|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw显示文摘Bacterial biofilms have emerged as potential critical triggers in the pathogenesis of bisphosphonate(BP)-related osteonecrosis of the jaw(ONJ) or BRONJ. BRONJ lesions have shown to be heavily colonized by oral bacteria, most of these difficult to cultivate and presents many clinical challenges. The purpose of this study was to characterize the bacterial diversity in BRONJ lesions and to determine host immune response. We examined tissue specimens from three cohorts(n530); patients with periodontal disease without a history of BP therapy(Control, n510), patients with periodontal disease having history of BP therapy but without ONJ(BP, n55) and patients with BRONJ(BRONJ, n515). Denaturing gradient gel electrophoresis of polymerase chain reaction(PCR)-amplified 16 S r RNA gene fragments revealed less bacterial diversity in BRONJ than BP and Control cohorts. Sequence analysis detected six phyla with predominant affiliation to Firmicutes in BRONJ(71.6%), BP(70.3%) and Control(59.1%). Significant differences(P,0.05) in genera were observed, between Control/BP, Control/BRONJ and BP/BRONJ cohorts. Enzyme-linked immunosorbent assay(ELISA)results indicated that the levels of myeloperoxidase were significantly lower, whereas interleukin-6 and tumor necrosis factor-alpha levels were moderately elevated in BRONJ patients as compared to Controls. PCR array showed significant changes in BRONJ patients with downregulation of host genes, such as nucleotide-binding oligomerization domain containing protein 2, and cathepsin G, the key modulators for antibacterial response and upregulation of secretory leukocyte protease inhibitor, proteinase 3 and conserved helix–loop–helix ubiquitous kinase. The results suggest that colonization of unique bacterial communities coupled with deficient innate immune response is likely to impact the pathogenesis of ONJ. | Smruti Pushalkar Xin Li Zoya Kurago Lalitha V Ramanathapuram Satoko Matsumura Kenneth E Fleisher Robert Glickman Wenbo Yan Yihong Li Deepak Saxena | 2014 | International Journal of Oral Science2014，6，4： | 4 |
| 2 | The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis显示文摘 | Patrick M. Smith Michael R. Howitt Nicolai Panikov Monia Michaud Carey Ann Gallini Mohammad Bohlooly-Y Jonathan N. Glickman Wendy S. Garrett | 2013 | Science . 2013 (6145)2013，，： | 3 |
| 3 | The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis显示文摘 | Patrick M. Smith Michael R. Howitt Nicolai Panikov Monia Michaud Carey Ann Gallini Mohammad Bohlooly-Y Jonathan N. Glickman Wendy S. Garrett | 2013 | 2013 (6145)2013，，6145： | 2 |
| 4 | EMR for Barrett’s esophagus–related superficial neoplasms offers better diagnostic reproducibility than mucosal biopsy 显示文摘 | Mari Mino-Kenudson Mindy J. Hull Ian Brown Alona Muzikansky Amitabh Srivastava Jonathan Glickman Do-Youn Park Lawrence Zuckerberg Joseph Misdraji Robert D. Odze Gregory Y. Lauwers | 2007 | Gastrointestinal Endoscopy2007，，： | 2 |
| 5 | The Impact of a Statewide Pre-Hospital STEMI Strategy to Bypass Hospitals Without Percutaneous Coronary Intervention Capability on Treatment Times显示文摘 | Emil L. Fosbol Christopher B. Granger James G. Jollis Lisa Monk Li Lin Barbara L. Lytle Ying Xian J. Lee Garvey Greg Mears Claire C. Corbett Eric D. Peterson Seth W. Glickman | 2013 | Circulation2013，，5： | 2 |
| 6 | 显示文摘 | Finotto S Neurath MF Glickman JN | 2002 | Science2002，295，： | 1 |
| 7 | Short' z' bunionectomy 显示文摘 | Glickman S Zahari DT | 1986 | Foot Surg1986，，25： | 1 |
| 8 | Pneumatosis intestinalis and portomesenterie venous gas in intestinal ischemia: correlation of CT findings with severity of ischemia and clinical outcome 显示文摘 | Wiesner W Mortel6 K J Glickman J N | 2001 | American Journal of Roentgenology2001，177，6： | 1 |
| 9 | Herbicide exposure and the risk of transitional cell carcrnoma of the urinary bladder in Scottish Terriers 显示文摘 | Glickman LT Raghavan M Knapp DW | 2004 | J Am Vet Med Assoc2004，，8： | 1 |
| 10 | A novel mycolic acid cycloprapane synthetase is required for coding,persistence,and virulence of Mycobacterium tuberculosis显示文摘 | Glickman MS Cox JS Jocob WR Jr | 2000 | Mol Cell2000，5，： | 1 |
| 11 | Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria 显示文摘 | Yoshida M Kobayashi K Kuo T T Bry L Glickman J N Claypool S M Kaser A Nagaishi T Higgins D E Mizoguchi E Wakatsuki Y Roopenian D C Mizoguchi A Lencer W I and Blumberg R S | 2006 | The Journal of Clinical Investigation2006，116，： | 1 |
| 12 | E- valuation of Photodynamic Therapy Using a Light-emitting Diode Lamp against Enterococcus faecalis in Extracted Hu- man Teeth 显示文摘 | Alejandro Rios Jianing He Gerald N Glickman eta/ | 2011 | Journal of Endodontics2011，37，： | 1 |
| 13 | Modulation of photochemical damage in normal and malignant cells by naturally occurring compounds显示文摘 | Lee YH Kumar NC Glickman RD | 2012 | Photoche Photobio2012，88，6： | 1 |
| 14 | 显示文摘 | Glickman JF | 1999 | Anal Biochem1999，274，11： | 1 |
| 15 | Tilmicosin antibacterial activity and pharmacokinetics in cows显示文摘 | Ziv G Shem-Tov M Glickman A | 1995 | J Vet Pharmacol Ther1995，18，5： | 1 |
| 16 | Genetic variation within a neutralizing domain on the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus 显示文摘 | Iorio R M Borgman J B Glickman R L | 1986 | J Gen Virol1986，67，： | 1 |
| 17 | Reduced plaque formation by the chloromethyl analogue of Vitamin C显示文摘 | Turesky S Gilmore ND Glickman I | 1970 | J Periodontol1970，41，： | 1 |
| 18 | The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction 显示文摘 | Glickman MH Ciechanovor A | 2002 | Physiol Rev2002，82，2： | 1 |
| 19 | Determination of voriconazole in aqueous humor by liquid chromatography-electrospray ionization-mass spectrometry显示文摘 | Zhou L Glickman RD Chen R | 2002 | J Chromatogr B Analyt Technol Biomed Life Sci2002，776，2： | 1 |
| 20 | Electromigration induced void drift andcoalescence simulations and a dynamic scaling theory显示文摘 | NATHAN M GLICKMAN E | 2000 | Appl Phys Lett2000，77，21： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员