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| 1 | H pylori and host interactions that influence pathogenesis显示文摘H pylori is probably the most prevalent human patho- gen worldwide. Since it was initially suggested in 1983 by Marshall and Warren to be implicated in gastritis and peptic ulcer disease, H pylori has also been implicated in gastric carcinoma and was classified as a class I car- cinogen. In the last two decades, a noteworthy body of research has revealed the multiple processes that this gram negative bacterium activates to cause gastroduo- denal disease in humans. Most infections are acquired early in life and may persist for the life of the individual. While infected individuals mount an inflammatory re- sponse that becomes chronic, along with a detectable adaptive immune response, these responses are ineffec- tive in clearing the infection. H pylori has unique features that allow it to reside within the harsh conditions of the gastric environment, and also to evade the host immune response. In this review, we discuss the various virulence factors expressed by this bacterium and how they inter- act with the host epithelium to influence pathogenesis. | Ellen J Beswick Giovanni Suarez Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，35： | 20 |
| 2 | H pylori receptor MHC classⅡcontributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC classⅡin the modulation of gastric epithelial cell apoptosis induced by H pylon infection. METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specific for MHC classⅡand CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a fluorometric assay, a cytometric bead array, and confocal microscopy, respectively. RESULTS: Pretreatment of N87 cells with the anti-MHC classⅡIgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class n resulted in markedly reduced caspase activation, while simple ligation of MHC classⅡdid not. Crosslinking of MHC class n also resulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC classⅡIgM blocked the recruitment of FADD to the cell surface. CONCLUSION: The ability of MHC class n to modulate gastric epithelial apoptosis is at least partially dependent on its crosslinking. The crosslinking of this molecule has anti-apoptotic effects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC classⅡto modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 3 | H pylori receptor MHC class Ⅱ contributes to the dynamic gastric epithelial apoptotic response显示文摘AIM: To investigate the role of MHC class Ⅱ in the modulation of gastric epithelial cell apoptosis induced by H pylori infection.METHODS: After stimulating a human gastric epithelial cell line with bacteria or agonist antibodies specifi c for MHC class Ⅱ and CD95, the quantitation of apoptotic and anti-apoptotic events, including caspase activation, BCL-2 activation, and FADD recruitment, was performed with a ? uorometric assay, a cytometric bead array, and confocal microscopy, respectively.RESULTS: Pretreatment of N87 cells with the anti-MHC class Ⅱ IgM antibody RFD1 resulted in a reduction in global caspase activation at 24 h of H pylori infection. When caspase 3 activation was specifically measured, crosslinking of MHC class Ⅱ resulted in a marked re-duced caspase activation, while simple ligation of MHC class Ⅱ did not. Crosslinking of MHC class Ⅱ also re-sulted in an increased activation of the anti-apoptosis molecule BCL-2 compared to simple ligation. Confocal microscope analysis demonstrated that the pretreatment of gastric epithelial cells with a crosslinking anti-MHC class Ⅱ IgM blocked the recruitment of FADD to the cell surface.CONCLUSION: The results presented here demonstrate that the ability of MHC class Ⅱ to modulate gastric epi-thelial apoptosis is at least partially dependent on its crosslinking. Furthermore, while previous research has demonstrated that MHC class Ⅱ signaling can be pro-apoptotic during extended ligation, we have shown that the crosslinking of this molecule has anti-apoptotic ef-fects during the earlier time points of H pylori infection. This effect is possibly mediated by the ability of MHC class Ⅱ to modulate the activation of the pro-apoptotic receptor Fas by blocking the recruitment of the accessory molecule FADD, and this delay in apoptosis induction could allow for prolonged cytokine secretion by H pylori-infected gastric epithelial cells. | David A Bland Giovanni Suarez Ellen J Beswick Johanna C Sierra Victor E Reyes | 2006 | World Journal of Gastroenterology2006，12，33： | 2 |
| 4 | Timestamps in key distribution protocols 显示文摘 | DOROTHY E D GIOVANNI M S | 1981 | Communication of the ACM1981，24，8： | 1 |
| 5 | CDC25A and B dualspecificity phosphatase inhibitors : potential agents for cancer therapy 显示文摘 | Laveeehia A Di Giovanni C Novellino E | 2009 | Curr Med Chem2009，16，15： | 1 |
| 6 | A Statistical Model for L and Mobile Satellite Channels and Its Application to Nongeostationary Orbit System s显示文摘 | Giovanni E Corazza Franeesco Vatalaro | 1994 | IEEE Transon -VT1994，43，3： | 1 |
