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| 1 | 糖尿病膀胱病的临床尿动力学研究显示文摘目的观察糖尿病膀胱病(DCP)患者的尿动力学改变,探讨发病机制及病理演绎过程,减少晚期DCP的发生,为早期诊治提供依据。方法按糖尿病患者病程分为:早期DCP患者组(32例),晚期DCP组(28例)及非糖尿病人群对照组(22例)分别进行尿动力学测定,获得最大尿流率、排尿量、初始感膀胱容量、最大膀胱压力、最大逼尿肌压、最大膀胱容量、残余尿、膀胱颈压、最大尿道压及括约肌肌电图等参数,对以上数据作相关统计学处理。结果相对于正常对照组,早期DCP患者最大尿流率偏低[(15.97±5.71)ml/s,P<0.05],逼尿肌活动亢进(占59%),逼尿肌/括约肌协同失调(占37.5%);而晚期DCP患者最大尿流率明显下降[(8.75±4.20)ml/s,P<0.01],膀胱容量增加[(472.5±32.9)ml,P<0.01],残余尿量增多[(62.59±19.87)ml,P<0.01],逼尿肌收缩功能减弱。结论糖尿病患者在早期就有膀胱尿道的动力学改变,以逼尿肌活动功能亢进、逼尿肌/括约肌协同失调较常见,晚期以逼尿肌收缩功能减弱为主,建议对DCP患者早期就应给予干预,控制病情的进一步恶化。 | 卫中庆 田成功 Gommert van Koeveringe 王昱 孙则禹 于洪波 易超然 陈炜 Philip van Kerrebreck | 2005 | 医师进修杂志(外科版)2005，28，10： | 9 |
| 2 | M 3 Muscarinic Receptor-Like Immunoreactivity in Sham Operated and Obstructed Guinea Pig Bladders显示文摘 | Simone Grol Christopher John Nile Piluca Martinez-Martinez Gommert van Koeveringe Stefan de Wachter Jan de Vente James I. Gillespie | 2011 | The Journal of Urology2011，，5： | 1 |
| 3 | Re-gional differences in sensory innervation and suburothelial inter-stitial cells in the bladder neck and urethra显示文摘 | SIMONE GROL GOMMERT A VAN KOEVRINGE | 2008 | Bju International2008，10，2： | 1 |
| 4 | 早期糖尿病大鼠膀胱的动力学及病理组织学显示文摘目的观察早期糖尿病性膀胱病(DCP)的尿动力学及病理学改变,探讨其发病机制及病理演绎过程。方法建立早期糖尿病大鼠模型(30只),以正常大鼠(30只)作对照,饲养60 d后,进行膀胱静态压、最大膀胱容量、最大膀胱收缩压等尿动力学指标测定。然后行膀胱湿重、膀胱壁厚度及光镜、电镜病理学观察。结果60 d后,糖尿病组膀胱静态压、最大膀胱容量、最大膀胱收缩压、膀胱顺应性、膀胱湿重、膀胱壁厚度分别为(0.95±0.10)kPa、(3.49±0.40)ml、(3.09±0.10)kPa、(1.39±0.11)ml/kPa、(182.0±1.5)mg、(1.41±0.07)mm,而对照组分别为(0.60±0.03)kPa、(1.82±0.12)ml、(4.91±0.30)kPa(0.68±0.07)ml/kPa、(149.0±1.4)mg、(0.93±0.04)mm。两组对应参数相比,差异均有统计学意义(P<0.05或<0.01)。糖尿病组膀胱逼尿肌边缘有空泡样变性、肌细胞固缩、细胞连接纤维化、成纤维细胞变性及胶原纤维排列紊乱。结论DCP大鼠早期就有膀胱的动力学及病理学改变,提示对DCP患者应尽早干预,控制病情的进一步恶化。 | 卫中庆 Gommert van Koeveringe 严春寅 田成功 易超然 孙则禹 侯建全 温端改 Philip Van Kerrebroeck | 2008 | 苏州大学学报(医学版)2008，28，3： | 1 |
| 5 | Alternative mechanisms for prostate-specific antigen elevation:A prospective analysis of 222 transurethral resections of prostate patients显示文摘AIM: To investigate the relationship between prostatespecific antigen(PSA) levels and(1) bladder outlet obstruction(BOO) and(2) the severity of prostate inflammation.METHODS: Two hundred and twenty-two consecutive patients undergoing transurethral resection of the prostate(TURP) were prospectively included. Patients with proven urinary tract infection and/or known prostate cancer were excluded. PSA levels, International Prostate Symptoms Score(IPSS), prostate weight, post residual volume and pressure flow parameters were determined. A histopathological assessment of the presence and severity of inflammation was also performed.RESULTS: Patients had a mean age of 69.1 ± 8.6 years(45-90 years), with mean preoperative PSA levels of 4.7 ± 5.4 ng/m L(0.2-32.5 ng/m L) and IPSS of 15.7 ± 6.9(0-32). Mean Pdet Q max was 96.3 ± 34.4 cm H2O(10-220 cm H2O). The mean resected prostate weight was 39.4 ± 27.3 g(3-189 g). Correlations were observed between PSA(logarithmic) and resected prostate weight(r = 0.54; P < 0.001), PSA(logarithmic) and Pdet Q max(r = 0.17; P = 0.032), and resected prostate weight and Pdet Q max(r = 0.39; P < 0.001). Furthermore, low correlations were observed between PSA(logarithmic) and active(r = 0.21; P < 0.0001) and chronic(r = 0.19; P = 0.005) inflammation. CONCLUSION: In this study we showed a correlation between BOO(Pdet Q max) and PSA(logarithmic). Furthermore, we demonstrated a weak correlation between PSA(logarithmic) and active as well as chronic prostatic inflammation. | Koenraad van Renterghem JJMCH de la Rosette Herbert Thijs Erika Wisanto Ruth Achten Jean-Paul Ory Gommert van Koeveringe | 2014 | World Journal of Clinical Urology2014，3，2： | 0 |
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