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| 1 | Prevalence of Malnutrition and Frailty in Elderly Cancer Patients and Resulting Impact on Primary Treatment Recommendations in Colorectal and Breast Cancer显示文摘Objectives To estimate the prevalence of malnutrition in elderly cancer patients and its association with frailty and primary cancer treatment recommendations in patients with the two most prevalent cancers(colorectal cancer,CRC and breast cancer,BC)in the Centre-Val de Loire region of France.Methods The entire cohort of 704 patients aged 75 years or older presenting with cancer who underwent comprehensive geriatric assessment(CGA)between 2014 and 2017 was included.Nutritional status,frailty(defined by the Balducci classification system based on CGA parameters and comorbidity),and pathological criteria were analyzed in terms of the cancer treatment recommendations suggested by geriatricians both in the whole cohort and in those with CRC and BC.Results In the whole group of 704 patients(84.3+/-4.8 years),the prevalence of malnutrition was 62.9%,and was higher in CRC than in BC patients(71.1%vs 55.4%,P<0.01).In a multivariate analysis,malnutrition and frailty(as determined by the Balducci classification system)were independently related in CRC patients(OR:7.28,95%CI,1.58~34.03;P=0.012)and were unrelated to metastasis[odds ratio(OR):1.34,95%CI,0.56~3.18;P=0.5].By contrast,malnutrition in BC patients was related exclusively to the extent of metastasis(OR:3.52,95%CI,1.50~8.24;P=0.002).It was also demonstrated that geriatricians had a greater tendency to suggest only palliative care to CRC patients presenting with malnutrition(15.4%vs 2.7%,P=0.006)than to BC patients(9.8%vs 5.4%,NS).Conclusion Malnutrition in elderly cancer patients is prevalent,especially in those with colorectal cancer,where malnutrition is frailty-related and may strongly impact on cancer treatment strategies. | Vittoria Balzano Véronique Dardaine Giraud Carine Sauger Carole Lefebvre Patrick Heitzmann Thierry Lecomtef Étienne Dorvalg | 2020 | Journal of Nutritional Oncology2020，5，4： | 2 |
| 2 | Explicit solutions for the instantaneous undrained contraction of hollow cylinders and spheres in Porous elastoplastic medium 显示文摘 | Giraud A Homand F Labiouse V | 2002 | International Journal for Numerical and Analytical Methods in Geomechanics2002，26，3： | 1 |
| 3 | The PprA-PprB two-component system activates CupE, the first non-archetypalPseudomonas aeruginosa chaperone-usher pathway system assembling fimbriae显示文摘 | Giraud C Bernard C S Calderon V Yang L Filloux A Molin S Fichant G Bordi C de Bentzmann S | 2011 | Environmental Microbiology2011，13，3： | 1 |
| 4 | EDRF/NO and endothelial functions显示文摘 | Balteaux V Giraud T | 1993 | Arch Mal Coeur Vaiss1993，86，11： | 1 |
| 5 | Phosphorylation of Ser307 in insulin receptor substrate 1 blocks interactions with the insulin receptor and inhibits insulin action显示文摘 | Agnirre V Wemer ED Giraud J | 2002 | J Biol Chem2002，277，： | 1 |
| 6 | How Sex Differences in Perceptions Inf luence Customer Satisfaction:A study of Theatre Audiences显示文摘 | Voss Zannie Giraud and Véronique Cova | 2006 | Marketing Theory2006，6，2： | 1 |
| 7 | Phosphorylation of Ser307 insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action显示文摘 | Aguirre V Werner ED Giraud | 2002 | J Biol Chem2002，277，2： | 1 |
| 8 | Excess weight risk factor for alcoholic liver disease显示文摘 | Naveau S Giraud V Borotto E | 1997 | Hepatology1997，25，1： | 1 |
| 9 | Comparative study and clinical implementation of two breathing-adapted radiotherapy techniques: dosimetric benefits for lung cancer treatment显示文摘 | Simon L Giraud P Servois V | 2006 | Cancer Radiother2006，10，67： | 1 |
| 10 | Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action 显示文摘 | Aguirre V Werner E D Giraud J | 2002 | J Biol Chem2002，277，： | 1 |
| 11 | Excess weight risk factor for alcoholic liver disease 显示文摘 | Naveau S Giraud V Borottoe | 1997 | Hepatology1997，10，25： | 1 |
| 12 | Phosphorylation of Ser307 in insulin receptor substrate 1 blocks interactions with the insulin receptor and inhibits insulin action显示文摘 | Werner ED Giraud J | 2002 | J Biol Chem2002，277，2： | 1 |
| 13 | Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action显示文摘 | Aguirre V Werner E D Giraud J Lee Y H Shoelson S E White M F | 2002 | J Biol Chem2002，277，： | 1 |
| 14 | Phosphoryla tion of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action显示文摘 | AGUIRRE V WERNER E D GIRAUD J | 2002 | J Biol Chem2002，277，： | 1 |
| 15 | Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea显示文摘 | Amselem J Cuomo C A van Kan J A Viaud M Benito E P Couloux A Coutinho P M de Vries R P Dyer PS Fillinger S Fournier E Gout L Hahn M Kohn L Lapalu N Plummer K M Pradier J M Quévillon E Sharon A Simon A ten Have A Tudzynski B Tudzynski P Wincker P Andrew M Anthouard V Beever R E Beffa R Benoit I Bouzid O Brault B Chen Z Choquer M Collémare J Cotton P Danchin E G Da Silva C Gautier A Giraud C Giraud T Gonzalez C Grossetete S Güldener U Henrissat B Howlett B J Kodira C Kretschmer M Lappartient A Leroch M Levis C Mauceli E Neuvéglise C Oeser B Pearson M Poulain J Poussereau N Quesneville H Rascle C Schumacher J Ségurens B Sexton A Silva E Sirven C Soanes D M Talbot N J Templeton M Yandava C Yarden O Zeng Q Rollins J A Lebrun M H Dickman M | 2011 | PLoS Genetics2011，7，10： | 1 |
| 16 | Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action显示文摘 | Aguirre V Werner ED Giraud J | 2002 | J Biol Chem2002，277，2： | 1 |
| 17 | Algorithm 842:a set of gmres routines for real and complex arithmetics on high performance computers显示文摘 | Frayssé V Giraud L Gratton S | 2005 | ACM Trans Math Softw2005，31，2： | 1 |
| 18 | Inhaler technique and asthma: Feasability and acceptability of training by pharmacists显示文摘 | Giraud V Allaert FA Roche N | 2011 | Respiratory Medicine2011，105，： | 1 |
| 19 | Misuse of corticosteroid metered - dose inhaler is associated with decreased asthma stability显示文摘 | Giraud V Roche N | 2002 | Eur Respir J2002，19，2： | 1 |
| 20 | Comparative study and clinical implementation of two breathing-adapted radiotherapy techniques:dosimetric benefits for lung cancer treatment显示文摘 | Giraud P Servois V | 2006 | Cancer Radiother2006，10，67： | 1 |
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