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		题名	作者	年代	出处	被引量
	1	Reduced lysosomal acid lipase activity: A new marker of liver disease severity across the clinical continuum of non-alcoholic fatty liver disease?显示文摘Lysosomal acid lipase(LAL)plays a key role in intracellular lipid metabolism.Reduced LAL activity promotes increased multi-organ lysosomal cholesterol ester storage,as observed in two recessive autosomal genetic diseases,Wolman disease and Cholesterol ester storage disease.Severe liver steatosis and accelerated liver fibrosis are common features in patients with genetic LAL deficiency.By contrast,few reliable data are available on the modulation of LAL activity in vivo and on the epigenetic and metabolic factors capable of regulating its activity in subjects without homozygous mutations of the Lipase A gene.In the last few years,a less severe and non-genetic reduction of LAL activity was reported in children and adults with non-alcoholic fatty liver disease(NAFLD),suggesting a possible role of LAL reduction in the pathogenesis and progression of the disease.Patients with NAFLD show a significant,progressive reduction of LAL activity from simple steatosis to non-alcoholic steatohepatitis and cryptogenic cirrhosis.Among cirrhosis of different etiologies,those with cryptogenic cirrhosis show the most significant reductions of LAL activity.These findings suggest that the modulation of LAL activity may become a possible new therapeutic target for patients with more advanced forms of NAFLD.Moreover,the measurement of LAL activity may represent a possible new marker of disease severity in this clinical setting.	Francesco Baratta Daniele Pastori Domenico Ferro Giovanna Carluccio Giulia Tozzi Francesco Angelico Francesco Violi Maria Del Ben	2019	World Journal of Gastroenterology2019，25，30：	1
	2	Effects of levosimendan on mitochondrial function in patients with septic shock: a randomized trial显示文摘	Alessandra Torraco Rosalba Carrozzo Fiorella Piemonte Anna Pastore Giulia Tozzi Daniela Verrigni Marco Assenza Alessandra Orecchioni Annalia D’Egidio Elisa Marraffa Giovanni Landoni Enrico Bertini Andrea Morelli	2014	Biochimie2014，，：	1

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