|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Greenhouse gas emissions from different pig manure management techniques: a critical analysis显示文摘 | Conor Dennehy Peadar G. Lawlor Yan Jiang Gillian E. Gardiner Sihuang Xie Long D Nghiem Xinmin Zhan | 2017 | Frontiers of Environmental Science & Engineering2017，11，3： | 5 |
| 2 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 3 | Reagentless pH - based biosensing using a fluorescently - labelled dextran coentrapped with a hydrolytic enzyme in solgel derived nanocomposite films显示文摘 | GULCEV M D GORING L G GILLIAN R M | 2002 | Anal Chim Acta2002，457，1： | 1 |
| 4 | Posterior retroperitoneoscopic adrenalectomy is a safe and effective alternative to transabdominal laparoscopic adrenalectomy for pheochromocytoma显示文摘 | Paxton V D Gillian C A Elibabeth G G | 2011 | J Surg2011，150，： | 1 |
| 5 | 查看详情显示文摘 | Christopher A S Rasmus H Arfa R.M Warwick B D Gillian M S Royston G Alan J D | | 0，，01： | 1 |
| 6 | Executive functions and methylphenidate response in subtypes of attention-deficit/hyperactivity disorder显示文摘 | Gillian A O'Driscoll Lana Dépatie | 2005 | Biol Psychiatry2005，57，11： | 1 |
| 7 | The effect of polysaccharides and polyacrylamides on the depression of talc and the flotation of sulphide minerals显示文摘 | Beattie D A Huynh L Gillian B N | 2006 | Minerals Engineering2006，19，68： | 1 |
| 8 | Genetic diversity of the biofilm covering Montacuta ferruginosa(Mollusca, Bivalvia) as evaluated by denaturing gradient gel electrophoresis analysis and cloning of PCR amplified gene fragment coding for 16S rDNA显示文摘 | Gillian D C Speksnijder A G C L Zwart G | 1998 | Applied and Environmental Microbioloxy1998，64，9： | 1 |
| 9 | Frequency control in competitive electricity market dispatch显示文摘 | Ronan D Gillian L Malley M O | 2005 | IEEE Transactions on Power Systems2005，20，3： | 1 |
| 10 | Frequency control in competitive electricity market dispatch显示文摘 | RONAN D GILLIAN L MALLEY M O | 2005 | IEEE Transactions on Power Systems2005，20，3： | 1 |
| 11 | Genetic diversity of the biofilm covering Montacuta ferruginosa ( Mollusca, Bivalvia ) as evaluated by denaturing gradient gel electrophoresis analysis and cloning of PCR amplified gene fragment coding for 16S rDNA显示文摘 | Gillian D Speksnijder A G C L Zwart G J M | 1998 | Applied and Environmental Microbiology1998，64，9： | 1 |
| 12 | Organochlorine pesticides in the soils and atmosphere of Costa Riea显示文摘 | Gillian L D Ying D L Camilla T el al | 2007 | Environment Science and Technology2007，41，： | 1 |
| 13 | Quantifying the effects of past soil erosion on present productivity 显示文摘 | Daniels R B Gillian J W Cassel D K and Nelson L A | 1987 | J Soil and Water Conserv1987，42，： | 1 |
| 14 | A Cross-Country Comparison of Rivaroxaban Spontaneous Adverse Event Reports and Concomitant Medicine Use with the Potential to Increase the Risk of Harm显示文摘 | McDonald Cameron J Kalisch Ellett Lisa M Barratt John D Caughey Gillian E | 2014 | Drug Safety2014，，12： | 1 |
| 15 | Cloning of a differentially expressed tropomyosin isoform from cultured rabbit aortic smooth muscle cells显示文摘 | Adeed A Girjes D K Gillian W C | 2002 | IJBCB2002，34，： | 1 |
| 16 | A novel mouse beta defensin,Defb2,which is upregulated in the airways by lipopolysaccharide显示文摘 | GILLIAN M M DONALD J D JuLIA R D | 1999 | Federation of European Biochemical Societies1999，442，1： | 1 |
| 17 | modulation of tumor angiogenesis by conditional expression of fibroblast growth factor- 2 affects early but not established tumors 显示文摘 | Guavas MP Gillian IR Coltrane D | 2001 | Cancer Res2001，61，1： | 1 |
| 18 | The effect of polysaccharides and polyacrylamides on the depression of talc and the flotation of sulphide minerals显示文摘 | Beattie D A Huynh L Gillian B N | 2006 | Mir_erals Engineering2006，19，68： | 1 |
| 19 | The effect of polysaccharides and polyacrylamides on the depression of talc and theotation of sulphide minerals显示文摘 | BEATTIE D A HUYNH L GILLIAN B N | 2006 | Minerals Engineering2006，19，68： | 1 |
| 20 | Blonanserin: A review of its use in the management of schizophrenia显示文摘 | EMMA D GILLIAN M | 2010 | CNS Drugs2010，24，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员