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| 1 | Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain显示文摘Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology. | Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau Pierre-Fran?ois Laterre Pierre Goffette Chantal De Reyck Beno?t Lengelé Pierre Gianello Jan Lerut | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 5 |
| 2 | The arterioportal fistula syndrome: Clinicopathologic features, diagnosis, and therapy显示文摘 | JN Vauthey RJ Tomczak T Helmberger P Gertsch C Forsmark J Caridi A Reed MR Langham GY Lauwers P Goffette J Lerut | 1997 | Gastroenterology1997，，4： | 2 |
| 3 | Sequential treatment of HRS and posthepatie cirhhosis by TIPS and liver transplantation显示文摘 | Lerut J Goffette P | 1995 | Hepatogastroenterology1995，42，： | 1 |
| 4 | Surgical clipping may lead to better results than coli embolization:results from a series of 101 consecutive nonruptured intracranial aneurysms显示文摘 | RAFTOPOULOS C GOFFETTE P VAZ G | 2003 | Neurosurgery2003，52，： | 1 |
| 5 | The intrathecal humoral immune response: laboratory analysis and clinical elevance 显示文摘 | Sindic CJ Van ± antwerpen MP Goffette S | 2001 | Clin chem LabMed2001，39，4： | 1 |
| 6 | The intrathecal humoral immune response: laboratory analysis and clinical relevance 显示文摘 | Sindic C J Van Antwerpen MP Goffette S | 2001 | Clin Chem Lab Med2001，39，4： | 1 |
| 7 | Traumatic injuries:imaging and interven- tion in post-traumatic complications(delayed intervention)显示文摘 | Goffette PP Laterre PF | 2002 | Eur Radiol2002，12，5： | 1 |
| 8 | Demonstration of pulmonary embolism with gadolinium-enhanced spiral CT 显示文摘 | CHCHE EE HAMMER FA GOFFETTE PP | 2001 | Eur Radiol2001，11，11： | 1 |
| 9 | Acute intestinal ischemia due to occlusion of superior mesenteric artery:detection with Doppler sonography显示文摘 | Danse EM Vanbeers BE Goffette P | 1996 | Ultrasound Med1996，15，4： | 1 |
| 10 | Surgical clipping may lead to tetter results than coil embolization: results from a series of 101 consecutive unruptured intracranial aneurysms 显示文摘 | Raftopoulos C Goffette P Vaz G | 2003 | Neurosurgery2003，52，6： | 1 |
| 11 | Traumatic injuries: imaging and intervention in post-traumatic complications (delayed intervention) 显示文摘 | Goffette PP Laterre PF | 2002 | Eur Radiol2002，12，5： | 1 |
| 12 | Long-term survival after isolated liver transplantation for intrahepatic biliary papillomatosis 显示文摘 | Charre L Boillot O Goffette P | 2006 | Transpl Int2006，19，： | 1 |
| 13 | Transvascular coil hooking procedure to retrieve an unraveled Guglielmi detachable coil: technical note显示文摘 | Raftopoulos C Goffette P Billa RF | 2002 | Neurosurgery2002，50，4： | 1 |
| 14 | Surgical clipping may lead to better results than coil embolization: results from a series of 101 consecutive unruptured intracranial aneurysms 显示文摘 | Raftopoulos C Goffette P Vaz G | 2003 | Neumsurgery2003，52，6： | 1 |
| 15 | Meso-Rex bypass for the management of extrahepatic portal vein obstruction in adults(with video)显示文摘Background:Extrahepatic portal vein obstruction(EHPVO)results in severe portal hypertension(PHT)leading to severely compromised quality of life.Often,pharmacological and endoscopic management is unable to solve this problem.Restoring hepatic portal flow using meso-Rex bypass(MRB)may solve it.This procedure,uncommon in adult patients,is considered the treatment of choice for EHPVO in children.Methods:From 1997 to 2018,8 male and 6 female adults,with a median age of 51 years(range 22-66)underwent MRB procedure for EHPVO at the University Hospitals Saint-Luc in Brussels,Belgium.Symp-toms of PHT were life altering in all but one patient and consisted of repetitive gastro-intestinal bleedings,sepsis due to portal biliopathy,and/or severe abdominal discomfort.The surgical technique consisted in interposition of a free venous graft or of a prosthetic graft between the superior mesenteric vein and the Rex recess of the left portal vein.Results:Median operative time was 500 min(range 300-730).Median follow-up duration was 22 months(range 2-169).One patient died due to hemorrhagic shock following percutaneous transluminal interven-tion for early graft thrombosis.Major morbidity,defined as Clavien-Dindo score≥III,was 35.7%(5/14).Shunt patency at last follow-up was 64.3%(9/14):85.7%(6/7)of pure venous grafts and only 42.9%(3/7)of prosthetic graft.Symptom relief was achieved in 85.7%(12/14)who became asymptomatic after MRB.Conclusions:Adult EHPVO represents a difficult clinical condition that leads to severely compromised quality of life and possible life-threatening complications.In such patients,MRB represents the only and last resort to restore physiological portal vein flow.Although successful in a majority of patients,this procedure is associated with major morbidity and mortality and should be done in tertiary centers expe-rienced with vascular liver surgery to get the best results. | Martin Brichard Samuele Iesari Jan Lerut Raymond Reding Pierre Goffette Laurent Coubeau | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，1： | 1 |
| 16 | Traumatic injuries; imaging and intervention in post-traumatic complications(delayed intervention)显示文摘 | Goffette PP Laterre PF | 2002 | Eur Radiol2002，12，5： | 1 |
| 17 | Percutaneous and surgical radiofrequency ablation of liver malignancies:a single institutional experience显示文摘 | HUBERT C GRAS J GOFFETTE P | 2007 | Acta Gastroenterol Belg2007，70，2： | 1 |
| 18 | The intrathecal humoral immune response:laboratory analysis and clinical relevance显示文摘 | Sindic CJ Van Antwerpen MP Goffette S | 2001 | Clin Chem Lab Med2001，39，4： | 1 |
| 19 | The Intrathecal Humoral Immune Response: Laboratory Analysis and Clinical Relevance显示文摘 | Christian J.M. Sindic Marie-Paule Van Antwerpen Sophie Goffette | 2001 | Clinical Chemistry and Laboratory Medicine2001，，： | 1 |
| 20 | Transjugular intrahepatic portosystcmic shunt approach and local thrombolysis for treatment of early posttransplant portal vein thrombosis 显示文摘 | Ciccarelli O Goffette P Laterre P F | 2001 | Transplantation2001，72，1： | 1 |
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