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| 1 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 2 | KIR and a specific HLA-C gene are associated with susceptibility and resistance to hepatitis B virus infection in a Brazilian population显示文摘 | Patricia Araujo Giovana Goncalves Flavia Latini Orlando Ferreira Luis Cristovao Porto Jose Augusto Barreto Manoel Joao Castelo Girao Ricardo Sobhie Diaz | 2014 | Cellular & Molecular Immunology2014，11，6： | 3 |
| 3 | Cross-correlation and sine-fitting techniques for high-resolution ultrasonic ranging显示文摘 | QUERIO R ALEGRIA F C GIRAO P S | 2010 | IEEE Transactions on Instrumentation and Measurement2010，59，12： | 1 |
| 4 | Menopausal genuine stress urinary incomtinence treated with conjugated estrogens plus progestogens显示文摘 | B aracat EC Girao BC | 1995 | Int J Gynecol Obstet1995，49，2： | 1 |
| 5 | Spread spectrum techniques in wireless communication显示文摘 | Pereira M Postolache O Girao P | 2009 | IEEE In- strumentation & Measurement Magazine2009，12，6： | 1 |
| 6 | Estrogen therapy influence onpefiurethral vessels in postmenopausal ineontinence women using Dopplerveloeimetry analysis 显示文摘 | Kobata SA Girao MJ Baracat EC | 2011 | Maturitas2011，61，3： | 1 |
| 7 | Concealed data aggregation for reverse multicast traffic in sensor networks: encryption, key distribution, and routing adaptation显示文摘 | Westhoff D Girao J and Acharya M | 2006 | IEEE Transactions on Mobile Computing2006，5，10： | 1 |
| 8 | Experimental assessment of the behavior of bolted T-stub connections made up of welded plates显示文摘 | Girao Coelho A M Bijlaard F S K Gresnigt N | 2004 | Journal of Constructional Steel Research2004，60，2： | 1 |
| 9 | Identities in the Future Internet of Things显示文摘 | SARMA A C GIRAO J | 2009 | Wireless Pers Commun2009，，49： | 1 |
| 10 | Quantitative detection of Borreliaburgdoeferi in millimeter skin samples of erythema migrans lesions:correla-tion of results with clinical and laboratory findings显示文摘 | LIVERIS D WANG G GIRAO G | 2002 | J Clin Microbiol2002，40，4： | 1 |
| 11 | Tactile sen-sors for robotic applications显示文摘 | Girao P S Ramos P M P Postolache O | | 0，，3： | 1 |
| 12 | High glucose down-regulates intercellular communication in retinal endothelial cells by enhancing degradation of connexin 43 by a proteasome-dependent mechanism显示文摘 | Fernandes R Girao H Pereira P | 2004 | J Biol Chem2004，279，27： | 1 |
| 13 | Concealed data aggrega- tion for reverse muhicast traffic in sensor networks: encryption, key distribution, and routing adaptation 显示文摘 | WESTHOFF D GIRAO J ACHARYA M | 2006 | IEEE Trans on Mobile Computing2006，5，10： | 1 |
| 14 | Effect of estrogen-progestogen hormonal replacement therapy on periurethral and bladder vessels显示文摘 | Girao BC Sartori GF | 2000 | Int Urogynecol J Pelvic Floor Dysfunct2000，11，2： | 1 |
| 15 | Concealed data aggregation for reverse multicast traffic in sensor networks: Encryption, key distribution, and routing adaptations显示文摘 | Westhoff D Girao J Acharya M | 2006 | IEEE Transactions on Mobile Computing2006，5，10： | 1 |
| 16 | A clinical trial of the effect of a mouth-rinse prepared with Lippia sidoides Cham essential oil in dogs with mild gingival disease显示文摘 | Girao VC Nunes-Pinheiro DC Morais SM | 2003 | Prev Vet Med2003，59，12： | 1 |
| 17 | Concealed data aggregation for reverse multicast traffic in sensor networks: encryption, key distri- bution, and muting adaptations 显示文摘 | WESTHOFF D GIRAO J ACHARYA M | 2006 | I EEE Trans on Mobile Com- puting2006，5，10： | 1 |
| 18 | Cholesterol may act as an antioxidant in lens membranes显示文摘 | Girao H Mota C Pereira P | 1999 | Curr Eye Res1999，18，6： | 1 |
| 19 | Effect of chromium substitution in Ca4Mn3O10 显示文摘 | Sousa P M Girao A Jorge M E M | 2004 | Journal of Physics and Chemistry of Solids2004，65，11： | 1 |
| 20 | An FFT- based method to evaluate and compensate gain and offset errors of interleaved ADC systems显示文摘 | Pereira JMD Girao PMBS Serra AMC | 2004 | IEEE Transactions on Instrumentation and Measurement2004，53，2： | 1 |
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