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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | γ-Glutamyltransferase activity in human atherosclerotic plaques—Biochemical similarities with the circulating enzyme显示文摘 | Maria Franzini Alessandro Corti Barbara Martinelli Antonella Del Corso Michele Emdin Giuliano F. Parenti Mattia Glauber Alfonso Pompella Aldo Paolicchi | 2008 | Atherosclerosis2008，，1： | 2 |
| 3 | Helicobacter pylori infection:How does age influence the inflammatory pattern?显示文摘The inflammatory pattern during Helicobacter pylori(H.pylori)infection is changeable and complex.During childhood,it is possible to observe a predominantly regulatory response,evidenced by high concentrations of key cytokines for the maintenance of Treg responses such as TGF-β1 and IL-10,in addition to high expression of the transcription factor FOXP3.On the other hand,there is a predominance of cytokines associated with the Th1 and Th17 responses among H.pylori-positive adults.In the last few years,the participation of the Th17 response in the gastric inflammation against H.pylori infection has been highlighted due to the high levels of TGF-β1 and IL-17 found in this infectious scenario,and growing evidence has supported a close relationship between this immune response profile and unfavorable outcomes related to the infection.Moreover,this cytokine profile might play a pivotal role in the effectiveness of anti-H.pylori vaccines.It is evident that age is one of the main factors influencing the gastric inflammatory pattern during the infection with H.pylori,and understanding the immune response against the bacterium can assist in the development of alternative prophylactic and therapeutic strategies against the infection as well as in the comprehension of the pathogenesis of the outcomes related to that microorganism. | Glauber Rocha Lima Araújo Hanna Santos Marques Maria Luísa Cordeiro Santos Filipe Antônio França daSilva Breno Bittencourt da Brito Gabriel Lima Correa Santos Fabrício Freire de Melo | 2022 | World Journal of Gastroenterology2022，28，4： | 2 |
| 4 | The quantum theory of optical coherence显示文摘 | GLAUBER R J | 1963 | Phys Rev1963，130，6： | 1 |
| 5 | The Quantum Theory of Optical Coherence 显示文摘 | GLAUBER R J | 1963 | Phys Rev1963，130，： | 1 |
| 6 | Coherent and Incoherent State of the Radiation Field 显示文摘 | GLAUBER R J | 1963 | Phys Rev1963，131，6： | 1 |
| 7 | 查看详情显示文摘 | K Cahill R Glauber | | 0，，02： | 1 |
| 8 | Anaesthetic experience with percutaneous lithotripsy显示文摘 | PETERSON GN KRIEGER JN GLAUBER DT | 1985 | Anaesthesia1985，40，5： | 1 |
| 9 | Time-Dependent Statistics of the Ising Model显示文摘 | Glauber R J | 1963 | Journal of mathematical physics1963，4，2： | 1 |
| 10 | 查看详情显示文摘 | K E Cahill R J Glauber | | 0，，05： | 1 |
| 11 | Why Hasnt Crop Insurance Eliminated Disaster Assistance? 显示文摘 | Robert Dismukes Joseph Glauber | 2005 | 34 Amber Waves Volume 3 Issue 32005，2005，： | 1 |
| 12 | The Quantum Theory of Optical Coherence显示文摘 | | 1963 | Phys Res1963，130，： | 1 |
| 13 | Multicollinearity in regression analysis:The problem revisited显示文摘 | Farrar D Glauber R | 1967 | The Review of Economic and Statistics1967，49，1： | 1 |
| 14 | High-energy scattering of protons by nuclei 显示文摘 | Glauber R J Mattiae M | 1970 | Nucl Phys1970，21，： | 1 |
| 15 | Anaesthetic experience with percutaneous lithortripey显示文摘 | Peterson GN Krieger JN Glauber DT | 1985 | Anesthesia1985，40，5： | 1 |
| 16 | New Techniques and Ideas in Quantum Measurement Theory 显示文摘 | GLAUBER R J | 1986 | Annals of the New York Academy of Sciences1986，480，1： | 1 |
| 17 | Coherent and incoherent states of the radiation field 显示文摘 | | 1963 | Phys Rev1963，131，6： | 1 |
| 18 | The quantum theory of optical coherence 显示文摘 | GLAUBER R J | 1963 | Phys Rev1963，130，： | 1 |
| 19 | Coherent and Incoherent States of the Radiation Field 显示文摘 | GLAUBER R J | 1963 | Phys Rev1963，131，： | 1 |
| 20 | Time-dependent statistics of the Ising model 显示文摘 | Glauber R J | 1963 | Journal of Mathematical Physics1963，4，2： | 1 |
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