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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Associations of sense of coherence with psychological distress and quality of life in inflammatory bowel disease显示文摘AIM:To investigate the relationship between sense of coherence,psychological distress and health related quality of life in inflammatory bowel disease(IBD).METHODS:This cross-sectional study enrolled a consecutive sample of 147 IBD(aged 45.1 ± 14.1 years; 57.1% female) patients recruited from a tertiary gastroenterology service.Sixty-four participants met diagnostic criteria for Crohn's disease,while eightythree patients had ulcerative colitis.Socio-demographic data(education,age,race,gender,gross monthly income and marital status),disease-related variables(illness activity,relapse rate in past 2 years,history of surgery and time since diagnosis),sense of coherence(Antonovsky's SOC scale),psychological distress symptoms(Hospital Anxiety and Depression Scale) and health-related quality of life(HRQo L; WHOQOLBref) were assessed.Hierarchical multiple regression analyses were performed to identify factors that are independently associated with psychological distress and HRQo L in patients with IBD and to provide indications for possible moderating or mediating effects.In addition,formal moderation and mediation analyses(Sobel tests) were performed to confirm potential moderators/mediators of the relationship between SOC,psychological distress symptoms and HRQoL.RESULTS:Lower SOC scores(std beta=-0.504; P < 0.001),female gender(std beta = 0.176; P = 0.021) and White race(std beta = 0.164; P = 0.033) were independently associated with higher levels of depressive symptoms,while lower levels of SOC(std beta =-0.438; P < 0.001) and higher relapse rate(std beta = 0.161; P = 0.033) were independently associated with more severe anxiety symptoms.A significant interaction between time since diagnosis and SOC was found with regard to the severity of depressive or anxiety symptoms,as the interaction term(time since diagnosis X SOC) had beta coefficients of-0.191(P = 0.009) and-0.172(P = 0.026),respectively.Lower levels of anxiety symptoms(std beta =-0.369; P < 0.001),higher levels of SOC(std beta = 0.231; P = 0.016) and non-White race(std beta =-0.229; P = 0.006),i.e.,mixed-race,which represented the reference category,were independently associated with higher levels of overall HRQoL.Anxiety symptoms were the most potent independent correlate of most aspects of HRQoL.In addition,anxiety mediated the association between SOC and satisfaction with health,as well as its relationship with physical,mental,and social relations HRQo L.Depressive symptoms also mediated the association between SOC and mental HRQoL.CONCLUSION:Our data indicated that SOC is an important construct,as it influences psychological distress and has significant albeit indirect effects on several HRQoL domains in IBD. | Thiago H Freitas Elias Andreoulakis Gilberto S Alves Hesley LL Miranda Lúcia LBC Braga Thomas Hyphantis André F Carvalho | 2015 | World Journal of Gastroenterology2015，21，21： | 10 |
| 3 | Role of the HLA-DQ locus in the development of chronic gastritis and gastric carcinoma in Mexican patients显示文摘AIM: To determine the HLA-DQ locus in Mexican patients with Chronic gastritis and gastric adenocarcinoma. METHODS: Oligotyping for HLA-DQ locus was performed in 45 Mexican patients with chronic gastritis and 13 Mexican patients with diffuse-type gastric adenocarcinoma, and was then compared with 99 clinically healthy unrelated individuals. H pylori infection and CagA status were assessed in patients by enzyme-linked immunosor-bent assay (ELISA) method. RESULTS: We found a significant increased frequency of HLA-DQB1*0401 allele in H pylori-positive patients with chronic gastritis when compared with healthy subjects [19 vs 0%, P= 1 × 10-7, odds ratio (OR) = 4.96; 95% confidence interval (95% CI), 3.87-6.35]. We also found a significant increased frequency of HLA-DQB1*0501 in patients with diffuse-type gastric carcinoma in comparison with healthy individuals (P = 1 × 10-6, OR = 13.07; 95% CI, 2.82-85.14). CONCLUSION: HLA-DQ locus may play a different role in the development of H pylori-related chronic gastritis and diffuse-type gastric adenocarcinoma in the Mexican Mestizo population. | Roberto Herrera-Goepfert Jesús K Yamamoto-Furusho Luis F Oate-Ocaa Margarita Camorlinga-Ponce Leopoldo Muoz Jorge A Ruiz-Morales Gilberto Vargas-Alarcón Julio Granados Cellular Biology Section | 2006 | World Journal of Gastroenterology2006，12，48： | 4 |
