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| 1 | Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition显示文摘 | GNOATTO S C B DASSONVILLE-KLIMPT A NASCIMENTO S D | 2008 | European Journal of Medicinal Chemistry2008，43，： | 1 |
| 2 | Synthesis and preliminary evaluation of new ursolic and oleanolic acids derivatives as antileishmanial agents显示文摘 | Gnoatto SC Dalla VL Lencina CL | 2008 | J Enzyme Inhib Med Chem2008，23，5： | 1 |
| 3 | Evaluation of Ursolic Acid Isolated from Ilex Paraguariensis andDerivatives on Aromatase Inhibition显示文摘 | Gnoatto S C B Klimpt A D Nascimento S D | 2008 | Eur J Med Chem2008，43，： | 1 |
| 4 | Triterpenoids from brazilian Ilex species and their in vitro antitypanosomal activity显示文摘 | Taketa ATC Gnoatto SCB Gosmann G | 2004 | J Nat Pord2004，，67： | 1 |
| 5 | Synthesis and prelimi- nary evaluation of new ursolic and oleanolic acids derivatives as an- tileishmanial agents 显示文摘 | Gnoatto SC Dalla VL Lencina CL | 2008 | J Enzyme Inhib Med Chem2008，23，5： | 1 |
| 6 | Triterpenoids from brazilian Ilex species and their in vitro antitrypanosomal activity 显示文摘 | TEKETA A T C GNOATTO S C B GOSMANN G | 2004 | J Nat Prod2004，67，： | 1 |
| 7 | Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice显示文摘 | Muller AP Gnoatto J Moreira JD | 2011 | Hippocampus2011，21，10： | 1 |
| 8 | HPLC method to assay total saponins in llex paraguariensis aqueous extract 显示文摘 | Gnoatto SCB Schenkel EP Bassani VL | 2005 | J Braz Chem Soc2005，16，： | 1 |
| 9 | Pharma- comodulation on the 3-acetylursolic acid skeleton:design, synthesis, and biological evaluation of novel N- { 3- propyl } -3-O-acetylursolamide derivatives as antimalarial agents 显示文摘 | Gnoatto S C Susplugas S Dalla Vechia L | 2008 | Bioorg Med Chem2008，16，2： | 1 |
| 10 | Synthesis and preliminary evaluation of new ursolic and oleanolic acids derivatives as antileishmanial agents显示文摘 | Gnoatto S C Dalla V L Lencina C L | 2008 | J Enzyme Inhib Med Chem2008，23，5： | 1 |
| 11 | Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice显示文摘 | Muller AP Gnoatto J Moreira JD | 2011 | Hippocampus2011，21，10： | 1 |
| 12 | Exercise increases insulin signaling in the hippocampus:physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice显示文摘 | Muller AP Gnoatto J Moreira JD Zimmer ER Haas CB Lulhier F | | 0，，： | 1 |
| 13 | Evaluation of ursolic acid isolated fromHex paraguarien- sis and derivatives on aromatase inhibition显示文摘 | Gnoatto S C B Dassonville Klimpt A Da Nascimento S | 2008 | Eur J Med Chem2008，43，9： | 1 |
| 14 | Effect of soy protein supplementation in patients with chronic hepatitis C:A randomized clinical trial显示文摘AIM:To evaluate the effects of soy supplementation on insulin resistance,fatty liver and alanine aminotransferase(ALT) levels in non-diabetic patients with chronic hepatitis C(CHC).METHODS:In a prospective,randomized and singleblinded clinical trial,we compared patients with CHC who had casein as a supplement(n = 80)(control group),with patients who consumed a soy supplement diet(n = 80) [intervention group(IG)].Both groups received 32 g/d of protein for 12 wk.RESULTS:Patients' baseline features showed that 48.1% were overweight,43.7% had abdominal fat accumulation,34.7% had hepatic steatosis and 36.3% had an homeostasis model assessment index of insulin resistance(HOMA-IR) ≥ 3.0.Descriptive analysis showed that protein supplementation diet reduced hepatic steatosis in both groups;however,significant reductions in ALT levels occurred in the soy group.Multiple regression modeling indicated that in the presence of severe fibrosis(F3/F4),g glutamyl transferase elevation and high density lipoprotein(HDL) reduction,the intervention group had 75% less chance of developing hepatic steatosis(OR= 0.25;95% CI:0.06-0.82) and 55% less chance of presenting with an ALT level ≥ 1.5 × the upper limit of normal(ULN)(OR = 0.45,95% CI:0.22-0.89).Soy treatment did not have any effect on insulin resistance(OR = 1.92;95% CI:0.80-4.83),which might be attributed to the fact that the HOMAIR values at baseline in most of our patients were in the normal range.Advanced hepatic fibrosis,an ALT level > 1.5 × ULN and visceral fat were predictors of an HOMA-IR ≥ 3.The IG group had a reduced risk of an ALT level > 1.5 × ULN.An HOMA-IR ≥ 3.0 and HDL < 35 mg/dL were also risk factors for increased ALT.CONCLUSION:Soy supplementation decreased ALT levels and thus may improve liver inflammation in hepatitis C virus(HCV) patients;it also reduced hepatic steatosis in a subgroup of patients but did not change insulin resistance.It should be considered in the nutritional care of HCV patients. | Lucivalda PM Oliveira Rosangela P de Jesus Ramona SSB Boulhosa Carlos Mauricio C Mendes Maria Cecilia Gnoatto Denise C Lemaire Maria Betania P Toralles Lourianne N Cavalcante Andre C Lyra Luiz GC Lyra | 2012 | World Journal of Gastroenterology2012，18，18： | 1 |
| 15 | Pedestrians Mobility on Public Sidewalks Evaluated by the IAAPE Method显示文摘 | Karla Conceicao Pereira Alcindo Neckel Henrique Aniceto Kujawa Mauricio Kunz Grace Cardoso Lauro André Ribeiro Caliane Christie Oliveira de Almeida Silva Pamela Gnoatto Paola Pol Saraiva Juliana Frighetto Tales Goncalves Visentin | 2017 | Journal of Civil Engineering and Architecture2017，11，8： | 0 |
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