and long-term outcome of nephrotic syndrome associated with heterozygous NPHS1 and NPHS2 mutations显示文摘 | CARIDI G GIGANTE M RAVANI P | 2009 | Clin J Am Soc Nephrol2009，4，6： | 1 |
| 20 | Insight into tubulin regulation from a complex with colchicines and a stathmin-like domain显示文摘 | Ravelli R B G Gigant B Curmi P A | 2004 | Nature2004，428，： | 1 |
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