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| 1 | CEUS and Fibroscan in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis显示文摘AIM: To determine intra-hepatic blood flow and liver stiffness in patients with non-alcoholic fatty liver disease(NAFLD) and non-alcoholic steatohepatitis (NASH) using contrast-enhanced ultrasound and fibroscan.METHODS: This prospective study included 15 patients with NAFLD, 17 patients with NASH and 16 healthy controls.In each patient, real-time ultrasound was used to locate the portal vein (PV) and the right liver lobe, and 5 mL of SonoVue? was then injected intravenous in a peripheral vein of the left arm over a 4-s span. Digital recording was performed for 3 min thereafter. The recording was subsequently retrieved to identify an area of interest in the PV area and in the right liver parenchyma(LP) to assess the blood flow by processing the data using dedicated software (Qontrast?, Bracco, Italy).The following parameters were evaluated: percentage of maximal contrast activity (Peak%), time to peak (TTP, s), regional blood volume (RBV, cm3), regional blood flow (RBF, cm3/s) and mean transit time (MTT, s).At 24-48 h post-injection, liver stiffness was evaluated using Fibroscan and measured in kPa. The statistical evaluation was performed using Student’s t test.RESULTS: In the PV, the Peak%, RBV and RBF were significantly reduced in the NAFLD and NASH patientscompared with the controls (Peak%: NAFLD 26.3 ± 6.6,NASH 28.1 ± 7.3 vs controls 55.8 ± 9.9, P < 0.001;RBV: NAFLD 4202.3 ± 3519.7, NASH 3929.8 ± 1941.3vs controls 7473 ± 3281, P < 0.01; RBF: NAFLD 32.5± 10.8, NASH 32.7 ± 12.1 vs controls 73.1 ± 13.9, P< 0.001). The TTP in the PV was longer in both patient groups but reached statistical significance only in the NASH patients compared with the controls (NASH 79.5± 37.8 vs controls 43.2 ± 30, P < 0.01). In the LP,the Peak%, RBV and RBF were significantly reduced in the NAFLD and NASH patients compared with the controls (Peak%: NAFLD 43.2 ± 7.3, NASH 41.7 ± 7.7 vs controls 56.6 ± 6.3, P < 0.001; RBV: NAFLD 4851.5± 2009, NASH 5069.4 ± 2292.5 vs controls 6922.9 ±2461.5, P < 0.05; RBF: NAFLD 55.7 ± 10.1, NASH 54.5 ± 12.1 vs controls 75.9 ± 10.5, P < 0.001). The TTP was longer in both patient groups but did not reach statistical significance. The MTT in both the PV and LP in the NAFLD and NASH patients was not different from that in the controls. Liver stiffness was significantly increased relative to the controls only in the NASH patients(NASH: 6.4 ± 2.2 vs controls 4.6 ± 1.5, P < 0.05).CONCLUSION: Blood flow derangement within the liver present not only in NASH but also in NAFLD suggests that a vascular flow alteration precedes liver fibrosis development. | Sila Cocciolillo Giustino Parruti Leonardo Marzio | 2014 | World Journal of Hepatology2014，6，7： | 7 |
| 2 | A Benefit-Risk Assessment of Ba-clofen in Severe Spinal Spasticity 显示文摘 | Alessandro D Giustino Ti | 2004 | Drug Safety2004，27，11： | 1 |
| 3 | Stable coronary artery disease: revascularisation and invasive strategies 显示文摘 | Piccolo R Giustino G Mehran R | 2015 | Lancet2015，386，： | 1 |
| 4 | Infrared Properties of Ultrathin Oxides on Si(100)显示文摘 | FELICIANO GIUSTINO ALFREDO PASQUARELLO | 2005 | Mi-croelectronic Engineering2005，80，1： | 1 |
| 5 | Seasonal changes in microbial nitrogen in an old broadleaf forest and in a neighbouring young plantation显示文摘 | Giustino Tonon Pietro Boldreghini Paola Gioacchini | 2005 | Biology and Fertility of Soils2005，，2： | 1 |
