|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Familial aggregation in inflammatory bowel disease:Is it genes or environment?显示文摘Inflammatory bowel disease (IBD) develops in genetically susceptible individuals due to the influence of environmental factors, leading to an abnormal recognition of microbiota antigens by the innate immune system which triggers an exaggerated immune response and subsequent bowel tissue damage. IBD has been more frequently found in families, an observation that could be due to either genetic, environmental or both types of factors present in these families. In addition to expanding our knowledge on IBD pathogenesis, defining the specific contribution to familial IBD of each one of these factors might have also clinical usefulness. We review the available evidence on familial IBD pathogenesis. | Tiago Nunes Gionata Fiorino Silvio Danese Miquel Sans | 2011 | World Journal of Gastroenterology2011，17，22： | 9 |
| 2 | Narrow-band imaging endoscopy to assess mucosal angiogenesis in inflammatory bowel disease: A pilot study显示文摘AIM: To investigate whether narrow band imaging (NBI) is a useful tool for the in vivo detection of angiogenesis in inflammatory bowel disease (IBD) patients. METHODS: Conventional and NBI colonoscopy was performed in 14 patients with colonic inflammation (8 ulcerative colitis and 6 Crohn’s disease). Biopsy samples were taken and CD31 expression was assayed immuno- histochemically; microvascular density was assessed by vessel count. RESULTS: In areas that were endoscopically normal but positive on NBI, there was a significant (P < 0.05) increase in angiogenesis (12 ± 1 vessels/field vs 18 ± 2 vessels/field) compared with areas negative on NBI. In addition, in areas that were inflamed on white light endoscopy and positive on NBI, there was a significant (P < 0.01) increase in vessel density (24 ± 7 vessels/f ield) compared with NBI-negative areas.CONCLUSION: NBI may allow in vivo imaging of intestinal angiogenesis in IBD patients. | Silvio Danese Gionata Fiorino Erika Angelucci Stefania Vetrano Nico Pagano Giacomo Rando Antonino Spinelli Alberto Malesci Alessandro Repici | 2010 | World Journal of Gastroenterology2010，16，19： | 9 |
| 3 | Calcium supplementation for the prevention of colorectal adenomas: a systematic review and meta-analysis of randomized controlled trials显示文摘AIM: To determine the efficacy of calcium supplementation in reducing the recurrence of colorectal adenomas.METHODS: We conducted a systematic review and meta-analysis of published studies. We searched Pub Med, Scopus, the Cochrane Library, the WHO International Clinical Trials Registry Platform, and the Clinical Trials.gov website, through December 2015. Randomized, placebo-controlled trials assessing supplemental calcium intake for the prevention of recurrence of adenomas were eligible for inclusion. Two reviewers independently selected studies based on predefined criteria, extracted data and outcomes(recurrence of colorectal adenomas, and advanced or 'high-risk' adenomas), and rated each trial's riskof-bias. Between-study heterogeneity was assessed, and pooled risk ratio(RR) estimates with their 95% confidence intervals(95%CI) were calculated using fixed- and random-effects models. To express the treatment effect in clinical terms, we calculated the number needed to treat(NNT) to prevent one adenoma recurrence. We also assessed the quality of evidence using GRADE.RESULTS: Four randomized, placebo-controlled trials met the eligibility criteria and were included. Daily doses of elemental calcium ranged from 1200 to 2000 mg, while the duration of treatment and follow-up of participants ranged from 36 to 60 mo. Synthesis of intention-to-treat data, for participants who had undergone follow-up colonoscopies, indicated a modest protective effect of calcium in prevention of adenomas(fixed-effects, RR = 0.89, 95%CI: 0.82-0.96; randomeffects, RR = 0.87, 95%CI: 0.77-0.98; high quality of evidence). The NNT was 20(95%CI: 12-61) to prevent one colorectal adenoma recurrence within a period of 3 to 5 years. On the other hand, the association between calcium treatment and advanced adenomas did not reach statistical significance(fixed-effects, RR = 0.92, 95%CI: 0.75-1.13; random-effects, RR = 0.92, 95%CI: 0.71-1.18; moderate quality of evidence). CONCLUSION: Our results suggest a modest chemopreventive effect of calcium supplements against recurrent colorectal adenomas over a period of 36 to 60 mo. Further research is warranted. | Stefanos Bonovas Gionata Fiorino Theodore Lytras Alberto Malesci Silvio Danese | 2016 | World Journal of Gastroenterology2016，22，18： | 6 |
