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| 1 | Therapeutic options for the management of pancreatic cancer显示文摘Since its initial characterization, pancreatic ductal adenocarcinoma has remained one of the most devastating and difficult cancers to treat. Pancreatic cancer is the fourth leading cause of death in the United States, resulting in an estimated 38460 deaths annually. With few screening tools available to detect this disease at an early stage, 94% of patients will die within five years of diagnosis. Despite decades of research that have led to a better understanding of the molecular and cellular signaling pathways in pancreatic cancer cells, few effective therapies have been developed to target these pathways. Other treatment options have included more sophisticated pancreatic cancer surgeries and combination therapies. While outcomes have improved modestly for these patients, more effective treatmentsare desperately needed. One of the greatest challenges in the future of treating this malignancy will be to develop therapies that target the tumor microenvironment and surrounding pancreatic cancer stem cells in addition to pancreatic cancer cells. Recent advances in targeting pancreatic stellate cells and the stroma have encouraged researchers to shift their focus to the role of desmoplasia in pancreatic cancer pathobiology in the hopes of developing newer-generation therapies. By combining novel agents with current cytotoxic chemotherapies and radiation therapy and personalizing them to each patient based on specific biomarkers, the goal of prolonging a patient's life could be achieved. Here we review the most effective therapies that have been used for the treatment of pancreatic cancer and discuss the future potential of therapeutic options. | Maria L Rossi Azeem A Rehman Christopher S Gondi | 2014 | World Journal of Gastroenterology2014，20，32： | 13 |
| 2 | Restoration of tissue factor pathway inhibitor inhibits invasion and tumor growth in vitro and in vivo in a malignant meningioma cell line显示文摘 | Kondraganti S Gondi C S Gujrati M | 2006 | Int J Oncol2006，29，1： | 1 |
| 3 | Restoration of tissue factor pathway inhibitor inhibits invasion and tumor growth in vitro and in vivo in a malignant meningioma cell line显示文摘 | Kondraganti S Gondi CS Gujrati M | 2006 | Int J Oncol2006，29，1： | 1 |
| 4 | Expression of antisense uPA froma bicistronic adenoviral constructinhibits glioma cell invasion, tumorgrowth,and angiogenesis 显示文摘 | Gondi CS Lakka SS Yanamandra N | 2003 | Oncogene2003，22，38： | 1 |
| 5 | Drugs in preclinical and early - stage clinical development for pancreatic cancer 显示文摘 | Asuthkar S Rao JS Gondi CS | 2012 | Expert Opin Investig Drugs2012，21，2： | 1 |
| 6 | RNA interference- media- ted targeting of urokinase plasminogen activator receptor and matrix metalloproteinase-9 gene expression in the lOMM-lee malignantmenin- gioma cell line inhibits tumor growth, tumor cell invasion and anglo- genesis显示文摘 | Tummalapalli P Gondi CS Dinh DH | 2007 | Int J Oncol2007，31，1： | 1 |
| 7 | expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas显示文摘 | Gondi CS Lakka SS Yanamandra N | 2004 | Cancer Res2004，64，12： | 1 |
| 8 | RNAi-mediated abrogation of Cathepsin B and MMP-9 gene expression in a malignant meningioma cell line leads to decreased tumor growth,invasion and angiogenesis显示文摘 | Tummalapalli P Spomar D Gondi CS | 2007 | Int J Oncol2007，31，5： | 1 |
| 9 | Suppression of u PA and u PAR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines显示文摘 | Raghu H Lakka SS Gondi CS | 2010 | Plo S one2010，5，12： | 1 |
| 10 | RNAi-mediated inhibition of cathepsin B and uPAR leads to decreased cell invasion,angiogenesis and tumor growth in gliomas显示文摘 | Gondi C S Lakka S S Dinh D H | 2004 | Oncogene2004，23，52： | 1 |
| 11 | Adenovirus-mediated transfer of siRNA against MMP-2 mRNA results in impaired invasion and tumor-induced angiogenesis, induces apoptosis in vitro and inhibits tumor growth in vivo in glioblastoma 显示文摘 | Kargiotis O Chetty C Gondi CS | 2008 | Oncogene2008，27，35： | 1 |
| 12 | siRNA-mediated simultaneous downregulation of uPA and its receptor inhibits angiogenesis and invasiveness triggering apoptosis in breast cancer cells显示文摘 | Subramanian R Gondi CS Lakka SS | 2006 | Int J Oncol2006，28，4： | 1 |
| 13 | Temperature-Regulated Activity of Responsive PolymerProtein Conjugates Prepared by Grafting-from via RAFT Polymerization显示文摘 | De P Li M Gondi S R | 2008 | JAmChemSoc2008，130，11： | 1 |
| 14 | RNAi mediated downregulation of urokinase plasminogen activator receptor and matrix metalloprotease 9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth显示文摘 | Kunigal S Lakka SS Gondi CS | 2007 | Int J Cancer2007，121，10： | 1 |
| 15 | Hippacampal sparing whole-brain radiotherapy:a ' how-to' technique using helicaltomotherapy and lineat-accelierator-based intensity-modulated radiotherapy显示文摘 | Gondi V Tolakanahalli R Mehta MP | | 0，，04： | 1 |
| 16 | Effect of hydroxyapatite on the physicochemical characteristics of a gentamicin-loaded monoolein gel intended to treat chronic osteomyelitis显示文摘 | SemdéR Gondi RF SombiéBC | 2012 | J Adv Pharm Tech Res2012，3，2： | 1 |
| 17 | Versatile pathway to functional telechelics via RAFT polymerization and click chemistry显示文摘 | Gondi S R Vogt A P Sumerlin B S | 2007 | Macromolecules2007，40，3： | 1 |
| 18 | Impact of hybrid fluorodeoxyglucose positron-emission tomography/computed tomography on radiotherapy planning in esophageal can non-small cell lung cancer显示文摘 | Gondi V Bradley K Mineta M | 2007 | Int J Radiat Oncol Biol Phys2007，67，1： | 1 |
| 19 | Hippocampal dosimetry predicts neuroeognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors显示文摘 | Gondi V Hermann BP Mehta MP | 2013 | Int J Radiat Oncol Biol Phys2013，85，2： | 1 |
| 20 | RNAimediated downregulation of urokinase plasminogen activator and its receptor in human meningioma cells inhibits tumor invasion and growth显示文摘 | Kondraganti S Gondi CS Mc Cutcheon I | 2006 | Int J Oncol2006，28，6： | 1 |
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