| 4 | Reliability-based comparative study for mooring lines design criteria显示文摘 | Alberto Omar Vazquez-Hernandez Gilberto Bruno Ellwanger Luís Volnei Sudati Sagrilo | 2007 | Applied Ocean Research2007，，6： | 2 |
| 5 | First report of CTX-M producing Escherichia coli , including the new ST2526, isolated from beef cattle and sheep in Portugal显示文摘 | Sónia Ramos Gilberto Igrejas Nuno Silva Daniela Jones-Dias José-Luís Capelo-Martinez Manuela Cani?a Patrícia Poeta | 2013 | Food Control2013，，1： | 1 |
| 6 | The main benefits associated with health and safety management systems certification in Portuguese small and medium enterprises post quality management system certification 显示文摘 | Gilberto Santos S i ria Barros Fatima Mendes Nuno Lopes | 2013 | Safety Science2013，，51： | 1 |
| 7 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 8 | Specific adsorption of propiconazole and humic acid on Pt and PtO films显示文摘 | Andreia P S Sandra S M Gilberto M | 2009 | Electrochimica Acta2009，54，： | 1 |
| 9 | Cellulose whiskers versus microfibrils:Influence of the nature of the nanoparticle and its surface functionalization on the thermal and mechanical properties of nanocomposites显示文摘 | Gilberto S Julien B Alain D | | 0，，02： | 1 |
| 10 | Predation potential and biology of Protogamasellopsis posnaniensis Wisniewski & Hirschmann (Acari:Rhodacaridae)显示文摘 | Raphael C Castilho Moraes Gilberto J de Silva Edmilson S | 2009 | Biological Control2009，48，： | 1 |
| 11 | Fast Hybrid Simulation with Geographically Distributed Substructures显示文摘 | GILBERTO M BOZIDAR S JASON H | 2005 | Advances in Experimental Structural Engineering2005，18，1： | 1 |
| 12 | Potential toxicity of toluene and xylene evoked by mitochondrial uncoupling显示文摘 | ANDRES S R CEZAR R P GILBERTO L P | 2007 | Toxicology in Vitro2007，21，： | 1 |
| 13 | Marine organisms as a source of new anticancer agents 显示文摘 | Gilberto S da Rocha AB Robert GS | 2001 | Oncol2001，2，： | 1 |
| 14 | Hydrogen distribution network optimization:a refinery case study显示文摘 | Fonseca André Sá Ví tor Bento Hugo Tavares Manuel L C Pinto Gilberto Gomes Luí sa A C N | 2008 | Journal of Cleaner Production2008，16，16： | 1 |
| 15 | Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models 显示文摘 | ANA F GILBERTO A PATRICIO S | 2013 | Epilepsy Res2013，107，12： | 1 |
| 16 | Significance of Large Vessel Intracranial Occlusion Causing Acute Ischemic Stroke and TIA显示文摘 | Wade S. Smith Michael H. Lev Joey D. English Erica C. Camargo Maggie Chou S Claiborne Johnston Gilberto Gonzalez Pamela W. Schaefer William P. Dillon Walter J. Koroshetz Karen L. Furie | 2009 | Stroke2009，，： | 1 |
| 17 | Plant glycine-rich protein:a family or just protein with a common motif?显示文摘 | Gilberto S M Luciana O Franco | 2000 | Biochimica et Biophysica Acta2000，1492，： | 1 |
| 18 | Eect of drying method and length ofstorage on tannin and total phenol concentrations in Pigeon pea seeds 显示文摘 | EDILENE C F ANA RITA A N GILBERTO B S | 2004 | Food Chemistry2004，86，： | 1 |
| 19 | Mobilization and r-ecovery of energy stores in trai′ra,Hoplias malabaricus bloch(Teleostei,Erythrinidae)during long-term starvation and after re-feeding显示文摘 | Flavia S R Gilberto M Eliane T O | 2006 | Comp Physiol B2006，176，： | 1 |
| 20 | Interleukin 1 β (IL-1B) and IL-1 Antagonist Receptor (IL-1RN) Gene Polymorphisms are Associated With the Genetic Susceptibility and Steroid Dependence in Patients With Ulcerative Colitis显示文摘 | Jesús K. Yamamoto-Furusho Jean J. Santiago-Hernández Nonanzit Pérez-Hernández Silvestre Rami′rez-Fuentes José Manuel Fragoso Gilberto Vargas-Alarcón | 2011 | Journal of Clinical Gastroenterology2011，，6： | 1 |
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