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| 1 | Epidemiology of perforated peptic ulcer:Age-and gender-adjusted analysis of incidence and mortality显示文摘AIM:To investigate the epidemiological trends in inci-dence and mortality of perforated peptic ulcer(PPU)in a well-defined Norwegian population. METHODS:A retrospective,population-based,single-center,consecutive cohort study of all patients diag-nosed with benign perforated peptic ulcer.Included were both gastric and duodenal ulcer patients admitted to Stavanger University Hospital between January 2001 and December 2010.Ulcers with a malignant neoplasia diagnosis,verified by histology after biopsy or resection,were excluded.Patients were identified from the hospitals administrative electronic database using pertinent ICD-9 and ICD-10 codes(K25.1,K25.2,K25.5, K25.6,K26.1,K26.2,K26.5,K26.6).Additional searches using appropriate codes for relevant laparoscopic and open surgical procedures(e.g.,JDA 60,JDA 61,JDH 70 and JDH 71)were performed to enable a complete identification of all patients.Patient demographics,presentation patterns and clinical data were retrieved from hospital records and surgical notes.Crude and adjusted incidence and mortality rates were estimated by using national population demographics data. RESULTS:In the study period,a total of 172 patients with PPU were identified.The adjusted incidence rate for the overall 10-year period was 6.5 per 100 000 per year(95%CI:5.6-7.6)and the adjusted mortality rate for the overall 10-year period was 1.1 per 100 000 per year(95%CI:0.7-1.6).A non-significant decline in ad-justed incidence rate from 9.7 to 5.6 occurred during the decade.The standardized mortality ratio for the whole study period was 5.7(95%CI:3.9-8.2),while the total 30-d mortality was 16.3%.No difference in in-cidence or mortality was found between genders.However,for patients≥60 years,the incidence increased over 10-fold,and mortality more than 50-fold,compared to younger ages.The admission rates outside office hours were high with almost two out of three(63%) admissions seen at evening/night time shifts and/or during weekends.The observed seasonal variations in admissions were not statistically significant. CONCLUSION:The adjusted incidence rate,seasonal distribution and mortality rate was stable.PPU fre-quently presents outside regular work-hours.Increase in incidence and mortality occurs with older age. | Kenneth Thorsen Jon Arne Sreide Jan Terje Kvaly Tom Glomsaker Kjetil Sreide | 2013 | World Journal of Gastroenterology2013，19，3： | 14 |
| 2 | Trends in diagnosis and surgical management of patients with perforated peptic ulcer 显示文摘 | Thorsen K Glomsaker TB yon Meer A | 2011 | J Gastrointest Surg2011，15，8： | 1 |
| 3 | Patterns and predictive factors of complications after endoscopic retrograde cholangiopancreatography显示文摘 | T. Glomsaker G. Hoff J. T. Kval?y K. S?reide L. Aabakken J. A. S?reide | 2012 | Br J Surg2012，，3： | 1 |
| 4 | A symptomatic common bile duct stones显示文摘 | Rosseland AR Glomsaker TB | 2000 | Eur J Gastroenterol Hepatol2000，12，11： | 1 |
| 5 | Trends in diagnosis and surgical management of patients with perforated peptic ulcer显示文摘 | THORSEN K GLOMSAKER TB VON MEER A | 2011 | Gastrointest Surg2011，15，8： | 1 |
| 6 | Trends in diagnosis and surgical management of patients with perforated peptic ulcer显示文摘 | Thorsen K Glomsaker T B von Meer A | 2011 | J Gastrointest Surg2011，15，8： | 1 |
| 7 | Trends in diagnosis and surgical management of patients with perforated peptic ulcer显示文摘 | Thorsen K Glomsaker TB von Meer A | 2011 | J Gastrointest Surg2011，15，8： | 1 |
| 8 | Asymptomatic common bile duct stones 显示文摘 | Rosseland AR Glomsaker TB | 2000 | Eur J Gastroenterol Hepatol2000，12，11： | 1 |
| 9 | Trends in diagnosisand surgical management of patients with perforated peptic ulcer显示文摘 | Thorsen K Glomsaker TB von Meer A | 2011 | JGastrointestSurg2011，15，8： | 1 |
| 10 | Asymptomatic common bile duct stones显示文摘 | Rosseland AR Glomsaker TB | 2000 | Eur J Gastroenterol Hepatol2000，12，11： | 1 |
| 11 | Asyapto matic common bile ductstomes显示文摘 | Rosseland AR Glomsaker TB | 2000 | Eur J Gastroenterol Hepatol2000，12，： | 1 |
| 12 | Trends in di- agnosis and surgical management of patients with perforated pep- tic ulcer 显示文摘 | Thorsen K Glomsaker T B von Meer A | 2011 | J Gastrointest Surg2011，15，8： | 1 |
| 13 | Pat- terns and predictive factors of complications after en- doscopic retrograde cholangiopancreatography显示文摘 | GLOMSAKER T HOFF G KVALOY J T | 2013 | Br J Surg2013，100，： | 1 |
| 14 | Asymptomatic common bile duct stones 显示文摘 | Rosseland AR Glomsaker TB | 2000 | Eur J Gastroenterol Hepatol2000，12，1： | 1 |
| 15 | Trends in diagnosis and surgical management of patients with perforated peptic ulcer 显示文摘 | Thorsen K Glomsaker TB von Meer A | 2011 | J Gastrointest Surg2011，15，8： | 1 |
| 16 | Trends in diagnosis and surgical management of patients with perforated peptic ulcer显示文摘 | Thorsen K Glomsaker TB yon Meer A | 2011 | J Gastrointest Surg2011，15，8： | 1 |
| 17 | Trends in diagnosis and sur- gical management of patients with perforated peptic ulcer显示文摘 | Thorsen K Glomsaker TB von Meer A | 2011 | J Gastrointest Surg2011，15，8： | 1 |
| 18 | Effects of Surface Irregularities on Flow Resistance in Differently Shaped Arterial Stenoses显示文摘 | Anderssonn H I Halden R Glomsaker T | 2000 | Journal of Biomechanics2000，33，10： | 1 |
| 19 | Effects of surface irregularities on flow resistance in differently shaped arterial stenoses显示文摘 | Anderssonn H I Halden R Glomsaker T | 2000 | Journal of Biomechanics2000，33，10： | 1 |
| 20 | Trends in diagnosis and surgical management of patients with perforated peptic ulcer 显示文摘 | Thorsen K Glomsaker TB von Meer A | 2011 | J Gastrointest Surg2011，15，8： | 1 |
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