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| 1 | Role of bacterial and genetic factors in gastric cancer in Costa Rica显示文摘AIM: To evaluate several risk factors for gastric cancer (GC) in Costa Rican regions with contrasting GC incidence rate (GCIR). METHODS: According to GCIR, 191 Helicobacter pylori (H pylori)-positive patients were classified into groups A (high GCIR, n = 101) and B (low GCIR, n = 90). Human DNA obtained from biopsy specimens was used in the determination of polymorphisms of the genes coding for interleukin (IL)-1β and IL-10 by PCR-RFLP, and IL-1RN by PCR. H pylori DNA extractions obtained from clinical isolates of 83 patients were used for PCR-based genotyping of H pylori cagA, vacA and babA2. Human DNA from gastric biopsies of 52 GC patients was utilized for comparative purposes. RESULTS: Cytokine polymorphisms showed no association with GCIR variability. However, gastric atrophy, intestinal metaplasia and strains with different vacA genotypes in the same stomach (mixed strain infection) were more frequently found in group A than in group B, and cagA and vacA s1b were signif icantly associated with high GCIR (P = 0.026 and 0.041, respectively). IL- 1β+3954_T/C (OR 2.1, 1.0-4.3), IL-1RN*2/L (OR 3.5, 1.7-7.3) and IL-10-592_C/A (OR 3.2, 1.5-6.8) were individually associated with GC, and a combination of these cytokine polymorphisms with H pylori vacA s1b and m1 further increased the risk (OR 7.2, 1.4-36.4). CONCLUSION: Although a proinflammatory cytokine genetic profile showed an increased risk for developing GC, the characteristics of H pylori infection, in particular the status of cagA and vacA genotype distribution seemed to play a major role in GCIR variability in Costa Rica. | Sergio A Con Hiroaki Takeuchi Gil R Con-Chin Vicky G Con-Chin Nobufumi Yasuda Reinaldo Con-Wong | 2009 | World Journal of Gastroenterology2009，15，2： | 9 |
| 2 | Stepped-impedance lowpass filters with spurious pass-band suppression显示文摘 | J Garcia-Garcia J Bonache F Falcone J D Baena F Martin I Gil T Lopetegi M A G Laso A Marcotegui R Marques M Sorolla | 2004 | Electronic Letters2004，40，14： | 1 |
| 3 | Molecular characterization of partial chromosome 21 aneuploidies by fluorescent PCR显示文摘 | Valero R Marfany G Gil BR | 1999 | J Med Genet1999，36，： | 1 |
| 4 | A robust pre- dictive current control for three-phase grid-connected inver-ters 显示文摘 | MORENO J C HUERTA J M E GIL R G ct al | 2009 | IEEE Transactions on Industrial Electronics2009，56，6： | 1 |
| 5 | Photon -sieve lithography 显示文摘 | Menon R Gil D Barbastathis G | 2005 | J Opt Soc Am A2005，22，2： | 1 |
| 6 | Characterization and supercritical carbon dioxide extraction ofwalnut oil显示文摘 | Oliveira R Rodrigues M F Bernardo - Gil M G | 2002 | J Am Oil Chem Soc2002，79，3： | 1 |
| 7 | A screened hydrogenic model using analytical potential显示文摘 | Rubiano J G Rodriguez R Gil J M | 2002 | JQSRT2002，72，： | 1 |
| 8 | Role of Bcl-2 family members on apoptosis: what we have learned from knockout mice 显示文摘 | ROSET R ORTET L GIL G | 2007 | Front Biosci2007，12，20： | 1 |
| 9 | Calculation of the ionization State for LTE plasmas using a new relativistic-screened hydrogenic model based on analytical potentials显示文摘 | Rubiano J G Rodriguez R Gil J M | 2002 | Laser and Particle Beams2002，20，： | 1 |
| 10 | Leg length and offset fol owing hip resurfacing and hip replacement显示文摘 | Ahmad R Gil espie G Annamalai S | | 0，，02： | 1 |
| 11 | Effects of intrauterine food restriction and long-term dietary supple mentation with L-arginine on age-related changes in renal function and structure of rats 显示文摘 | Gil F Z Lucas S R Gomes G N | 2005 | Pediatr Res2005，57，51： | 1 |
| 12 | 2005, Structural and ultrastructural changes on muscle tissue of sea bass, Dicemtrarchus labrax L, after cooking and freezing显示文摘 | Ayala M D Albors O L Blanco A Garcia-Aleazar A Abellan E Zarzosa R G Gil F | 2005 | Aquaculture2005，250，12： | 1 |
| 13 | Out- break of multiresistant and extended spectrum 13 - lactamase produ- cing Klebsiella pneumoniae in a high risk neonatal unit 显示文摘 | GONZOLEZ R A C GIL G F SOLORZANO R M | 2011 | Rev Chilena Infectol2011，28，1： | 1 |
| 14 | An integrated decision support system deal- ing with qualitative and quantitative objectives for enterprise software selection 显示文摘 | Ceyda G u ng?r ?en Hayri Bara?l? Sel?uk ?en H u seyin Ba?l?gil | 2009 | Expert Systems with Applications2009，36，3： | 1 |
| 15 | Photon-sieve lithography显示文摘 | MENON R GIL D BARBASTATHIS G | 2005 | JOSA2005，22，： | 1 |
| 16 | Role of Bcl-2 family members on apoptosis: what we have learned from knock-out mice 显示文摘 | ROSET R ORTET L GIL G | 2007 | FrontBiosci2007，12，20： | 1 |
| 17 | A robust predictive current control for three-phase inverter-based distributed generation显示文摘 | Moreno J C Huerta J M E Gil R G | 2009 | IEEE Transactions on Industrial Electronics2009，56，6： | 1 |
| 18 | Role of Bel-2 family members on apoptosis:what we have learned from knock-out mice 显示文摘 | ROSET R ORTET L GIL G | 2007 | Frontiers in Bioscience-landmark2007，12，20： | 1 |
| 19 | A memetic algorithm applied to the design of water distribution netwoks 显示文摘 | Bofios R Gil C Reca J Montoya F G | 2010 | Applied Soft Computing2010，，10： | 1 |
| 20 | A robust predictive current control for three-Phase grid-connected inverters显示文摘 | Moreno J C Huerta J M E Gil R G | 2009 | IEEE Transactions on Industrial Electronic2009，56，6： | 1 |
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