| 6 | Nutrient recycling during the decomposition of apple leaves (Malus domestica) and mowed grasses in an orchard 显示文摘 | Massimo T Giustino T Francesca S | 2007 | Agriculture Ecosystems and Environment2007，118，： | 1 |
| 7 | Duration of dual anti- platelet therapy after drug-eluting stent implantation:a system- atic review and meta-analysis of randomized controlled trials 显示文摘 | Giustino G Baber U Sartori S | 2015 | J Am Coil Cardio12015，65，： | 1 |
| 8 | Changes in polyamines, auxins and peroxidase activity during in vitro rooting of Fraxinus angustifolia shoots: an auxin -independent rooting model显示文摘 | Giustino Tonon Claire Kever Thomas Gaspar | 2001 | Tree Physiology2001，21，： | 1 |
| 9 | Ascorbic acid in ex- otic fruits: a liquid chromatographic investigation显示文摘 | GIUL1ANA V FRANCESCO R GIUSTINO M | 1995 | Food Chem- istry1995，53，： | 1 |
| 10 | 显示文摘 | Giustino O | 2001 | Pharmaeol2001，430，2： | 1 |
| 11 | Prenatal exposure to low concentrations of carbon monoxide alters habituation and non-spatial working memory in rat offspring显示文摘 | Giustino A Cagiano R Carratu MR | 1999 | Brain Research1999，844，12： | 1 |
| 12 | Consensus document on controversial issues for the treatment of infections of the central nervous system: bacterial brain abscesses显示文摘 | Massimo Arlotti Paolo Grossi Federico Pea Giustino Tomei Vincenzo Vullo Francesco G. De Rosa Giovanni Di Perri Emanuele Nicastri Francesco N. Lauria Giampiero Carosi Mauro Moroni Giuseppe Ippolito | 2010 | International Journal of Infectious Diseases2010，，： | 1 |
| 13 | Noradrenergic blockade stabilizes prefrontal activity and enables fear extinc- tion under stress显示文摘 | Fitzgerald P J Giustino T F Seemann J R | 2015 | Proc Natl Acad Sci USA2015，112，28： | 1 |
| 14 | The management of arterial and venous injury during saphenous vein surgery 显示文摘 | Giustino Marcucci Federico Accrocca Roberto Antonelli | 2007 | ICVTS2007，56，5： | 1 |
| 15 | Traumatic Intracerebellar Hemorrhage: Clinicoradiological Analysis of 81 Patients显示文摘 | Domenico d’Avella Franco Servadei Massimo Scerrati Giustino Tomei Gianluigi Brambilla Filippo F. Angileri Fulvio Massaro Luciano Cristofori Fulvio Tartara Eugenio Pozzati Roberto Delfini Francesco Tomasello | 2002 | Neurosurgery2002，，1： | 1 |
| 16 | Infrared spectra at surfaces and interfaces from first principles: e-volution of the spectra across the Si(100)-SiO2 interface显示文摘 | GIUSTINO F PASQUARELLO A | 2005 | Physical Review Letters2005，95，18： | 1 |
| 17 | Stable coronary artery disease: revascularisation and invasive strategies显示文摘 | Raffaele Piccolo Gennaro Giustino Roxana Mehran Stephan Windecker | 2015 | The Lancet . 2015 (9994)2015，，： | 1 |
| 18 | Dielectric effect of a thin SiO2 interlayer at the interface between silicon and high-k oxides 显示文摘 | Giustino F Umari P Pasquarello A | 2004 | Microelectronic Engineering2004，72，： | 1 |
| 19 | Impact of clinical presentation(stable angina pectoris vs unstable angina pectoris or Non-ST-elevation myocardial infarction vs ST-elevation myocardial infarction)on long-term outcomes in women undergoing percutaneous coronary intervention with drug-eluting stents显示文摘 | Giustino G Baber U Stefanini GG | 2015 | The American Journal of Cardiology2015，116，6： | 1 |
| 20 | Impact of clinical presentation(stable angina pectoris vs unstable angina pectoris or nonST-elevation myocardial infarction vs ST-elevation myocardial infarction)on long-term outcomes in women undergoing percutaneous coronary intervention with drug-eluting stents显示文摘 | Giustino G Baber U Stefanini GG | 2015 | Am J Cardiol2015，116，6： | 1 |
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