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| 1 | Molecular characterization of antimicrobial multi-drug resistance in non-typhoidal Salmonellae from chicken and clam in Mangalore, India显示文摘Salmonella enterica has been documented as one of the leading causes of salmonellosis throughout the world and is most commonly associated with the consumption of contaminated food products. Thus, this research was aimed at studying the antimicrobial susceptibility pattern and detection of quinolone resistance in Salmonella spp isolated from food of animal origin. Thirty-six Salmonella isolates comprising 8 from poultry and 28 from seafood(clams) were identified, serotyped and characterized for their antimicrobial susceptibility against 10 different antibiotics. Plasmid DNA was isolated from all the isolates by alkaline lysis, quinolone resistant non-typhoidal S. Weltevreden were examined for mutation in the DNA gyrase coding gene. Among the 36 Salmonella isolates, 20 were S. weltevreden(8 from poultry and 12 from seafood) and 16 were S. Typhimurium(from seafood). All the isolates showed multiple resistance to nalidixic acid, tetracycline, co-trimoxazole and nitrofurantoin, but, interestingly, the isolates were 100% susceptible to ampicillin, chloramphenicol and gentamicin. Resistant isolates from the study carried the genes responsible for resistance to respective antibiotics. The strain S130 isolated in the study showed single point mutation,Asp87Gly, at position 87 in quinolone resistance determining region. It revealed mutation in quinolone resistance determining region as a cause for quinolone resistance in non-typhoidal Salmonellae. The occurrence of genes accountable for plasmid mediated resistance to quinolones(viz., qnrA, qnrB and qnrS) in plasmid of non-typhoidal Salmonellae isolates provides evidence for plasmid mediated quinolone resistance. | Yemisi Olukemi Adesiji Santhosh Kogaluru Shivakumaraswamy Vijaya Kumar Deekshit Girisha Shivani Kallappa Indrani Karunasagar | 2018 | The Journal of Biomedical Research2018，32，3： | 2 |
| 2 | Prevalence of different outer membrane proteins inisolates of Aemmonas species 显示文摘 | Hushiramani R K Girisha S K Bhowmick P P | 2008 | Word J MicrobiolBiotechnol2008，24，10： | 1 |
| 3 | Synthesis of some 1,3,4-thiadiazoles carrying quinoline moiety as possible bioactive agents显示文摘 | Nayak J Girisha K S Shetty N S | 2008 | Indian J Heterocyc Chem2008，17，： | 1 |
| 4 | Outcome and determinants of mortality in 269 patients with combination anti‐tuberculosis drug‐induced liver injury显示文摘 | Harshad Devarbhavi Rajvir Singh Mallikarjun Patil Keyur Sheth Channagiri Krishnamurthy Adarsh Girisha Balaraju | 2012 | J Gastroenterol Hepatol2012，，1： | 1 |
| 5 | S252W mutation in Indian patients of Apert syndrome 显示文摘 | Girisha KM Phadke SR Khan F | 2006 | Indian Pediatr2006，43，8： | 1 |
| 6 | Decomposition and nutrient release from radiata pine ( Pinus radiata ) coarse woody debris显示文摘 | Girisha K Ganjegunte Leo M Condron Peter W Clinton Murray R Davis Nathalie Mahieu | 2003 | Forest Ecology and Management2003，，2： | 1 |
| 7 | Prevalence of different outer membrane proteins in isolates of Aeromonas species显示文摘 | Khushiramani R Girisha SK Bhowmick PP | 2008 | World J Microbiol Bioteehnol2008，24，10： | 1 |
| 8 | Cloning and expression of an outer membrane protein ompTS of Aeromonas hydrophila and study of immunogenieity in fish显示文摘 | Khushiramani R Girisha SK Karunasagar I | 2007 | Protein Expr Purif2007，51，2： | 1 |
| 9 | In vitro multiple shoot induction from excised shoot tips and nodal segment explants of- Lagerstroemia indica(L)-A medicinal cum Ornamental Shrub显示文摘 | Niranjan M H Sudarshana M S Girisha S T | | Journal of Biomedical Sciences and Researched 20，2，3： | 1 |
| 10 | Cloning and expression of an outer membrane protein ompTS of Aeromonas hy- drophila and study of immunogenicity in fish 显示文摘 | Khushiramani R Girisha S K Karunasagar I | 2007 | Protein Expres- sion and Purification2007，51，： | 1 |
| 11 | Scheduling job shop associated with multiple routings with genetic and ant colony heuristics显示文摘 | GIRISHA S JAWAHARA N | 2009 | International Journal of Production Research2009，47，14： | 1 |
