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| 1 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 2 | Improved Pt/Au and W/Pt/Au Schottky contacts on n-type ZnO using ozone cleaning显示文摘 | IP K GILA B P ONSTINE A H LAMBERS E S HEO Y W BAlK K H NORTON D P PEARTON S J KIM S LAROCHE J R REN F | 2004 | Appl Phys Lett2004，84，25： | 1 |
| 3 | Biomass gasification in atmospheric and bubbling fluidized bed:Effect of the type of gasifying agent on the product distribution显示文摘 | GILA J CORELLAB J AZNARA M P CABALLERO M A | 1999 | Biomass Bioenergy1999，17，5： | 1 |
| 4 | Sexual harassment of nurses and nursing students显示文摘 | Gila B Chava P Mally E | 2003 | J Adv Nurs2003，42，6： | 1 |
| 5 | Effect of ozone cleaning on Pr/Au and W/Pt/Au Schottky contacts to n-type ZnO显示文摘 | Ip K Gila B P Onstine A H | 2004 | Applied Surface Science2004，236，： | 1 |
| 6 | Analysis of the interdisciplinary nature of library and information science 显示文摘 | GILA P | 2010 | Journal of Librarianship and Information Science2010，42，4： | 1 |
| 7 | Novel dielectrics for gate oxides and surface passivation on GaN显示文摘 | Gila B P Thaler G T Onstine A H | 2006 | Solid State Electron2006，50，： | 1 |
| 8 | Use of Real Time Three-Dimensional Transesophageal Echocardiography in Intracardiac Catheter Based Interventions 显示文摘 | Gila P Roberto ML Miguel Angel G-F | 2009 | J Am Soc Echocardiog2009，22，： | 1 |
| 9 | Dry Etching of Mg- CaO Gate Dielectric and Passivation Layers on GaN 显示文摘 | Hlad M Voss L Gila B P etal | 2006 | Appl Surf Sci2006，252，22： | 1 |
| 10 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 1 |
| 11 | Biomass gasification in atmospheric and bubbling fluidized bed:Effect of thetype of gasifying agent on the product distribution显示文摘 | GILA J CORELLA J AZNAR M P CABALLEROA M A | 1999 | Biomass Bioenergy1999，17，5： | 1 |
| 12 | Determination of MgO/GaN Heterojunction Band Offsets by X-Ray Photoelectron Spectroscopy 显示文摘 | Chen J J Gila B P Hlad M | 2006 | Applied Physics Letters2006，88，04： | 1 |
| 13 | Hepatitis C virus NS5A region mutation in chronic hepatitis C genotype 1 patients who are non-responders to two or more treatments and its relationship with response to a new treatment显示文摘AIM To determine the number of mutations in the NS5 A region of the hepatitis C virus(HCV) and its relationship to the response to antiviral therapy in patients with chronic hepatitis C genotype 1 who are non-responders to two or more treatments. METHODS Sequences within HCV NS5 A [PKR binding domain(PKRBD) and the interferon-sensitivity-determining region(ISDR)] were analysed via direct sequencing in a selected cohort of 72 patients, with a total of 201 treatments [interferon-alpha(IFN-α), n = 49; IFN-α + ribavirin(RBV), n = 75; pegylated(peg) IFN-α + RBV, n = 47; first-generation direct-acting antivirals(DAAs), n = 13; and second-generation DAAs, n = 17]. Of these, 48/201 achieved a sustained virological response(SVR) and 153/201 achieved no virological response(NVR).RESULTS For both regions, treatments resulting in SVR were associated with more baseline mutations than were treatments resulting in NVR(SVR vs NVR; PKRBD: 5.82 ± 3 vs 4.86 ± 2 mutations, P = 0.045; ISDR: 2.65 ± 2 vs 1.51 ± 1.7 mutations, P = 0.005). A decrease or no change in the number of mutations over time between treatments in the PKRBD or ISDR, as shown by sequencing, was associated with patients who usually failed to respond to treatment(PKRBD, P = 0.02; ISDR, P = 0.001). Moreover, patients showing a post-treatment baseline viral load > 600000 IU/m L and increased ISDR mutations with respect to the previous treatment were 9.21 times more likely to achieve SVR(P = 0.001). CONCLUSION The obtained results show that among patients who have shown no response to two or more antiviral treatments, the likelihood of achieving SVR increases with the genetic variability in the ISDR region(≥ 2 mutations or number of substitutions from the HCV-J and HCV-1 prototype), especially when the viral load is greater than 600000 IU/m L. | Paloma Munoz de Rueda José Manuel Fuentes RodríguezRosa Quiles Pérez Ana Gila Medina Ana Belén Martínálvarez Jorge Casado Ruíz ángeles Ruíz Extremera Javier Salmerón | 2017 | World Journal of Gastroenterology2017，23，25： | 0 |
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