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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Effect of immediate postoperative enteral nutrition on body composition, muscle function, and wound healing显示文摘 | Schroeder D Gillanders L Mahr K | 1991 | JPEN1991，15，4： | 1 |
| 3 | Functionalization of single-walled carbon nanotubes using isotropic plasma treatment: Resonant Raman spectroscopy study 显示文摘 | Utegulov Z N Mast D B He P Shi D L and Gilland R F | 2005 | J Appl Phys2005，97，： | 1 |
| 4 | Effects of immediate postoperative enteral nutrition on body composition,muscle functionand wound healing显示文摘 | Schroeder D Gillanders L Mahr K | 1991 | J PEN1991，12，： | 1 |
| 5 | Deconjugation of bile acids by intestinal lactobiUus 显示文摘 | Gilland S E Speck M L | 1977 | Applied Environmental Microbiology1977，33，： | 1 |
| 6 | Effect of immediate postoperative enteral nutrition on body composition,muscle fenction and wound healing显示文摘 | Schroeder D1 Gillanders L Mahr K | 1991 | JPEN1991，15，4： | 1 |
| 7 | Chemokine and inflammatory cell response tohypoxia-ischemia in immature rats显示文摘 | Bona E Andensson A L Blomqren K Gilland E Puka-SundvallM Gustafson K | 1999 | Pediatr Res1999，45，41： | 1 |
| 8 | Effects of immediate postoperative enteral nutrition on body composition, muscle function, and wound healing显示文摘 | Schroeder D Gillanders L Mahr K | 1991 | JPEN J Parenter Enteral Nutr1991，15，4： | 1 |
| 9 | Mitochondrial function and energy metabolism after hypoxia-ischemia in the imma- ture rat brain: involvement of NMDA-receptors 显示文摘 | Gilland E Puka-Sundvall M HiUered L | 1998 | J Cereb Blood Flow Metab1998，18，3： | 1 |
| 10 | Amphioxus and the evolution of head segmentation显示文摘 | Holland L Z Holland N D Gilland E | 2008 | Integrative and Comparative Biology2008，48，5： | 1 |
| 11 | Sentinel lymph node biopsy in patients with multicentric/muhifocal breast cancer: low false-negative rate and lack of axillary recurrence 显示文摘 | Holwitt D M Gillanders W E Aft R L | 2008 | Am J Surg2008，1964，： | 1 |
| 12 | Mitochondrial function and energy metabolism after hypoxia-ischemia in the immature rat brain: involvement of NMDA-receptors显示文摘 | Gilland E Puka-Sundvall M Hillered L | 1998 | J Cereb Blood Flow Metab1998，18，： | 1 |
| 13 | A prospective study of catheter-related complications in HPN patients显示文摘 | Gillanders L Angstmann K Ball P | 2012 | Clin Nutr2012，31，1： | 1 |
| 14 | Effect s of im- mediate postoperative enteraI nut rition on body eomposi tion,muscle function,and wound healing 显示文摘 | Schroeder D Gillanders L Mahr K | 1991 | Jpen J Par- enter Enteral Nutr1991，15，4： | 1 |
| 15 | Effects of inmmdiate postoperative enteral nutrition on body composition, muscle function, and wound healing显示文摘 | Schroeder D Gillanders L Mahr K | 1991 | JPEN1991，15，3： | 1 |
| 16 | Deconjugation of bile acids by intestinal lactobacilli显示文摘 | GILLAND S E SPECK M L | 1977 | Appl Environ Mierob1977，33，1： | 1 |
| 17 | Effects of immediate postoperative enteral nutrition on body composition, muscle function,and wound healing显示文摘 | SCHROEDER D GILLANDERS L MAHR K | 1991 | JPN J Parenter Enteral Nutr1991，15，4： | 1 |
| 18 | Effects of immediate postoperative enteral nutrition on body composition,muscle function and wound healing显示文摘 | Schroeder D Gillanders L Mahr K | 1991 | JPEN1991，15，： | 1 |
| 19 | Effects of immediate postoperative enteral nutrition on body composition,muscle function,and wound healing显示文摘 | Schroeder D Gillanders L Mahr K | 1991 | JPEN J Parenter Enteral Nutr1991，15，4： | 1 |
| 20 | Effects of immediate postoperative enteral nutrition on body composition,muscle function,and wound healing显示文摘 | Schroeder D Gillanders L Mahr K | 1991 | JPEN J Parenter Enteral Nutr1991，15，4： | 1 |
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