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| 1 | Synthesis of N-phthalimido (-aminoethanesulfonyl chlorides:the use of thionyl chloride for a simple and efficient synthesis of new peptidosulfonamide building blocks 显示文摘 | Humljan J Gobec S | 2005 | Tetrahedron letters2005，46，： | 1 |
| 2 | Factors influencing dissipation of avermectins in sheep faeces显示文摘 | VIRANT CELESTINA T KOLAR L GOBEC I | 2010 | Ecotoxicology and Environmental Safety2010，73，1： | 1 |
| 3 | A one-pot conversion of a-aminoalkylphosphonous acids into rno-nomethyl a-aminoaikylphosphonates 显示文摘 | GOBEC S | 2004 | Synthesis-Stuttgart2004，，3： | 1 |
| 4 | Characteriza- tion of human lymphoblastoid cell lines as a novel in vitro test sys- tem to predict the immunotoxicity of xenobiotics 显示文摘 | MARKOVIC T GOBEC M GURWITZ D | 2015 | Toxicol Lett2015，233，1： | 1 |
| 5 | Factors influencing dissipation of avermectins in sheep faeces 显示文摘 | Virant C T Kolar L Gobec I | 2010 | Ecotoxicol Environ Saf2010，73，1： | 1 |
| 6 | Progestins as inhibitors of the human 20-ketosteroid reductases,AKR1C1 and AKR1C3显示文摘 | Berani?N Gobec S Ri?ner TL | 2011 | Chem Biol Interact2011，191，13： | 1 |
| 7 | Epoxide opening with a- mino acids: improved synthesis of hydroxyethylamine dipeptide isosteres 显示文摘 | Babi A Sova M Gobec S | 2006 | Tetrahedron Lett2006，47，11： | 1 |
| 8 | A novel scalable synthesis of pramipexole 显示文摘 | Zivec M Anzic B Gobec S | 2010 | Org Process Res Dev2010，14，5： | 1 |
| 9 | Inhibitors of cathepsin B 显示文摘 | Frlan R Gobec S | 2006 | Curr Med Chem2006，13，： | 1 |
| 10 | Melanin is crucial for growth of the black yeast Hortaea werneckii in its natural hy- persaline environment显示文摘 | Kejzar A Gobec S Plemenitas A | 2013 | Fungal Biology2013，117，5： | 1 |
| 11 | Cobalt-catalyzed crosscoupling of Grignards with Allylic and Vinylic Bromides:Use of Sarcosine as a Natural Ligand显示文摘 | Frlan R Sova M Gobec S | 2015 | J Org Chem2015，80，15： | 1 |
| 12 | Design,synthesis,biochemical evaluation and antimyco-bacterial action of phosphonate inhibitors of antigen 85C,a crucial enzyme involved in biosynthesis of the mycobacterial cell wall显示文摘 | Gobec S Plantan I Mravljak J | 2007 | Eur J Med Chem2007，42，1： | 1 |
| 13 | Factors infl uencing dissipation of avermectins in sheep faeces显示文摘 | Virant celestina T Kolar L Gobec T | 2010 | Ecotoxicology and Environmental Safety2010，73，1： | 1 |
| 14 | Effect of selective and non-selective β-blockers on body weight,insulin resistance and leptin concentration in chronic heart failure显示文摘 | Kovacié D Marinsek M Gobec L | | 0，，： | 1 |
| 15 | Factors influencing dissi- pation of avermeetins in sheep faeces 显示文摘 | Celestina T V Kolar L Gobec I | 2010 | Eeotoxieology and En- vironmental Safety2010，73，1： | 1 |
| 16 | Design,syn- thesis,biochemical evaluation and antimycobacterial action of phosphonate inhibitors of antigen 85C,a crucial enzyme involved in biosynthesis of the mycobacterial cell wall显示文摘 | GOBEC S PLANTAN I MRAVLJAK J | 2007 | Eur J Med Chem2007，42，： | 1 |
| 17 | 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases显示文摘We describe the development of quinolylnitrones(QNs)as multifunctional ligands inhibiting cholinesterases(ChEs:acetylcholinesterase and butyrylcholinesterase—h BChE)and monoamine oxidases(hMAO-A/B)for the therapy of neurodegenerative diseases.We identified QN 19,a simple,low molecular weight nitrone,that is readily synthesized from commercially available 8-hydroxyquinoline-2-carbaldehyde.Quinolylnitrone 19 has no typical pharmacophoric element to suggest ChE or MAO inhibition,yet unexpectedly showed potent inhibition of h BChE(IC50=1.06±0.31 nmol/L)and h MAO-B(IC_(50)=4.46±0.18μmol/L).The crystal structures of 19 with hBChE and hMAO-B provided the structural basis for potent binding,which was further studied by enzyme kinetics.Compound 19 acted as a free radical scavenger and biometal chelator,crossed the blood—brain barrier,was not cytotoxic,and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's disease.In addition,in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and coordination.Importantly,chronic treatment of double transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice,underscoring the disease-modifying effect of QN 19. | Damijan Knez Daniel Diez-Iriepa Mourad Chioua Andrea Gottinger Milica Denic Fabien Chantegreil Florian Nachon Xavier Brazzolotto Anna Skrzypczak-Wiercioch Ane Meden Anja Pilar Janko Kos Simon akelj Jure Stojan Kinga Saat Julia Serrano Ana Patricia Fernández Aitana Sánchez-García Ricardo Martínez-Murillo Claudia Binda Francisco López-Muoz Stanislav Gobec JoséMarco-Contelles | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 0 |
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