| 12 | Digestive system involvement and clinical outcomes among COVID-19 patients:A retrospective cohort study from Qatar显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)caused by the severe acute respiratory syndrome coronavirus 2 virus most commonly presents with respiratory symptoms.While gastrointestinal(GI)manifestations either at presentation or during hospitalization are also common,their impact on clinical outcomes is controversial.Some studies have described worse outcomes in COVID-19 patients with GI symptoms,while others have shown either no association or a protective effect.There is a need for consistent standards to describe GI symptoms in COVID-19 patients and to assess their effect on clinical outcomes,including mortality and disease severity.AIM To investigate the prevalence of GI symptoms in hospitalized COVID-19 patients and their correlation with disease severity and clinical outcomes.METHODS We retrospectively reviewed 601 consecutive adult COVID-19 patients requiring hospitalization between May 1-15,2020.GI symptoms were recorded at admission and during hospitalization.Demographic,clinical,laboratory,and treatment data were retrieved.Clinical outcomes included all-cause mortality,disease severity at presentation,need for intensive care unit(ICU)admission,development of acute respiratory distress syndrome,and need for mechanical ventilation.Multivariate logistic regression model was used to identify independent predictors of the adverse outcomes.RESULTS The prevalence of any GI symptom at admission was 27.1%and during hospitalization was 19.8%.The most common symptoms were nausea(98 patients),diarrhea(76 patients),vomiting(73 patients),and epigastric pain or discomfort(69 patients).There was no difference in the mortality between the two groups(6.21%vs 5.5%,P=0.7).Patients with GI symptoms were more likely to have severe disease at presentation(33.13%vs 22.5%,P<0.001)and prolonged hospital stay(15 d vs 14 d,P=0.04).There was no difference in other clinical outcomes,including ICU admission,development of acute respiratory distress syndrome,or need for mechanical ventilation.Drugs associated with the development of GI symptoms during hospitalization were ribavirin(diarrhea 26.37%P<0.001,anorexia 17.58%,P=0.02),hydroxychloroquine(vomiting 28.52%,P=0.009)and lopinavir/ritonavir(nausea 32.65%P=0.049,vomiting 31.47%P=0.004,and epigastric pain 12.65%P=0.048).In the multivariate regression analysis,age>65 years was associated with increased mortality risk[odds ratio(OR)7.53,confidence interval(CI):3.09-18.29,P<0.001],ICU admission(OR:1.79,CI:1.13-2.83,P=0.012),and need for mechanical ventilation(OR:1.89,CI:1.94-2.99,P=0.007).Hypertension was an independent risk factor for ICU admission(OR:1.82,CI:1.17-2.84,P=0.008)and need for mechanical ventilation(OR:1.66,CI:1.05-2.62,P=0.028).CONCLUSION Patients with GI symptoms are more likely to have severe disease at presentation;however,mortality and disease progression is not different between the two groups. | Muhammad Umair Khan Kamran Mushtaq Deema Hussam Alsoub Phool Iqbal Fateen Ata Hammad Shabir Chaudhry Fatima Iqbal Girisha Balaraju Muna A Al Maslamani Betsy Varughese Rajvir Singh Khalid Al Ejji Saad Al Kaabi Yasser Medhat Kamel Adeel Ajwad Butt | 2021 | World Journal of Gastroenterology2021，27，46： | 1 |
| 13 | TNFR2 gene polymorphism in coronary disease显示文摘 | Sankar VH Girisha KM Gilmour A | | 0，，03： | 1 |
| 14 | Synpolydactyly and HOXDI3 polyalanine repeat: addition of 2 alanine residues is without clinical consequences显示文摘 | MalikS Girisha K Wajid M | 2007 | BMC Med Genet2007，8，1： | 1 |
| 15 | Biocontrol of pathogens in shrimp hatcheries using bacteriophages 显示文摘 | Karunasagar I Shivu M M Girisha S K | 2007 | Aquaculture2007，268，1： | 1 |
| 16 | Use ofzeolites for treating natural gas co-produced waters in Wyoming, USA 显示文摘 | ZHAO Hongting GEORGE F V GIRISHA K G | 2008 | Desalination2008，228，： | 1 |
| 17 | Synthesis andantimicrobial activities of a new series of 4-S- mercapto-acetyl-3-arylsydnones显示文摘 | Hegde J C Girisha K S Adhikari A | 2008 | Eur J MedChem2008，43，12： | 1 |
| 18 | Protective efficacy of recombinant OmpTS protein of Aeromonas hydrophila in Indian major carp显示文摘 | Khushiramani R Girisha S K Karunasagar I | 2007 | Vaccine2007，25，7： | 1 |
| 19 | Cloning and expression of an outer membrane protein ompTS of Aeromonas hydrophila and study of immunogenicity in fish显示文摘 | Khushiramani R Girisha SK Karunasagar I | 2007 | Protein Expression Puri Wcation2007，51，： | 1 |
| 20 | Novel mutation inan Indian patient with Methylmalonic Acidemia, cblA type显示文摘 | Girisha KM Shrikiran A Bidchol AM | 2012 | Indian J Hum Genet2012，18，3： | 1 |
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