| 4 | Risk of postoperative recurrence and postoperative management of Crohn's disease显示文摘Crohn's disease (CD) is a chronic inflammatory disease of the digestive tract with systemic manifestations. Etiology is unknown, even if immunological, genetic and environmental factors are involved. The majority of CD patients require surgery during their lifetime due to progressive bowel damage, but, even when all macroscopic lesions have been removed by surgery, the disease recurs in most cases. Postoperative management represents therefore a crucial mean for preventing recurrence. Several drugs and approaches have been proposed to achieve this aim. Endoscopic inspection of the ileocolic anastomosis within 1 year from surgery is widely encouraged, given that endoscopic recurrence is one of the greatest predictors for clinical recurrence. A strategy should be planned only after stratifying patients according to their individual risk of recurrence, avoiding unnecessary therapies when possible benefits are reduced, and selecting high-risk patients for more aggressive intervention. | Antonino Spinelli Matteo Sacchi Gionata Fiorino Silvio Danese Marco Montorsi | 2011 | World Journal of Gastroenterology2011，17，27： | 4 |
| 5 | AHP-based evaluation of CMMS software 显示文摘 | Marcello B Gionata C Marco F Andrea G | 2006 | Journal of Manufacturing Technology Management2006，17，5： | 1 |
| 6 | AHP-based evaluation of CMMS software显示文摘 | Braglia Marcello Carmignani Gionata Frosolini Marco | 2006 | Journal of Manufacturing Technology Management2006，17，5： | 1 |
| 7 | New and experimental treatments of vitiligo and other hypomelanoses显示文摘 | Torello L Francesca P Gionata B | 2007 | Dermatol Clinic2007，25，： | 1 |
| 8 | Viral infections in inflammatory bowel disease:Tips and tricks for correct management显示文摘Over the past decades,the treatment of inflammatory bowel diseases(IBD)has become more targeted,anticipating the use of immune-modifying therapies at an earlier stage.This top-down approach has been correlated with favorable short and long-term outcomes,but it has also brought with it concerns regarding potential infectious complications.This large IBD population treated with immunemodifying therapies,especially if combined,has an increased risk of severe infections,including opportunistic infections that are sustained by viral,bacterial,parasitic,and fungal agents.Viral infections have emerged as a focal safety concern in patients with IBD,representing a challenge for the clinician:they are often difficult to diagnose and are associated with significant morbidity and mortality.The first step is to improve effective preventive strategies,such as applying vaccination protocols,adopt adequate prophylaxis and educate patients about potential risk factors.Since viral infections in immunosuppressed patients may present atypical signs and symptoms,the challenges for the gastroenterologist are to suspect,recognize and diagnose such complications.Appropriate treatment of common viral infections allows us to minimize their impact on disease outcomes and patients’lives.This practical review supports this standard of care to improve knowledge in this subject area. | Vincenzo Craviotto Federica Furfaro Laura Loy Alessandra Zilli Laurent Peyrin-Biroulet Gionata Fiorino Silvio Danese Mariangela Allocca | 2021 | World Journal of Gastroenterology2021，27，27： | 1 |
| 9 | Urban sprawl and land abandonment affect the functional response traits of maize weed communities in a heterogeneous landscape显示文摘 | Stefano Carlesi Gionata Bocci Anna-Camilla Moonen Paolo Frumento Paolo Bàrberi | 2013 | Agriculture, Ecosystems and Environment2013，，： | 1 |
| 10 | Supply chain and quality management显示文摘 | GIONATA C | 2009 | Business Process Management Journal2009，15，3： | 1 |
| 11 | Role of bowel ultrasound as a predictor of surgical recurrence of Crohn’s disease显示文摘 | Teresa Cammarota Davide Giuseppe Ribaldone Andrea Resegotti Alessandro Repici Silvio Danese Gionata Fiorino Antonino Sarno Daniela Robotti Paola Debani Giovanni Bonenti Rinaldo Pellicano Alida Andrealli Nicoletta Sapone Daniele Simondi Francesca Bresso Ma | 2013 | Scandinavian Journal of Gastroenterology2013，，5： | 1 |
| 12 | An integrated structu-ral framework to cost-based FMECA:The priority-cost FMECA显示文摘 | Gionata Carmignani | | 0，，94： | 1 |
| 13 | Dose optimization is effective in ulcerative colitis patients losing response to infliximab: A collaborative multicentre retrospective study显示文摘 | Monica Cesarini Konstantinos Katsanos Konstantinos Papamichael Pierre Ellul Peter L. Lakatos Flavio Caprioli Uri Kopylov Epameinondas Tsianos Gerassimos J. Mantzaris Shomron Ben-Horin Silvio Danese Gionata Fiorino | 2013 | Digestive and Liver Disease2013，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员