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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Thirty-day mortality after ischemic stroke and intracranial hemorrhage in patients with atrial fibrillation on and off anticoagulants显示文摘 | Fang M C Go A S Chang Y | 2012 | Stroke2012，43，7： | 1 |
| 3 | Optimal Pricing and Ordering Policy under Permissible Delay in Payments 显示文摘 | TEN GJ T GHAN G C T GO YAL S K | 2005 | International Journal of Product on Economics2005，97，12： | 1 |
| 4 | Jeavons syndrome existing as occipital cortex initiating generalized epilepsy 显示文摘 | Viravan S Go C Ochi A | 2011 | Epilep-sia2011，52，7： | 1 |
| 5 | Scasonal patterns of nitriogen and denitrification in a natural and a restored salt marsh 显示文摘 | Paerl H W Go M C | 1995 | Estuaries1995，18，： | 1 |
| 6 | Clinical and molecular epidemiology of Acinetobacter infections sensitive only to polymyxin B and sulbactam 显示文摘 | Go E S Urban C Burns J | 1994 | Lancet1994，344，8933： | 1 |
| 7 | Seasonal patterns of nitrification and denitrification in a natural and a restored salt marsh显示文摘 | Thompson S P Paeri H W Go M C | 1995 | Estuaries1995，18，2： | 1 |
| 8 | Effects of supercritical carbon dioxide treatment for sterilization purpose on meat quality of porcine longissimus dorsi muscle 显示文摘 | Choi Y M Ryu Y C Lee S H Go H G Kim K H | 2008 | LWT-Food Science and Technology2008，41，2： | 1 |
| 9 | Valproic acid inhibits neural progenitor cell death by activation of NF-kappaB signaling path- way and up-regulatinn of BcI-XL 显示文摘 | Go H S Seo J E Kim K C | 2011 | J Biomed S ci2011，18，1： | 1 |
| 10 | Validity of compliance calibration to cracked concrete beams in bending显示文摘 | Swartz S E Go C G | 1984 | Experimental Mechanics1984，24，2： | 1 |
| 11 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 12 | Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease显示文摘 | Lo d C Chertow G M Go A S | 2005 | Kidney Int2005，67，： | 1 |
| 13 | Optimal Pricing and Ordering Policy under Permissible Delayin Payments显示文摘 | TEN G J CHANG C T GO YAL S K | 2005 | International Journal of Product on Economics2005，97，12： | 1 |
| 14 | Chronic kidney disease and the risks of death, cardi ovascular events,and hospitalization显示文摘 | Go A S Chertow G M Fan D McCulloch C E Hsu C Y | 2004 | N Engl J Med2004，351，： | 1 |
| 15 | Treatment of fa- :ial lipoatrophy with polymethylmethacrylate among patients with human immunodeficiency virus/acquired immunodefi- 'iency syndrome (HIV/AIDS): impact on the quality of Life 显示文摘 | Rodr/go C S Quintas Emmanuel R | 2014 | Int J Dermatol2014，53，4： | 1 |
| 16 | The Modeling and the Optimization of a Grating Optical Low-Pass Filter显示文摘 | Go C S Lim S Kim S | 2001 | Applied Physics B: Lasers and Optics2001，73，： | 1 |
| 17 | Use of satellite spectral data in crop yield estimation surveys显示文摘 | Singh R Go yal R C Saha S K | 1992 | Int J Remote Sens1992，13，13： | 1 |
| 18 | When does cowor- ker knowledge sharing matter to performance显示文摘 | Kim S L Han S Go C W | 2013 | Aca- demy of Management2013，，1： | 1 |
| 19 | Micropropagation of Pinus caribaea Morelrt显示文摘 | Halos S C Go N E | 1993 | Plant Cell Tiss Org Cult1993，32，： | 1 |
| 20 | Increased proliferation and gliogenesis of cultured rat neural progenitor cells by lipopolysaccharidestimulated astrocytes显示文摘 | Go H S Shin C Y Lee S H Jeon S J Kim K C Choi C S | | 0，，： | 1 |
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