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| 1 | Involvement of microbial populations during the composting of olive mill wastewater sludge 显示文摘 | Abid N Chamkha M Godon J | 2007 | Environmental Technology2007，28，7： | 1 |
| 2 | TG1050,an immunotherapeutic to treat chronic hepatitis B,induces robust T cells and exerts an antiviral effect in HBVpersistent mice显示文摘 | Martin P Dubois C Jacquier E Dion S ManciniBourgine M Godon O Kratzer R Lelu-Santolaria K Evlachev A Meritet J F Schlesinger Y Villeval D Strub J M Van Dorsselaer A Marchand J B Geist M Brandely R Findeli A Boukhebza H Menguy T Silvestre N Michel M L InchauspéG | 2015 | Gut2015，64，12： | 1 |
| 3 | A climatology of airborne dust for the Red River Valley of North Dakota 显示文摘 | Godon N A Todhunter P E | 1998 | Atmospheric Environment1998，32，9： | 1 |
| 4 | A cross-calibration of chlorine isotopic measurements and suitability of seawater as the international reference material显示文摘 | Godon A Jendrzejewski N Eggenkamp H G M Banks D A Ader M Coleman M L Pineau F | 2004 | Chemical Geology2004，207，12： | 1 |
| 5 | : Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance显示文摘 | Beclin C Elmayan T Feuerbach F Godon C Morel JB Jouette D Lacombe AM Nikic S Picault N | 2000 | Cell2000，101，： | 1 |
| 6 | The molecular evolution of Mycobacterium boris显示文摘 | Smith N H Godon R R Clifton-Hadley S | 2006 | Nat Rev Microbiol2006，4，： | 1 |
| 7 | Experimental Investigation of Aqueous Corrosion of R7T7 Nuclear Glass at 90℃ in the Presence of Humic Acids:A Kinetic Approach显示文摘 | Gin S Godon N Mestre J P | 1994 | Appl Geochem1994，9，： | 1 |
| 8 | Role of shear stress on composition , diversity and dynamics of biofilm bacterial communities显示文摘 | Rochex A Godon J J Bemet N | 2008 | Water Research2008，42，： | 1 |
| 9 | A cross-calibration of chlorine isotopic measurements and suitability of seawater as the international reference material 显示文摘 | GODON A JENDRZEJEWSKI N EGGENKAMP H G M BANKS D A ADER M COLEMAN M L PINEAU F | 2004 | Chemical Geology2004，207，12： | 1 |
| 10 | Role of shear stress on composition, diversity and dynamics of biofilm bacterial communities 显示文摘 | ROCHEX A GODON J BERNET N | 2008 | Water Research2008，42，20： | 1 |
| 11 | Behaviour of pathogenic and indicator bacteria during urban wastewater treatment and sludge composting,as revealed by quantitative PCR显示文摘 | Wéry N Lhoutellier C Ducrayc F Delgenèsa J.P Godon J.J | | 0，，1： | 1 |
| 12 | Experimental investigation of aqueous corrosion of R7T7 nuclear glass at 90 ℃ in the presence of organic species显示文摘 | Gin S Godon N Mestre JP | 1994 | Appl Geochem1994，9，3： | 1 |
| 13 | Retinoid signaling in immortalized and carcinoma-derived human uroepithelial cells显示文摘 | Waliszewski P Waliszewska M Godon N | 1999 | Mol Cell Endocrinol1999，148，12： | 1 |
| 14 | Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance显示文摘 | Béclin C Elmayan T Feuerbach F Godon C Mortl J-B Jouette D Lacombe A-M Nikic S Picault N Rémoué K Sanial M Vo T-A Vaucheret H | 2000 | Cell2000，101，： | 1 |
| 15 | Added value of molecular karyotype in childhood acute lymphoblastic leukemia显示文摘Background:Thanks to an improved therapeutic regimen in childhood B-cell precursor acute lymphoblastic leukemia(BCP-ALL),5 year-overall survival now exceeds 90%.Unfortunately,the 25%of children who relapse have an initial poor prognosis,potentially driven by pre-existing or emerging molecular anomalies.The latter are initially and essentially identified by cytogenetics.However,some subtle alterations are not visible through karyotyping.Methods:Single nucleotide polymorphisms(SNP)array is an alternative way of chromosomal analysis allowing for a more in-depth evaluation of chromosomal modifications such as the assessment of copy number alterations(CNA)and loss of heterozygosity(LOH).This method was applied here in retrospective diagnosis/relapse paired samples from seven children with BCP-ALL and in a prospective cohort of 38 newly diagnosed childhood cases.Results:In the matched study,compared to the initial karyotype,SNP array analysis reclassified two patients as poor prognosis cases.Modulation during relapse was seen for 4 CNA and 0.9 LOH.In the prospective study,SNP reclassified the 10 patients with intermediate karyotype as 7 good prognosis and 3 poor prognosis.Ultimately,in all the children tested,SNP array allowed to identify additional anomalies compared to conventional karyotype,refine its prognostic value and identify some druggable anomalies that could be used for precision medicine.Overall,the anomalies detected could be segregated in four groups respectively involved in B-cell development,cell proliferation,transcription and molecular pathways.Conclusion:SNP therefore appears to be a method of choice in the integrated diagnosis of BCP ALL,especially for patients initially classified as intermediate prognosis.This complementary method of both cytogenetics and high throughput sequencing allows to obtain further classified information and can be useful in case of failure of these techniques. | Margaux Camuset Baptiste Le Calvez Olivier Theisen Catherine Godon Audrey Grain Caroline Thomas Marie-Laure Couec Marie C.Béné Fanny Rialland Marion Eveillard | 2023 | Cancer Innovation2023，2，6： | 0 |
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