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| 1 | Thyroid hormone analogues and derivatives:Actions in fatty liver显示文摘Fatty liver or nonalcoholic fatty liver disease(NAFLD),a problem of increasing clinical significance and prevalence worldwide,is associated with increased risk for the development of cirrhosis and hepatocellular carcinoma.Although several therapeutic approaches can be used in the context of NAFLD,dietary and physical activities are still the most frequently used strategies.Some pharmacological agents show promising results although no conclusions can be drawn from recent clinical trials.Thyroid hormones[THs;thyroxine(T4)and3,3′,5-triiodo-L-thyronine(T3)]coordinate a diverse array of physiological events during development and lipid/energy homeostasis and have some potentially therapeutic actions which include inducing weight loss,and lowering plasma cholesterol levels and tissue adiposity.The thyroid hormones exert their physiological effects by binding to specific nuclear receptors[thyroid hormone receptors(TR)]of which the TRβisoform is liver specific and has been considered a putative target for the treatment of dyslipidemia and fatty liver.In view of this,the aim of the review is(1)to provide an overview of the action of T3 on lipid metabolism with implications for liver steatosis and(2)to provide an update on the current knowledge concerning the administration of TRβselective thyromimetics(GC-1 and MB07811),as well as of 3,5-diiodo-L-thyronine and its novel functional analogue TRC150094 in animal models of overweight and related disorders including primarily fatty liver. | Maria Coppola Daniela Glinni Maria Moreno Federica Cioffi Elena Silvestri Fernando Goglia | 2014 | World Journal of Hepatology2014，6，3： | 3 |
| 2 | Direct effects of iodothyronines on excess fat storage in rat hepatocytes显示文摘 | Elena Grasselli Adriana Voci Laura Canesi Rita De Matteis Fernando Goglia Federica Cioffi Emilia Fugassa Gabriella Gallo Laura Vergani | 2010 | Journal of Hepatology2010，，6： | 2 |
| 3 | 3,5-diiodo- l -thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet显示文摘 | Maria Pina Mollica Lillà Lionetti Maria Moreno Assunta Lombardi Pieter De Lange Alessandro Antonelli Antonia Lanni Gina Cavaliere Antonio Barletta Fernando Goglia | 2009 | Journal of Hepatology2009，，2： | 2 |
| 4 | Biological effects of 3,5-diiodothyronine (T 2 )显示文摘 | F. Goglia | 2005 | Biochemistry (Moscow)2005，，2： | 2 |
| 5 | The effect of surface irregularities on the elastohydrodynamic lubrication of sliding line contacts, Part Ⅱ-wavy surface显示文摘 | GOGLIA P CUSANO C CONRY T F | 1984 | ASME Journal of Tribology1984，106，： | 1 |
| 6 | Action of thyroid hormones at the cellular level: the mitochondrial target显示文摘 | Fernando Goglia Maria Moreno Antonia Lanni | 1999 | FEBS Letters1999，，3： | 1 |
| 7 | In vitro binding of triiodothyronine to rat liver mitochondria显示文摘 | F. Goglia J. Torresani P. Bugli A. Barletta G. Liverini | 1981 | Pflügers Archiv European Journal of Physiology1981，，2： | 1 |
| 8 | Short term bone level observations associated with platform switching in immediately placed and restored single maxillary replants: a preliminary report显示文摘 | Canullo L Goglia G Iurlaro G | 2009 | Int J Prosthodont2009，22，3： | 1 |
| 9 | Endothelial regulation of eNOS, PAI- 1 and t- PA by testosterone and dihydrotestosterone in vitro and in vivo显示文摘 | Goglia L Tosi V Sanchez AM | 2010 | MolHum Reprod2010，16，10： | 1 |
| 10 | VPAfunction for novel uncoupling proteins : anfioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet显示文摘 | Goglia F Skulachev | 2003 | FASEB J2003，17，12： | 1 |
| 11 | The effects of surface irregu- larities on the elastohydrodynamic lubrication of sliding line contacts : Part I : Single Irregularities 显示文摘 | Goglia P R Conry T F Cusano C | 1984 | Journal of Tribology1984，106，1： | 1 |
| 12 | Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion 显示文摘 | Fu XD Giretti MS Goglia L | 2008 | BMC Cancer2008，8，2： | 1 |
| 13 | Atomization of liquids in high velocity gas streams显示文摘 | Lewis H C Edwards D G Goglia M J Rich R I Smith L W | 1948 | Ind Engr Chem1948，40，1： | 1 |
| 14 | VPA function for novel uncoupling proteins:antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet显示文摘 | Goglia F Skulachev | 2003 | FASEB J2003，17，12： | 1 |
| 15 | A function for novel uncouplingproteins:antioxidant defense of mitochondrial matrixbytranslocating fatty acid peroxides from the inner to theouter membrane leaflet显示文摘 | Goglia F Skulachev VP | 2003 | Faseb J2003，17，12： | 1 |
| 16 | Air Permeability of Parachute Cloths显示文摘 | GOGLIA M J LAVIER H W S BROWN C D | 1955 | Textile Research Journal1955，25，1： | 1 |
| 17 | Action of thyroid hormones at the cellular level:the mitochondrial target显示文摘 | Goglia F Moreno M Lanni A | | 0，，03： | 1 |
| 18 | Burt AM Generational Boundary Dis tortions By Adult Children Aleoholies显示文摘 | Goglia LR Jurkovie GJ | 1992 | American Journal Of Family Therapy1992，20，4： | 1 |
| 19 | 3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by adenosine-5'-triphosphate显示文摘 | Arnold S Goglia F Kadenbach B | | 0，，02： | 1 |
| 20 | Short term bone level observations associated with platform swilching in immediately placed and restored single maxillary implants : a preliminary report 显示文摘 | Canullo L Goglia G Iurlaro G el al | 2009 | Int J Prosthodont2009，22，3： | 1 |
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