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| 1 | First-line endoscopic treatment with over-the-scope clips significantly improves the primary failure and rebleeding rates in high-risk gastrointestinal bleeding: A single-center experience with 100 cases显示文摘AIM To evaluate rebleeding, primary failure(PF) and mortality of patients in whom over-the-scope clips(OTSCs) were used as first-line and second-line endoscopic treatment(FLET, SLET) of upper and lower gastrointestinal bleeding(UGIB, LGIB).METHODS A retrospective analysis of a prospectively collected database identified all patients with UGIB and LGIB in a tertiary endoscopic referral center of the University of Freiburg, Germany, from 04-2012 to 05-2016(n= 93) who underwent FLET and SLET with OTSCs. The complete Rockall risk scores were calculated from patients with UGIB. The scores were categorized as < or ≥ 7 and were compared with the original Rockall data. Differences between FLET and SLET were calculated. Univariate and multivariate analysis were performed to evaluate the factors that influenced rebleeding after OTSC placement.RESULTS Primary hemostasis and clinical success of bleeding lesions(without rebleeding) was achieved in 88/100(88%) and 78/100(78%), respectively. PF was significantly lower when OTSCs were applied as FLET compared to SLET(4.9% vs 23%, P = 0.008). In multivariate analysis, patients who had OTSC placement as SLET had a significantly higher rebleeding risk compared to those who had FLET(OR 5.3; P = 0.008). Patients with Rockall risk scores ≥ 7 had a significantly higher in-hospital mortality compared to those with scores < 7(35% vs 10%, P = 0.034). No significant differences were observed in patients with scores < or ≥ 7 in rebleeding and rebleeding-associated mortality.CONCLUSION Our data show for the first time that FLET with OTSC might be the best predictor to successfully prevent rebleeding of gastrointestinal bleeding compared to SLET. The type of treatment determines the success of primary hemostasis or primary failure. | Hans-Jürgen Richter-Schrag Torben Glatz Christine Walker Andreas Fischer Robert Thimme | 2016 | World Journal of Gastroenterology2016，22，41： | 11 |
| 2 | 畜禽养殖中营养、生产环境与动物福利的关系显示文摘 | 杨玲媛 谭支良 Glatz P C | 2006 | 中国兽医学报2006，26，2： | 9 |
| 3 | Comparison of hyperthermic intraperitoneal chemotherapy regimens for treatment of peritoneal-metastasized colorectal cancer显示文摘BACKGROUND Cytoreductive surgery(CRS)in combination with hyperthermic intraperitoneal chemotherapy(HIPEC)improves patient survival in colorectal cancer(CRC)with peritoneal carcinomatosis(PC).Commonly used cytotoxic agents include mitomycin C(MMC)and oxaliplatin.Studies have reported varying results,and the evidence for the choice of the HIPEC agent and uniform procedure protocols is limited.AIM To evaluate therapeutic benefits and complications of CRS+MMC vs oxaliplatin HIPEC in patients with peritoneal metastasized CRC as well as prognostic factors.METHODS One hundred and two consecutive patients who had undergone CRS and HIPEC for CRC PC between 2007 and 2019 at the Medical Center of the University Freiburg regarding interdisciplinary cancer conference decision were retrospectively analysed.Oxaliplatin and MMC were used in 68 and 34 patients,respectively.Each patient’s demographics and tumour characteristics,operative details,postoperative complications and survival were noted.Complications were stratified and graded using Clavien/Dindo analysis.Prognostic outcome factors were identified using univariate and multivariate analysis of survival.RESULTS The two groups did not differ significantly regarding baseline characteristics.We found no difference in median overall survival between MMC and oxaliplatin HIPEC.Regarding postoperative complications,patients treated with oxaliplatin HIPEC suffered increased complications(66.2%vs 35.3%;P=0.003),particularly intestinal atony,intraabdominal infections and urinary tract infection,and had a prolonged intensive care unit stay compared to the MMC group(7.2 d vs 4.4 d;P=0.035).Regarding univariate analysis of survival,we found primary tumour factors,nodal positivity and resection margins to be of prognostic value as well as peritoneal cancer index(PCI)-score and the completeness of cytoreduction regarding peritoneal carcinomatosis.Multivariate analysis of survival confirmed primary distant metastasis and primary tumour resection status to have a significant impact on survival and likewise peritoneal cancer index-scoring regarding peritoneal carcinomatosis.CONCLUSION In this single-institution retrospective review of patients undergoing CRS with either oxaliplatin or MMC HIPEC,overall survival was not different,though oxaliplatin was associated with a higher postoperative complication rate,indicating treatment favourably with MMC.Further studies comparing HIPEC regimens would improve evidence-based decision-making. | Julia Spiegelberg Hannes Neeff Philipp Holzner Mira Runkel Stefan Fichtner-Feigl Torben Glatz | 2020 | World Journal of Gastrointestinal Oncology2020，12，8： | 3 |
