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| 1 | Blood flow restriction in human skeletal muscle during rest periods after high-load resistance training down-regulates miR-206 and induces Pax7显示文摘Backgroud:Blood flow re striction(BFR) with low-intensity re sistance training has been shown to result in hypertrophy of skeletal muscle.In this study,we tested the hypothesis that BFR during the rest periods between acute,high-intensity resistance exercise sessions(70% of 1 repetition maximum,7 sets with 10 repetitions) enhances the effects of the resistance training.Methods:A total of 7 healthy young men performed squats,and between sets BFR was carried out on one leg while the other leg served as a control.Because BFR was applied during rest periods,even severe occlusion pressure(approximately 230 mmHg),which almost completely blocked blood flow,was well-tolerated by the participants.Five muscle-specific microRNAs were measured from the biopsy samples,which were taken 2 h after the acute training.Results:Doppler data showed that the pattern of blood flow recovery changed significantly between the first and last BFR.microRNA-206 levels significantly decreased in the BFR leg compared to the control.The mRNA levels of RAC-β serine/threonine-protein kinase v22,nuclear re spiratory factor 1,vascular endothelial growth factor,lupus Ku autoantigen protein p70 genes(p <0.05),and paired box 7(p <0.01) increased in the BFR leg.The protein levels of paired box 7,nuclear respiratory factor 1,and peroxisome proliferator-activated receptor y coactivator 1α did not differ between the BFR leg and the control leg.Conclusion:BFR,during the rest periods of high-load resistance training,could lead to mRNA elevation of those proteins that regulate angiogenesis,mitochondrial biogenesis,and muscle hypertrophy and repair.However,BFR also can cause DNA damage,judging from the increase in mRNA levels of lupus Ku autoantigen protein p70. | Ferenc Torma Zoltan Gombos Marcell Fridvalszki Gergely Langmar Zsofia Tarcza Bela Merkely Hisashi Naito Noriko Ichinoseki-Sekine Masaki Takeda Zsolt Murlasits Peter Osvath Zsolt Radak | 2021 | Journal of Sport and Health Science2021，10，4： | 3 |
| 2 | The roles of microRNA in redox metabolism and exercise-mediated adaptation显示文摘MicroRNAs(miRs)are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex.miRs are involved in the regulation of cellular processes producing,eliminating or repairing the damage caused by reactive oxygen species,and they are active players in redox homeostasis.Increased mitochondrial biogenesis,function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise.In the present review,we highlight some of the redox-sensitive regulatory roles of miRs. | Ferenc Torma Zoltan Gombos Matyas Jokai Istvan Berkes Masaki Takeda Tatsuya Mimura Zsolt Radak Ferenc Gyori | 2020 | Journal of Sport and Health Science2020，9，5： | 2 |
| 3 | Peritumoral lymphatic vessel density and wtscular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix 显示文摘 | Gombos Z Xu X Chu CS | 2005 | Clin Cancer Res2005，11，23： | 1 |
| 4 | Intraosseous glomus tumor of the great toe : a case report with review of the literature显示文摘 | Gombos Z Fogt F Zhang PJ | 2008 | J Foot Ankle Surg2008，47，4： | 1 |
| 5 | The lipid com- position of adult rat brain synaptosomal plasma membranes显示文摘 | BKECKENRIDGE W GOMBOS G MORGAN I | 1972 | Biochi- mica et Biophysica Acta (BBA) -Biomembranes1972，266，3： | 1 |
| 6 | miRNA expression profiles of oral squamous cell carcinomas显示文摘 | Gombos K Horvath R Szele E | | 0，，4： | 1 |
| 7 | Red cell distribution width in heart failure:prediction of clinical events and relationship with markers of ineffective erythropoiesis,inflammation,renal function,and nutritional state显示文摘 | Forhecz Z Gombos T Borgulya G | | 0，，4： | 1 |
| 8 | Targeted mutagenesis of acyl-lipid desaturase in synichocystis:evidence for the important roles of polyunsaturated membrane lipids in growth respiration and photosynthesis显示文摘 | Tasaka Y Gombos Z Nishiyaa Y | 1996 | EMBO J1996，15，23： | 1 |
| 9 | Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutri- tional state显示文摘 | Forhecz Z Gombos T Borgulya G | 2009 | Am Heart J2009，158，4： | 1 |
| 10 | MieroRNA expressions in HPV-induced cervical dysplasia and cancer 显示文摘 | Gocze K Gombos K Kovacs K | 2015 | Antieaneer Res2015，35，1： | 1 |
| 11 | Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix显示文摘 | XU X CHU C S | 2005 | Clin Cancer Res2005，11，23： | 1 |
| 12 | Red cell distribution width in heart failure:prediction of clinical events and relationship with markers of ineffective erythropoiesis,inflammation,renal function,and nutritional state显示文摘 | F(o)rhécz Z Gombos T Borgulya G | 2009 | Am Heart J2009，158，： | 1 |
| 13 | Red cell distribution width in heart failure : Prediction of clinical events and relationship with markers of in effective erythropoiesis, inflammation renal function and nutritional state显示文摘 | Fsrhecz Z Gombos T Borgulya G | 2009 | Am Heart J2009，158，4： | 1 |
| 14 | Red cell distribution width in heart failure: prediction of clinical events and relationship with markers of ineffective erythropoiesis, inflammation, renal function, and nutritional state显示文摘 | Forhecz Z Gombos T Borgnlya G | 2009 | Am Heart J2009，158，4： | 1 |
| 15 | Red cell distribution width in heart failure:prediction of clinical events and relationship with markers of ineffective eiythropoiesis,inflammation,renal function,and nutritional state显示文摘 | Forhecz Z Gombos T Borgulya G | | 0，，4： | 1 |
| 16 | Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix显示文摘 | Gombos Z Xu X Chu CS | 2005 | Clin Cancer Res2005，11，23： | 1 |
| 17 | Interaction of serum70-k Da heat shock protein levels and Hsp A1B(+1267)gene polymorphism with disease severity in patients with chronic heart failure显示文摘 | Gombos T Frhécz Z Pozsonyi Z | 2008 | Cell Stress Chaperones2008，13，2： | 1 |
| 18 | Red cell distribution width in heart failure:prediction of clinical events and relationship with markeers of ineffective erythropoiesis,inflammation,renal function,and nutritional state显示文摘 | Forhecz Z Gombos T Borgulya G | | 0，，： | 1 |
| 19 | Increased stiffness of the rat liver precedes matrix deposition:implications for fibrosis显示文摘 | Georges PC Hui JJ Gombos Z | 2007 | Am J Physiol Gastrointest Liver Physiol2007，293，6： | 1 |
| 20 | Color Doppler imaging of fibroadenomas of the breast with histopathologie correlation显示文摘 | Strano S Gombos EC Friedland O | 2004 | J Clin Ultrasound2004，32，2： | 1 |
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