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| 1 | Endoscopic approach to malignant strictures at the hepatic hilum显示文摘Hilar tumors have proven to be a challenge to treat and manage because of their poor sensitivity to conventional therapies and our inability to prevent or to detect early tumor formation. Endoscopic stent drainage has been proposed as an alternative to biliary-enteric bypass surgery and percutaneous drainage to palliate malignant biliary obstruction. Prosthetic palliation of patients with malignant hilar stenoses poses particular difficulties, especially in advanced lesions (type n lesions or higher). The risk of cholangitis after contrast injection into the biliary tree in cases where incomplete drainage is achieved is well known. The success rate of plastic stent insertion is around 80% in patients with proximal tumors. Relief of symptoms can be achieved in nearly all patients successfully stented. | Giovanni D De Palma Stefania Masone Maria Rega Immacolata Simeoli Francesca Salvatori Saverio Siciliano Francesco Maione Valerio Girardi Marta Celiento Giovanni Persico | 2007 | World Journal of Gastroenterology2007，13，30： | 8 |
| 2 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 3 | Multiple orbits for Hamiltonian systems on starshaped surfaces with symmetries显示文摘 | Girardi M | 1984 | Ann Inst H Poincare Anal Non Lineaire1984，1，4： | 2 |
| 4 | Solutions of minimal period for a class of nonconvex Hamiltonian systems and applications to the fixed energy problem显示文摘 | Girardi M Matzeu M | 1986 | Nonlinear Anal TMA1986，10，4： | 2 |
| 5 | Occupational exposure to vinyl chloride and liver diseases显示文摘Portal hypertension,liver fibrosis,and angiosarcoma of the liver(ASL)have been reported among workers exposed to vinyl chloride monomer(VCM)since the 1970s.In 2007,the International Agency for Research on Cancer established the association of VCM with hepatocellular carcinoma(HCC),though only on the basis of the few cases available.Thereafter,recent reports from the United States cohort and a European sub-cohort of vinyl chloride workers provided compelling evidence of a strong association between cumulative VCM exposure and HCC risk.Further areas of research include the risk of liver cancer at lower levels of exposure and different patterns of risk of ASL and HCC with the time since exposure.The evidence of interaction between VCM exposure and other known liver carcinogens such as alcohol and chronic viral infection provides clues for the health surveillance of exposed workers.Notably,also the risk of VCM-associated chronic liver disease is modulated by alcohol consumption,viral infection,and genetic polymorphism.A counter-intuitive finding from cohort studies of exposed workers is the lower mortality from liver cirrhosis with respect to the general population;this can be attributed to the healthy worker effect and to the selection of liver cancer as the cause of death in the presence of concomitant chronic liver disease.Studies designed to overcome these intricacies confirmed an association between cumulative VCM exposure and the risk of liver cirrhosis. | Ugo Fedeli Paolo Girardi Giuseppe Mastrangelo | 2019 | World Journal of Gastroenterology2019，25，33： | 2 |
| 6 | Fifteen‐Year Experience and Outcomes of Pericardiectomy for Constrictive Pericarditis显示文摘 | Dimitrios Avgerinos Yuri Rabitnokov Berhane Worku Siyamek Neragi‐Miandoab Leonard N. Girardi | 2014 | J Card Surg2014，，4： | 2 |
| 7 | Outcome of revision discectomies following recurrent lumbar disc herniation显示文摘 | Papadopoulos EC Girardi FP Sandhu HS | 2006 | Spine2006，31，13： | 1 |
| 8 | Long-term survival and prognostic factors in thymic epithelial tumours显示文摘 | Rea F Marulli G Girardi R | 2004 | Eur J Cardiothorac Surg2004，26，2： | 1 |
| 9 | The prevalence of contraindications to total disc replacement in a cohort of lumbar surgical patients显示文摘 | Huang RC Lim MR Girardi FP | 2004 | Spine (Phila Pa 1976)2004，29，22： | 1 |
| 10 | Suicide in the epilepsies: A meta-analytic investigation of 29 cohorts 显示文摘 | Pompili M Girardi P Ruberto A | 2005 | Epilepsy Behav2005，7，2： | 1 |
| 11 | Heparin treatment in pregnancy loss : potential therapeutic benefits beyond anticoagulation显示文摘 | Girardi G | 2005 | Immunology2005，6，6： | 1 |
| 12 | No evidence for a role ofCRISPLD2 in non-syndromic cleft lip with or without cleft palate inan Italian population 显示文摘 | Girardi A Martinelli M Carinci F | 2011 | Eur J Oral Sci2011，119，1： | 1 |
| 13 | Advantages and disad-vantages of nonfusion technology in spine surgery显示文摘 | Huang RC Girardi FP Lira MR | 2005 | OrthopClinN(Am)2005，36，3： | 1 |
| 14 | Immunosurveillance and immunoregulation by gammadelta T cells显示文摘 | Girardi M | 2006 | J Invest Dermatol2006，126，： | 1 |
| 15 | Systemic Risk Measurement:Multivariate GARCH Estimation of CoVaR显示文摘 | Girardi G Ergun T | 2013 | Journal of Banking and Finance2013，37，8： | 1 |
| 16 | Using English to Retrieval Software显示文摘 | Girardi MR | 1995 | Journal of Systems and Software1995，30，： | 1 |
| 17 | Long-term survival and prognostic factors in thymic epithelial tumours显示文摘 | Rea F Marulli G Girardi R | 2004 | Eur J Cardiothorac Surg2004，26，2： | 1 |
| 18 | Personality and Psychopathological Profiles in Individuals Exposed to Mobbing显示文摘 | Girardi P Monaco E Prestigiacomo C | 2007 | Violence Victims2007，，22： | 1 |
| 19 | Complementactivation induces dysregulation of angiogenic factors andcauses fetal rejection and growth restriction显示文摘 | Girardi G Yarilin D Thurman JM | 2006 | J Exp Med2006，203，： | 1 |
| 20 | Measurement of total disc replacement radiographic range of motion:a comparison of two technlques显示文摘 | Lim MR Girardi FP Zhang K | 2005 | J Spinal Disord Tech2005，18，3： | 1 |
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