| 4 | Chimeric protein probes for C5a receptors through fusion of the anaphylatoxin C5a core region with a small-molecule antagonist显示文摘Blockade of the interaction of anaphylatoxin C5a with its receptor C5aR1 has been actively studied as a potential treatment for many inflammatory diseases;but current C5a antagonists exhibit inadequate potency and poor species cross-reactivity, and novel biochemical tools are needed to investigate whether the core region of C5a contains important interaction epitopes that can explain these limitations. Herein, we report the development of chimeric protein C5a probes containing both the complete core region of rat or human C5a, and the small-molecule antagonist PMX53-1. These probes were chemically synthesized through hydrazide-based native chemical ligation of a linear peptide hydrazide with the requisite cyclopeptidic antagonist, both of which were made by solid-phase synthesis. Quasi-racemic X-ray crystallography established that attachment of PMX53-1 did not affect the structure of the core region of C5a. Subsequent C5aR1 activity assays demonstrated the probes can provide valuable insights into the development of C5a antagonists;for example, they exhibited significantly better binding affinity and much improved species cross-reactivity than PMX53-1, supporting the notion that the effect of some epitopes outside the C-terminus of C5a should be taken into consideration when designing better C5a antagonists. Surprisingly, the core region of C5a was found to partially agonize C5aR1, suggesting the presence of more than one agonistic interaction in the binding of C5a to C5aR1. This study exemplifies the value of chemical protein synthesis in developing novel receptor probes for drug discovery research. | Chao Zuo Wei-Wei Shi Xiao-Xu Chen Marie Glatz Bernd Riedl Ingo Flamme Elisabeth Pook Jiawei Wang Ge-Min Fang Donald Bierer Lei Liu | 2019 | Science China Chemistry2019，62，10： | 2 |
| 5 | Fatty acid-binding proteins asplasma marks of tissue injury显示文摘 | Pelsers MM Hermens WT Glatz JF | 2005 | Clin Chim Acta2005，352，12： | 1 |
| 6 | Synthesis de cetones a partir dacides statures et du benzene en presence de chlorure daluminium显示文摘 | Glatz A M Razus A C | 1966 | Rev Roumaine Chim1966，11，5： | 1 |
| 7 | Fatty acid-binding proteins in the heart 显示文摘 | Schaap F G van der Vusse G J Glatz J F C | 1998 | Mol Cell Biochem1998，180，12： | 1 |
| 8 | Fatty acid-binding proteins as plasma markers of tissue injury显示文摘 | Pelsers MM Hermens WT Glatz JF | | 0，，1： | 1 |
| 9 | Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses显示文摘 | Fatima Crispi Edgar Hernandez-Andrade Maurice M.A.L. Pelsers Walter Plasencia Jesus Andres Benavides-Serralde Elisenda Eixarch Ferdinand Le Noble Asif Ahmed Jan F.C. Glatz Kypros H. Nicolaides Eduard Gratacos | 2008 | American Journal of Obstetrics and Gynecology2008，，3： | 1 |
| 10 | Fatty acid-binding proteins as plasma markers of tissue injury显示文摘 | Pelsers MM Hermens WT Glatz JF | 2005 | Clin Chim Acta2005，352，12： | 1 |
| 11 | Optimization andfabrication of thick flexible polymer based microther-moelectric generator显示文摘 | Glatz W Muntwyler S Hierold C | 2006 | Sensors and A-ctuators:A2006，132，： | 1 |
| 12 | Detection of brain injury by fatty acidbinding proteins显示文摘 | Pelsers MM Glatz JF | | 0，，： | 1 |
| 13 | Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle显示文摘 | Koonen DP Glatz JF Bonen A | | 0，，： | 1 |
| 14 | Fatty acid-binding proteins as plasma markers of tissue injury 显示文摘 | PelsersMM HermensWT Glatz JF | 2005 | Clin Chim Acta2005，352，12： | 1 |
| 15 | Enzymatic Hydrolysis of Corn Gluten Meal 显示文摘 | Hardwick J E Glatz C E | 1989 | Journal of Agricultural and Food Chemistry1989，37，4： | 1 |
| 16 | Aqueous two-phase extraction for protein recovery from corn extracts显示文摘 | GLATZ C E GU Zheng-rong | 2007 | Journal of Chromatography B2007，845，： | 1 |
| 17 | Hepatoid ade- nocarcinoma with liver metastasis mimicking hepatocellular carci- noma : an and molecular study of eight cases 显示文摘 | Terracciano L M Glatz K Mhawech P Vasei M | 2003 | Am J Surg Pathol2003，27，10： | 1 |
| 18 | Membrane fatty acid trans- porters as regulators of lipid metabolism : implications for metabolic disease显示文摘 | Glatz JF Luiken J J Bonen A | 2010 | Physiol Rev2010，90，1： | 1 |
| 19 | Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal muscle显示文摘 | Koonen DP Glatz JF and Bonen A | 2005 | Biochimica et Biophysica Acta2005，1736，3： | 1 |
| 20 | Cytoplasmic fatty acid-binding protein facilitates fatty acid utilization by skeletal muscle显示文摘 | GLATZ J F C SCHAAP F G BINAS B | 2003 | Acta Physiologica Scandinavica2003，178，4： | 1 |
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