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| 1 | Comparisons between glucose analogue 2-deoxy-2-(^(18)F)fluoro-D-glucose and ^(18)F-sodium fluoride positron emission tomography/computed tomography in breast cancer patients with bone lesions显示文摘AIM: To compare 2-deoxy-2-(^(18)F)fluoro-D-glucose(^(18)FFDG) and ^(18)F-sodium(^(18)F-NaF) positron emission tomography/computed tomography(PET/CT) accuracy in breast cancer patients with clinically/radiologically suspected or known bone metastases.METHODS: A total of 45 consecutive patients with breast cancer and the presence or clinical/biochemical or radiological suspicion of bone metastatic disease underwent ^(18)F-FDG and ^(18)F-fluoride PET/CT. Imaging results were compared with histopathology when available, or clinical and radiological follow-up of at least 1 year. For each technique we calculated: Sensitivity(Se), specificity(Sp), overall accuracy, positive and negative predictive values, error rate, and Youden's index. Mc Nemar's χ~2 test was used to test the difference in sensitivity and specificity between the two diagnostic methods. All analyses were computed on a patient basis, and then on a lesion basis, with consideration ofthe density of independent lesions on the coregistered CT(sclerotic, lytic, mixed, no-lesions) and the divergent site of disease(skull, spine, ribs, extremities, pelvis). The impact of adding ^(18)F-Na F PET/CT to the work-up of patients was also measured in terms of change in their management due to ^(18)F-Na F PET/CT findings. RESULTS: The two imaging methods of ^(18)F-FDG and ^(18)F-fluoride PET/CT were significantly different at the patient-based analysis: Accuracy was 86.7% and 84.4%, respectively(Mc Nemar's χ~2 = 6.23, df = 1, P = 0.01). Overall, 244 bone lesions were detected in our analysis. The overall accuracy of the two methods was significantly different at lesion-based analysis(Mc Nemar's χ~2 = 93.4, df = 1, P < 0.0001). In the lesion density-based and site-based analysis, ^(18)F-FDG PET/CT provided more accurate results in the detection of CT-negative metastasis(P < 0.002) and vertebral localizations(P < 0.002); ^(18)F-Na F PET/CT was more accurate in detecting sclerotic(P < 0.005) and rib lesions(P < 0.04). ^(18)F-Na F PET/CT led to a change of management in 3 of the 45 patients(6.6%) by revealing findings that were not detected at ^(18)F-FDG PET/CT. CONCLUSION: ^(18)F-FDG PET/CT is a reliable imaging tool in the detection of bone metastasis in most cases, with a diagnostic accuracy that is slightly, but significantly, superior to that of ^(18)F-Na F PET/CT in the general population of breast cancer patients. However, the extremely high sensitivity of ^(18)F-fluoride PET/CT can exploit its diagnostic potential in specific clinical settings(i.e., small CT-evident sclerotic lesions, high clinical suspicious of relapse, and negative ^(18)F-FDG PET and conventional imaging). | Selene Capitanio Francesca Bongioanni Arnoldo Piccardo Claudio Campus Roberta Gonella Lucia Tixi Mehrdad Naseri Michele Pennone Vania Altrinetti Ambra Buschiazzo Irene Bossert Francesco Fiz Andrea Bruno Andrea DeCensi Gianmario Sambuceti Silvia Morbelli | 2016 | World Journal of Radiology2016，8，2： | 3 |
| 2 | Dose-dense vinorelbine and paclitaxel with granulocyte colony-stimulating factor in metastatic breast patients:anti-tumor activity and peripheral blood progenitor cell mobilization capability显示文摘 | Ballestrero A Montemurro F Gonella R | 2003 | Breast Cancer Res Treat2003，82，3： | 1 |
| 3 | Analysis of in-plane wave propagation in hexagonal and re-entrant lat-tices显示文摘 | Gonella S Ruzzene M | 2008 | Journal of Sound and Vibration2008，312，12： | 1 |
| 4 | Phononic properties of hexagonal chiral lattices显示文摘 | Spadoni A Ruzzene M Gonella S Scarpa F | 2009 | Wave Motion2009，46，7： | 1 |
| 5 | Phononicproperties of hexagonal chiral lattices显示文摘 | Spadoni A Ruzzene M Gonella S and Scarpa F | 2009 | Wave Motion2009，46，7： | 1 |
| 6 | Modelling the ion exchange process in glass : Phenomenological approaches and perspectives 显示文摘 | Quaranta A Cattaruzza E Gonella F | 2008 | Materials Science & Engineering B2008，149，： | 1 |
| 7 | Laser-induced sign reversal of the nonlinear refractive index of Ag nanoclusters in soda-limeglass显示文摘 | OSBORNE D H HAGLUND R F GONELLA F | 1998 | Appl Phys B Lasers Opt1998，66，4： | 1 |
| 8 | Short and long-term outcomes of percutaneous revascularization in patients with prior coronary artery bypass graft显示文摘 | D'Ascenzo F Gonella A Longo G | | 0，，03： | 1 |
| 9 | Detection and size determination of Ag nanoclusters in ion - exchanged soda - lime glasses by waveguided raman spectroscopy 显示文摘 | Ferrari M Gonella F Montagna M | 1996 | J Appl Phys1996，79，4： | 1 |
| 10 | Au-Cu Alloy Nanoclusters in Silica Formed by Ion Implantation and Annealing in Reducing or Oxidizing Atmosphere 显示文摘 | Mattei G Mazzoldi P | 1999 | Appl Phys Lett1999，75，1： | 1 |
| 11 | Diffusion behavior of transition metals in field - assisted ion - exchange glasses 显示文摘 | Gonella F Cattaruzza E Quaranta A | 2006 | Solid State Ionies2006，，177： | 1 |
| 12 | A new power sensitivity method of ranking branch outage contingencies for voltage collapse显示文摘 | Gonella R Dondeti J R | 2002 | IEEE Trans on Power Systems2002，17，2： | 1 |
| 13 | Improved bone morphology by normalizing serum magnesium in chronically hemodialyzed patients显示文摘 | Gonella M Ballanti P Della-Roca C | 1988 | Miner Electro- lyte Metab1988，14，4： | 1 |
| 14 | Homogenization of vibratingperiodic lattice structures显示文摘 | Gonella S Ruzzene M | 2008 | Applied MathematicalModelling2008，32，4： | 1 |
| 15 | Extrinsic control of digestive tract motility 显示文摘 | Roman C Gonella J | 1981 | Physiology of the Gastrointestinal Tract1981，9，： | 1 |
| 16 | Charaterization of Cu-Na ion-exchanged glass waveguides 显示文摘 | Gonella F | 1996 | Appl Phys Lett1996，69，3： | 1 |
| 17 | Copper diffusion in ion-exchanged soda-lime glass 显示文摘 | GONELLA F QUARANTA A PADOVANI S | 2005 | Appl Phys2005，81，5： | 1 |
| 18 | Copper-doped ion-exchanged waveguide characterization显示文摘 | Gonella F Caccavale F Quaranta A | 1998 | Journal of Modern Optics1998，45，4： | 1 |
| 19 | Analysis of in-plane wave propagation in hexagonal and re-entrant lat- tices显示文摘 | Gonella S Ruzzene M | 2008 | Journal of Sound and Vibration2008，312，12： | 1 |
| 20 | Comparison of mortality rates in women versus men presenting with ST-seg- ment elevation myocardial infarction 显示文摘 | D'Ascenzo F Gonella A Quadri G | 2011 | Am J Cardiol2011，107，5： | 1 |
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