| 7 | The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina显示文摘 | San Giovanni J P Chew E Y | 2005 | Progress in Retina and Eye Research2005，24，1： | 1 |
| 8 | A GARCH Option Pricing Model with Filtered Historical Simulation 显示文摘 | GIOVANNI B ROBERT F E LORIANO M | 2008 | Review of Financial Studies2008，21，3： | 1 |
| 9 | Cdc25A and B dual-specificity phosphatase inhibitors: potential agents for cancer therapy 显示文摘 | Lavecchia A Di Giovanni C Novellino E | 2009 | Curt Med Chem2009，16，15： | 1 |
| 10 | The role of omega - 3 long- chain polyunsaturated fatty acids in health and dis- ease of the retina显示文摘 | SAN GIOVANNI J P CHEW E Y | 2005 | Prog Re Eye Res2005，24，1： | 1 |
| 11 | The let-7 microRNA represses cell proliferation pathways in human cells显示文摘 | Charles D J Aurora E K Giovanni S | 2007 | Cancer Res2007，67，17： | 1 |
| 12 | Impact of living with bipolar patients: Making sense of caregivers' burden显示文摘The aim of the present review was to examine objective and subjective burdens in primary caregivers(usually family members) of patients with bipolar disorder(BD) and to list which symptoms of the patients are considered more burdensome by the caregivers. In order to provide a critical review about caregiver's burden in patients with bipolar disorder, we performed a detailed Pub Med, Bio Med Central, ISI Web of Science, Psyc INFO, Elsevier Science Direct and Cochrane Library search to identify all papers and book chapters in English published during the period between 1963 and November 2011. The highest levels of distress were caused by the patient's behavior and the patient's role dysfunction(work, education and social relationships). Furthermore, the caregiving role compromises other social roles occupied by the caregiver, becoming part of the heavy social cost of bipolar affective disorder. There is a need to better understand caregivers' views and personal perceptions of the stresses and demands arising from caring for someone with BD in order to develop practical appropriate interventions and to improve the training of caregivers. | Maurizio Pompili Désirée Harnic Xenia Gonda Alberto Forte Giovanni Dominici Marco Innamorati Konstantinos N Fountoulakis Gianluca Serafini Leo Sher Luigi Janiri Zoltan Rihmer Mario Amore Paolo Girardi | 2014 | World Journal of Psychiatry2014，4，1： | 1 |
| 13 | Immune response to H pylori显示文摘The gastric mucosa separates the underlying tissue from the vast array of antigens that traffic through the stomach lumen. While the extreme pH of this environ- ment is essential in aiding the activation of enzymes and food digestion, it also renders the gastric epithelium free from bacterial colonization, with the exception of one important human pathogen, H pylori. This bacterium has developed mechanisms to survive the harsh environment of the stomach, actively move through the mucosal layer, attach to the epithelium, evade immune responses, and achieve persistent colonization. While a hallmark of this infection is a marked inflammatory response with the in- filtration of various immune cells into the infected gastric mucosa, the host immune response is unable to clear the infection and may actually contribute to the associ- ated pathogenesis. Here, we review the host responses involved during infection with H pylori and how they are influenced by this bacterium. ? 2006 The WJG Press. All rights reserved. | Giovanni Suarez Victor E Reyes Ellen J Beswick | 2006 | World Journal of Gastroenterology2006，12，35： | 1 |
| 14 | The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina显示文摘 | GIOVANNI J P S CHEW E Y | 2005 | Progress in Retinal and Eye Research2005，24，1： | 1 |
| 15 | Associa- tion between periodontal and peri -implant conditions: a 10 -year prospective study 显示文摘 | KAROUSSIS I K MULLER S GIOVANNI E S | 2004 | Clin Oral Implants Res2004，15，1： | 1 |
| 16 | Prenatal diagnosis of agenesis of corpus eallosum: what is the neurodevelopmental outcome? 显示文摘 | Francesco E Maria-Edgarda B Giovanni E | 2006 | Pediatr Int2006，48，3： | 1 |
| 17 | Thalidomide in myelofibrosis with myeloid metaplasia: a pooled-analysis of individual patient data from five studies显示文摘 | Giovanni B Michelle E Letizia C | 2002 | Leuk Lymphoma2002，43，12： | 1 |
| 18 | SurfaceRoughness Analysis, Modelling and Prediction in SelectiveLaser Melting显示文摘 | GIOVANNI S LIANG H RICHARD M E | 2013 | Journal of Materials Processing Technology2013，213，： | 1 |
| 19 | Changes in the chemical characteristics of water-extractable organic matter during composting and their influence on compost stability and maturity显示文摘 | Said-Pullicino D Flora G E Giovanni G | 2007 | Bioresource Technology2007，98，： | 1 |
| 20 | Performance of ring laser strap-down marine gyrocompass显示文摘 | Giovanni C S Jr Dr Levinson E | 1981 | Navigation1981，28，4： | 1 |
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