|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | A stochastic model for risk management in global supply chain networks显示文摘 | Mark Goh Joseph Y.S. Lim Fanwen Meng | 2006 | European Journal of Operational Research2006，，1： | 2 |
| 3 | Immunoglobulin G in non-alcoholic steatohepatitis predicts clinical outcome:A prospective multi-centre cohort study显示文摘BACKGROUND Autoimmune markers including plasma cells(PC),anti-smooth-muscle antibody(ASMA),anti-nuclear antibody(ANA),and raised immunoglobulin G(IgG)are commonly observed in non-alcoholic steatohepatitis(NASH),however their clinical significance is unknown.AIM To determine if autoimmune markers in NASH patients are independently associated with poorer clinical outcomes.METHODS Consecutive patients with biopsy proven NASH from Christchurch Hospital,New Zealand and Singapore General Hospital(SGH)were included between 2005 to 2016 in a prospective multi-centre cohort study.Patients with other causes of chronic liver disease were excluded.IgG>14 g/L or globulin fraction>50%,ANA≥1:40,SMA≥1:40 were considered positive.Multivariate analysis was performed to assess which markers were independently associated with mortality and hepatic decompensation.RESULTS Total 261 patients were included of which 201 were from SGH.The median age was 53 and 51.9%were male.Advanced fibrosis was present in 31.4%at diagnosis.PC,ASMA,ANA and raised IgG were observed in 13.1%,4.9%,27.8%and 30.1%of patients respectively.After multivariate analysis,elevated IgG[Hazard Ratio(HR)6.79,95%CI:2.93-17.15]and fibrosis stage(HR 1.37,95%CI:1.03-1.87)were found to be independently associated with increased risk of liver decompensation.Age(HR 1.06,95%CI:1.02-1.10)and elevated IgG(HR 3.79,95%CI:1.90-7.68)were independent factors associated with higher mortality risk.CONCLUSION Elevated IgG,rather than ANA,ASMA or plasma cells,is independently associated with increased risk of hepatic decompensation and mortality in NASH.It could hence be important for prognostication. | Marianne Anastasia De Roza Mehul Lamba George Boon-Bee Goh Johnathan Huey-Ming Lum Mark Chang-Chuen Cheah Jing Hieng Jeffrey Ngu | 2021 | World Journal of Gastroenterology2021，27，43： | 2 |
| 4 | Modeling carbon footprints across the supply chain显示文摘 | Balan Sundarakani Robert de Souza Mark Goh Stephan M. Wagner Sushmera Manikandan | 2010 | International Journal of Production Economics2010，，： | 2 |
| 5 | 计算最小体积覆盖椭球的坐标轴下降算法显示文摘最小体积覆盖椭球问题是一个基本的凸优化问题.本文给出最小体积覆盖椭球问题的新性质—对算法依坐标轴光滑性,据此提出一种坐标轴下降算法来计算最小体积覆盖椭球并证明该算法的收敛速度是全局次线性收敛且局部线性收敛的.从计算时间角度来看,该算法优于经典的Frank-Wolfe算法,并且这种优势对于高维数据集尤为明显.更进一步,我们发现该算法在计算最小体积覆盖椭球问题方面比随机坐标轴下降算法更有优势.最后通过大规模数值算例测试来验证我们得到的理论结果. | 陶杰 张威 卢超 Mark Goh | 2021 | 中国科学:数学2021，51，12： | 2 |
| 6 | Wagner and Sushmem Manikandan Modeling Carbon Footprints Across the Supply Chain显示文摘 | Balan Sundaraknni Robert de Souza Mark Goh Stephan M | | 0，，01： | 1 |
| 7 | A continuous time model for multiple yard crane scheduling with last minute job arrivals显示文摘 | LI Wenkai GOH Mark WU Yong | 2012 | International Journal of Production Economics2012，136，2： | 1 |
| 8 | Quality of life 17 to 20 years after uvulopalatopharyngoplasty显示文摘 | Goh Y H Mark I Fee W E | 2007 | Laryngoscope2007，117，： | 1 |
| 9 | Setting operating policies for supply hubs 显示文摘 | Janat Shah Mark Goh | 2006 | International Journal of Production Economies2006，100，2： | 1 |
| 10 | The effects of remifentanil and thoracic epidural on oxygenation and pulmonary shunt fraction during one-lung ventilation显示文摘 | Mark Yew-Hoong Chow Meng-Huat Goh Sek Koon Boey Agasthian Thirugnanam Pierre Christian Ip-Yam | 2003 | Journal of Cardiothoracic and Vascular Anesthesia2003，，1： | 1 |
| 11 | Some Logistics Realities in Indochina显示文摘 | Mark Goh Argus Ang | 2000 | International Journal of Physical Distribution-Logistics Man- agement2000，3，10： | 1 |
| 12 | Logidtics Development in China显示文摘 | Mark Goh Charlene Ling | 2003 | International Journal of Physical Distribution & Logistics Management2003，，33： | 1 |
| 13 | An effective mathematical formulation for the unidirectional cluster-based quay crane scheduling problem显示文摘 | Jiang Hang Chen Der-Horng Lee Mark Goh | 2013 | European Journal of Operational Research2013，，： | 1 |
| 14 | Discrete time model and algorithms for container yard crane scheduling 显示文摘 | Li Wenkai Goh Mark Wu Yong | 2010 | European Journal of Operational Research2010，198，： | 1 |
| 15 | A continuous time model for multiple yard crane scheduling with last minute job arrivals 显示文摘 | Li Wenkai Goh Mark Wu Yong | 2012 | International Journal of Produc- tion Economics2012，136，： | 1 |
| 16 | Three-dimensional bin packing problem with variable bin height显示文摘 | Wu Yong Li Wwekai Goh Mark | 2010 | European Journal of Operational Research2010，202，2： | 1 |
| 17 | Container port efficiency in emerging andmore advanced markets显示文摘 | Yen-Chun Jim Wu Mark Goh | 2010 | Transportation Research Part E2010，46，： | 1 |
| 18 | Density, Distance and Division: the Case of Chongqing Municipality, China 显示文摘 | Mark Roberts Chor- ching Goh | 2011 | Cambridge Journal of Regions Economy and Society2011，，6： | 1 |
| 19 | Buyer-seller Relationships in the PCB Industry显示文摘 | Geok Theng Lau and Mark Goh | | Supply Chain0，，： | 1 |
| 20 | Quality of life 17 to 20 years after uvulopalatopharyngoplasty 显示文摘 | Goh YH Mark I Fee we Jr | 2007 | Larynqoscope2007，117，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员